Long-term antagonism and allosteric regulation of mu opioid receptors by the novel ligand, methocinnamox.
Allosteric Regulation
/ drug effects
Animals
Cinnamates
/ pharmacology
Cyclic AMP
/ metabolism
Enkephalin, Ala(2)-MePhe(4)-Gly(5)-
/ pharmacology
HEK293 Cells
Humans
Ligands
Male
Morphine Derivatives
/ pharmacology
Naloxone
/ pharmacology
Narcotic Antagonists
/ pharmacology
Rats
Rats, Sprague-Dawley
Receptors, Opioid, mu
/ antagonists & inhibitors
Time Factors
GPCR
allosteric regulation
opioid
unsurmountable antagonism
Journal
Pharmacology research & perspectives
ISSN: 2052-1707
Titre abrégé: Pharmacol Res Perspect
Pays: United States
ID NLM: 101626369
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
received:
30
03
2021
accepted:
30
09
2021
entrez:
29
10
2021
pubmed:
30
10
2021
medline:
16
2
2022
Statut:
ppublish
Résumé
Opioid overdose is a leading cause of death in the United States. The only treatment available currently is the competitive antagonist, naloxone (Narcan
Identifiants
pubmed: 34713624
doi: 10.1002/prp2.887
pmc: PMC8554411
doi:
Substances chimiques
Cinnamates
0
Ligands
0
Morphine Derivatives
0
Narcotic Antagonists
0
Receptors, Opioid, mu
0
methocinnamox
0
Enkephalin, Ala(2)-MePhe(4)-Gly(5)-
100929-53-1
Naloxone
36B82AMQ7N
Cyclic AMP
E0399OZS9N
Types de publication
Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e00887Subventions
Organisme : NIDA NIH HHS
ID : R01 DA038645
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA048214
Pays : United States
Informations de copyright
© 2021 The Authors. Pharmacology Research & Perspectives published by British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics and John Wiley & Sons Ltd.
Références
JAMA Intern Med. 2019 Jun 1;179(6):805-811
pubmed: 31058922
J Pharmacol Exp Ther. 2017 Jul;362(1):200-209
pubmed: 28465374
J Pharmacol Exp Ther. 2015 Apr;353(1):44-51
pubmed: 25637601
J Pharmacol Exp Ther. 2019 Nov;371(2):507-516
pubmed: 31439807
Mol Pharmacol. 2012 Jan;81(1):41-52
pubmed: 21989256
MMWR Morb Mortal Wkly Rep. 2020 Mar 20;69(11):290-297
pubmed: 32191688
Neuropsychopharmacology. 2020 Nov;45(12):1986-1993
pubmed: 32375158
J Pharmacol Exp Ther. 1986 Nov;239(2):351-7
pubmed: 3021954
MMWR Morb Mortal Wkly Rep. 2015 Jun 19;64(23):631-5
pubmed: 26086633
Br J Pharmacol. 2021 May 24;:
pubmed: 34030211
BMJ. 2013 Jan 30;346:f174
pubmed: 23372174
J Med Chem. 2006 Oct 5;49(20):6104-10
pubmed: 17004724
J Pharmacol Exp Ther. 1996 Oct;279(1):23-31
pubmed: 8858971
Drug Alcohol Depend. 2020 Apr 1;209:107890
pubmed: 32058246
J Mol Model. 2019 May 3;25(5):144
pubmed: 31053968
Mol Pharmacol. 1987 Sep;32(3):321-9
pubmed: 2823089
J Med Chem. 2000 Feb 10;43(3):381-91
pubmed: 10669565
MMWR Morb Mortal Wkly Rep. 2019 May 03;68(17):388-395
pubmed: 31048676
Mol Pharmacol. 2012 Feb;81(2):264-72
pubmed: 22072818
J Pharmacol Exp Ther. 2011 Jul;338(1):92-9
pubmed: 21487072
Nucleic Acids Res. 2018 Jan 4;46(D1):D1091-D1106
pubmed: 29149325
Ther Adv Drug Saf. 2018 Jan;9(1):63-88
pubmed: 29318006
Pain. 1988 Jan;32(1):77-88
pubmed: 3340425
Anesthesiology. 2010 Jan;112(1):226-38
pubmed: 20010421
Br J Pharmacol. 2021 Oct;178 Suppl 1:S27-S156
pubmed: 34529832
Drug Alcohol Depend. 2021 Jan 1;218:108384
pubmed: 33158665
Mol Pharmacol. 2018 Apr;93(4):376-386
pubmed: 29436492
J Pharmacol Exp Ther. 2007 Jun;321(3):839-47
pubmed: 17347322
JAMA Psychiatry. 2019 Feb 1;76(2):208-216
pubmed: 30516809
J Pharmacol Exp Ther. 2016 Dec;359(3):411-419
pubmed: 27660244
Curr Opin Pharmacol. 2009 Feb;9(1):3-8
pubmed: 19157985
Curr Protoc Pharmacol. 2008 Jun;Chapter 1:Unit1.2
pubmed: 22294216
Pharmacol Rev. 2010 Dec;62(4):701-25
pubmed: 21079041
Eur J Pharmacol. 2009 Jan 14;602(2-3):283-7
pubmed: 19063879
J Pharmacol Exp Ther. 2000 Sep;294(3):933-40
pubmed: 10945843
Nucleic Acids Res. 2020 Jan 8;48(D1):D1006-D1021
pubmed: 31691834
J Med Chem. 1980 Mar;23(3):233-4
pubmed: 6245210
J Pharmacol Exp Ther. 2019 Jan;368(1):88-99
pubmed: 30401680
Pharmacol Rev. 2002 Jun;54(2):323-74
pubmed: 12037145
Addiction. 2020 May;115(5):946-958
pubmed: 31912625