Interleukin-10 induces interferon-γ-dependent emergency myelopoiesis.

Animals CD4-Positive T-Lymphocytes / immunology CD8-Positive T-Lymphocytes / immunology Interferon-gamma / genetics Interleukin-10 / genetics Mice Mice, Knockout Myeloid Progenitor Cells / immunology Myelopoiesis / genetics
IFN-γ IL-10 T cells emergency myelopoiesis

Journal

Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691

Informations de publication

Date de publication:
26 10 2021
Historique:
received: 18 11 2020
revised: 17 05 2021
accepted: 05 10 2021
entrez: 27 10 2021
pubmed: 28 10 2021
medline: 11 2 2022
Statut: ppublish

Résumé

In emergency myelopoiesis (EM), expansion of the myeloid progenitor compartment and increased myeloid cell production are observed and often mediated by the pro-inflammatory cytokine interferon gamma (IFN-γ). Interleukin-10 (IL-10) inhibits IFN-γ secretion, but paradoxically, its therapeutic administration to humans causes hematologic changes similar to those observed in EM. In this work, we use different in vivo systems, including a humanized immune system mouse model, to show that IL-10 triggers EM, with a significant expansion of the myeloid progenitor compartment and production of myeloid cells. Hematopoietic progenitors display a prominent IFN-γ transcriptional signature, and we show that IFN-γ mediates IL-10-driven EM. We also find that IL-10, unexpectedly, reprograms CD4 and CD8 T cells toward an activation state that includes IFN-γ production by these T cell subsets in vivo. Therefore, in addition to its established anti-inflammatory properties, IL-10 can induce IFN-γ production and EM, opening additional perspectives for the design of IL-10-based immunotherapies.

Identifiants

DOI: 10.1016/j.celrep.2021.109887 PMID: 34706233
pubmed: 34706233
pii: S2211-1247(21)01357-7
doi: 10.1016/j.celrep.2021.109887
pii:
doi:

Substances chimiques

IFNG protein, mouse 0
IL10 protein, mouse 0
Interleukin-10 130068-27-8
Interferon-gamma 82115-62-6

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

109887

Informations de copyright

Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests Y.L. is currently consulting for GemPharmatech Co.

Auteurs

Ana Cardoso (A)

i3S-Instituto de Investigação e Inovação em Saúde, Porto, Portugal; IBMC-Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal; Department of Immunology, Institut Pasteur, Université de Paris, Unité Lymphocytes et Immunité, 75015 Paris, France. Electronic address: ana.cardoso@crick.ac.uk.

Ana Catarina Martins (AC)

i3S-Instituto de Investigação e Inovação em Saúde, Porto, Portugal; IBMC-Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal; Doctoral Program in Molecular and Cell Biology, Instituto de Ciências Biomédicas Abel Salazar (ICBAS), University of Porto, Porto, Portugal.

Ana Raquel Maceiras (AR)

i3S-Instituto de Investigação e Inovação em Saúde, Porto, Portugal; IBMC-Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal.

Wei Liu (W)

MOE Key Laboratory of Model Animals for Disease Study, Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, Chemistry and Biomedicine Innovation Center (ChemBIC), Model Animal Research Center, Nanjing University Medical School, Nanjing University, Nanjing, China.

Isabel Castro (I)

ICVS, University of Minho, Braga, Portugal; ICVS/3B-PT Government Associate Laboratory, Braga/Guimarães, Portugal.

António G Castro (AG)

ICVS, University of Minho, Braga, Portugal; ICVS/3B-PT Government Associate Laboratory, Braga/Guimarães, Portugal.

António Bandeira (A)

Department of Immunology, Institut Pasteur, Université de Paris, Unité Lymphocytes et Immunité, 75015 Paris, France; INSERM U1223, 75015 Paris, France; University Paris Diderot, Sorbonne Paris Cité, Cellule Pasteur, 75015 Paris, France.

James P Di Santo (JP)

INSERM U1223, 75015 Paris, France; Department of Immunology, Institut Pasteur, Université de Paris, Unité Immunité Innée, 75015 Paris, France.

Ana Cumano (A)

Department of Immunology, Institut Pasteur, Université de Paris, Unité Lymphocytes et Immunité, 75015 Paris, France; INSERM U1223, 75015 Paris, France; University Paris Diderot, Sorbonne Paris Cité, Cellule Pasteur, 75015 Paris, France.

Yan Li (Y)

MOE Key Laboratory of Model Animals for Disease Study, Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, Chemistry and Biomedicine Innovation Center (ChemBIC), Model Animal Research Center, Nanjing University Medical School, Nanjing University, Nanjing, China; Department of Immunology, Institut Pasteur, Université de Paris, Unité Immunité Innée, 75015 Paris, France.

Paulo Vieira (P)

Department of Immunology, Institut Pasteur, Université de Paris, Unité Lymphocytes et Immunité, 75015 Paris, France; INSERM U1223, 75015 Paris, France; University Paris Diderot, Sorbonne Paris Cité, Cellule Pasteur, 75015 Paris, France. Electronic address: paulo.vieira@pasteur.fr.

Margarida Saraiva (M)

i3S-Instituto de Investigação e Inovação em Saúde, Porto, Portugal; IBMC-Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal. Electronic address: margarida.saraiva@ibmc.up.pt.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Interleukin-10 induces interferon-γ-dependent...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD4+ › Interleukin-10 induces interferon-γ-dependent...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD8+ › Interleukin-10 induces interferon-γ-dependent...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Lymphokines › Facteurs d'activation des macrophages › Interféron gamma › Interleukin-10 induces interferon-γ-dependent...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Interleukine-10 › Interleukin-10 induces interferon-γ-dependent...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Interleukin-10 induces interferon-γ-dependent...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Interleukin-10 induces interferon-γ-dependent...
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questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiogiques du sang › Hématopoïèse › Leucopoïèse › Myélopoïèse › Interleukin-10 induces interferon-γ-dependent...