Cyclosporine A but Not Corticosteroids Support Efficacy of
Adoptive Transfer
Adrenal Cortex Hormones
/ pharmacology
Animals
Biopsy
Cyclosporine
/ pharmacology
Disease Management
Disease Models, Animal
Disease Susceptibility
Graft vs Host Disease
/ diagnosis
Heterografts
Immunosuppressive Agents
/ pharmacology
Mice
Mice, Inbred NOD
Mice, SCID
T-Lymphocytes, Regulatory
/ drug effects
Treatment Outcome
Graft-versus-Host Disease
adoptive cell therapy
drug interaction
immunosuppressive drugs
regulatory T-cells
tolerance
transplantation
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
28
05
2021
accepted:
02
09
2021
entrez:
28
10
2021
pubmed:
29
10
2021
medline:
21
12
2021
Statut:
epublish
Résumé
Reshaping the immune balance by adoptive transfer of regulatory T-cells (Tregs) has emerged as a promising strategy to combat undesired immune reactions, including in Graft-versus-Host Disease (GvHD), which is the most lethal non-relapse complication of allogeneic hematopoietic stem cell transplantation. Currently however, little is known about the potentially inhibitory
Identifiants
pubmed: 34707604
doi: 10.3389/fimmu.2021.716629
pmc: PMC8543016
doi:
Substances chimiques
Adrenal Cortex Hormones
0
Immunosuppressive Agents
0
Cyclosporine
83HN0GTJ6D
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
716629Informations de copyright
Copyright © 2021 Landwehr-Kenzel, Zobel, Schmitt-Knosalla, Forke, Hoffmann, Schmueck-Henneresse, Klopfleisch, Volk and Reinke.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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