Monocytes in central nervous system remyelination.
macrophages
monocyte subsets
monocyte-derived macrophages
monocytes
multiple sclerosis
remyelination
Journal
Glia
ISSN: 1098-1136
Titre abrégé: Glia
Pays: United States
ID NLM: 8806785
Informations de publication
Date de publication:
05 2022
05 2022
Historique:
revised:
19
10
2021
received:
26
08
2021
accepted:
20
10
2021
pubmed:
29
10
2021
medline:
20
4
2022
entrez:
28
10
2021
Statut:
ppublish
Résumé
Remyelination failure with aging and progression of neurodegenerative disorders contributes to axonal dysfunction, highlighting the importance of understanding the mechanisms underpinning this process to develop regenerative therapies. Central nervous system (CNS) macrophages, encompassing both resident microglia and blood monocyte-derived cells, play a crucial role in driving successful remyelination. Although there has been a focus on the critical roles of microglia in remyelination, the specific contribution of monocyte-derived macrophages is still not fully understood. Until recently, the lack of tools enabling distinction between CNS macrophage populations has hindered our understanding of monocyte influence on remyelination. Recent advances have allowed for identification and characterization of monocyte populations in health, aging and in neurodegenerative conditions like multiple sclerosis, indicating heterogeneity of monocyte subsets impacted by both intrinsic and extrinsic factors. Here, we discuss the new tools enabling distinction between macrophage populations and advancements in understanding the importance of monocytes in remyelination, and reflect on the potential for therapeutic targeting of monocytes to promote remyelination.
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
797-807Subventions
Organisme : Medical Research Council
ID : MR/V031260/1
Pays : United Kingdom
Informations de copyright
© 2021 The Authors. GLIA published by Wiley Periodicals LLC.
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