The Many Roles of Cholesterol in Sepsis: A Review.
cholesterol
hypocholesterolemia
lipid metabolism
sepsis
Journal
American journal of respiratory and critical care medicine
ISSN: 1535-4970
Titre abrégé: Am J Respir Crit Care Med
Pays: United States
ID NLM: 9421642
Informations de publication
Date de publication:
15 02 2022
15 02 2022
Historique:
pubmed:
30
10
2021
medline:
4
3
2022
entrez:
29
10
2021
Statut:
ppublish
Résumé
The biological functions of cholesterol are diverse, ranging from cell membrane integrity, cell membrane signaling, and immunity to the synthesis of steroid and sex hormones, vitamin D, bile acids, and oxysterols. Multiple studies have demonstrated hypocholesterolemia in sepsis, the degree of which is an excellent prognosticator of poor outcomes. However, the clinical significance of hypocholesterolemia has been largely unrecognized. We undertook a detailed review of the biological roles of cholesterol, the impact of sepsis, its reliability as a prognosticator in sepsis, and the potential utility of cholesterol as a treatment. Sepsis affects cholesterol synthesis, transport, and metabolism. This likely impacts its biological functions, including immunity, hormone and vitamin production, and cell membrane receptor sensitivity. Early preclinical studies show promise for cholesterol as a pleiotropic therapeutic agent. Hypocholesterolemia is a frequent condition in sepsis and an important early prognosticator. Low plasma concentrations are associated with wider changes in cholesterol metabolism and its functional roles, and these appear to play a significant role in sepsis pathophysiology. The therapeutic impact of cholesterol elevation warrants further investigation.
Identifiants
pubmed: 34715007
doi: 10.1164/rccm.202105-1197TR
pmc: PMC8886946
doi:
Substances chimiques
Cholesterol
97C5T2UQ7J
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
388-396Subventions
Organisme : Medical Research Council
ID : MC_PC_17180
Pays : United Kingdom
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