Derivation and Validation of Genome-Wide Polygenic Score for Ischemic Heart Failure.
genomics
heart failure
personalized medicine
polygenic risk score
Journal
Journal of the American Heart Association
ISSN: 2047-9980
Titre abrégé: J Am Heart Assoc
Pays: England
ID NLM: 101580524
Informations de publication
Date de publication:
16 11 2021
16 11 2021
Historique:
pubmed:
30
10
2021
medline:
4
3
2022
entrez:
29
10
2021
Statut:
ppublish
Résumé
Background Despite advances in cardiovascular disease and risk factor management, mortality from ischemic heart failure (HF) in patients with coronary artery disease (CAD) remains high. Given the partial role of genetics in HF and lack of reliable risk stratification tools, we developed and validated a polygenic risk score for HF in patients with CAD, which we term HF-PRS. Methods and Results Using summary statistics from a recent genome-wide association study for HF, we developed candidate PRSs in the Mount Sinai Bio
Identifiants
pubmed: 34713709
doi: 10.1161/JAHA.121.021916
pmc: PMC8751935
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e021916Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK108803
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL139865
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG007278
Pays : United States
Organisme : NIDDK NIH HHS
ID : K23 DK107908
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM124836
Pays : United States
Organisme : CSRD VA
ID : IK2 CX001780
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG009610
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK116100
Pays : United States
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