Chemical Evolution of Rhinovirus Identifies Capsid-Destabilizing Mutations Driving Low-pH-Independent Genome Uncoating.

Antiviral Agents / pharmacology Capsid / chemistry Capsid Proteins / genetics Drug Resistance, Viral / drug effects Endosomes / chemistry HeLa Cells Humans Hydrogen-Ion Concentration Intercellular Adhesion Molecule-1 / metabolism Mutation / drug effects Protein Conformation Rhinovirus / chemistry Virion / chemistry Virus Internalization / drug effects Virus Uncoating / drug effects
VP3 ammonium chloride bafilomycin A1 capsid stability host-targeting drugs low-pH endosome neutral pH niclosamide picornavirus reverse genetics viral protein VP1 virus entry and uncoating

Journal

Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724

Informations de publication

Date de publication:
26 01 2022
Historique:
pubmed: 28 10 2021
medline: 19 2 2022
entrez: 27 10 2021
Statut: ppublish

Résumé

Rhinoviruses (RVs) cause recurrent infections of the nasal and pulmonary tracts, life-threatening conditions in chronic respiratory illness patients, predisposition of children to asthmatic exacerbation, and large economic cost. RVs are difficult to treat. They rapidly evolve resistance and are genetically diverse. Here, we provide insight into RV drug resistance mechanisms against chemical compounds neutralizing low pH in endolysosomes. Serial passaging of RV-A16 in the presence of the vacuolar proton ATPase inhibitor bafilomycin A1 (BafA1) or the endolysosomotropic agent ammonium chloride (NH

Identifiants

DOI: 10.1128/JVI.01060-21 PMID: 34705560 PMC: PMC8791267
pubmed: 34705560
doi: 10.1128/JVI.01060-21
pmc: PMC8791267
doi:

Substances chimiques

Antiviral Agents 0
Capsid Proteins 0
ICAM1 protein, human 0
Intercellular Adhesion Molecule-1 126547-89-5

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e0106021

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Auteurs

Luca Murer (L)

Department of Molecular Life Sciences, University of Zurichgrid.7400.3, Zurich, Switzerland.
ORCID: 0000-0002-2137-4576

Anthony Petkidis (A)

Department of Molecular Life Sciences, University of Zurichgrid.7400.3, Zurich, Switzerland.

Thomas Vallet (T)

Institut Pasteurgrid.428999.7, Viral Populations and Pathogenesis Unit, Department of Virology, CNRS UMR 3569, Paris, France.

Marco Vignuzzi (M)

Institut Pasteurgrid.428999.7, Viral Populations and Pathogenesis Unit, Department of Virology, CNRS UMR 3569, Paris, France.
ORCID: 0000-0002-4400-771X

Urs F Greber (UF)

Department of Molecular Life Sciences, University of Zurichgrid.7400.3, Zurich, Switzerland.
ORCID: 0000-0003-2278-120X

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiviraux › Chemical Evolution of Rhinovirus Identifies...
questionsmedicales.fr › Structures virales › Virion › Nucléocapside › Capside › Chemical Evolution of Rhinovirus Identifies...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines virales › Protéines virales structurales › Protéines nucléocapside › Protéines de capside › Chemical Evolution of Rhinovirus Identifies...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Résistance microbienne aux médicaments › Résistance virale aux médicaments › Chemical Evolution of Rhinovirus Identifies...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Vésicules cytoplasmiques › Vésicules de transport › Endosomes › Chemical Evolution of Rhinovirus Identifies...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HeLa › Chemical Evolution of Rhinovirus Identifies...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Chemical Evolution of Rhinovirus Identifies...
questionsmedicales.fr › Phénomènes chimiques › Concentration en ions d'hydrogène › Chemical Evolution of Rhinovirus Identifies...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Antigènes de surface › Molécules d'adhérence cellulaire › Molécule-1 d'adhérence intercellulaire › Chemical Evolution of Rhinovirus Identifies...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Chemical Evolution of Rhinovirus Identifies...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Chemical Evolution of Rhinovirus Identifies...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Picornaviridae › Rhinovirus › Chemical Evolution of Rhinovirus Identifies...
questionsmedicales.fr › Structures virales › Virion › Chemical Evolution of Rhinovirus Identifies...
questionsmedicales.fr › Phénomènes microbiologiques › Phénomènes physiologiques viraux › Pénétration virale › Chemical Evolution of Rhinovirus Identifies...
questionsmedicales.fr › Phénomènes microbiologiques › Phénomènes physiologiques viraux › Décapsidation virale › Chemical Evolution of Rhinovirus Identifies...