X-treme loss of sequence diversity linked to neo-X chromosomes in filarial nematodes.
Journal
PLoS neglected tropical diseases
ISSN: 1935-2735
Titre abrégé: PLoS Negl Trop Dis
Pays: United States
ID NLM: 101291488
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
received:
18
12
2020
accepted:
24
09
2021
revised:
08
11
2021
pubmed:
28
10
2021
medline:
17
12
2021
entrez:
27
10
2021
Statut:
epublish
Résumé
The sequence diversity of natural and laboratory populations of Brugia pahangi and Brugia malayi was assessed with Illumina resequencing followed by mapping in order to identify single nucleotide variants and insertions/deletions. In natural and laboratory Brugia populations, there is a lack of sequence diversity on chromosome X relative to the autosomes (πX/πA = 0.2), which is lower than the expected (πX/πA = 0.75). A reduction in diversity is also observed in other filarial nematodes with neo-X chromosome fusions in the genera Onchocerca and Wuchereria, but not those without neo-X chromosome fusions in the genera Loa and Dirofilaria. In the species with neo-X chromosome fusions, chromosome X is abnormally large, containing a third of the genetic material such that a sizable portion of the genome is lacking sequence diversity. Such profound differences in genetic diversity can be consequential, having been associated with drug resistance and adaptability, with the potential to affect filarial eradication.
Identifiants
pubmed: 34705823
doi: 10.1371/journal.pntd.0009838
pii: PNTD-D-20-02198
pmc: PMC8575316
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0009838Subventions
Organisme : NIAID NIH HHS
ID : U19 AI110820
Pays : United States
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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