Genomic convergence between Akkermansia muciniphila in different mammalian hosts.
Beneficial microbe
Comparative genomics
Gastrointestinal-tract
Gut bacteria
Phylogenetic analysis
Journal
BMC microbiology
ISSN: 1471-2180
Titre abrégé: BMC Microbiol
Pays: England
ID NLM: 100966981
Informations de publication
Date de publication:
29 10 2021
29 10 2021
Historique:
received:
06
04
2021
accepted:
12
10
2021
entrez:
30
10
2021
pubmed:
31
10
2021
medline:
14
1
2022
Statut:
epublish
Résumé
Akkermansia muciniphila is a member of the human gut microbiota where it resides in the mucus layer and uses mucin as the sole carbon, nitrogen and energy source. A. muciniphila is the only representative of the Verrucomicrobia phylum in the human gut. However, A. muciniphila 16S rRNA gene sequences have also been found in the intestines of many vertebrates. We detected A. muciniphila-like bacteria in the intestines of animals belonging to 15 out of 16 mammalian orders. In addition, other species belonging to the Verrucomicrobia phylum were detected in fecal samples. We isolated 10 new A. muciniphila strains from the feces of chimpanzee, siamang, mouse, pig, reindeer, horse and elephant. The physiology and genome of these strains were highly similar in comparison to the type strain A. muciniphila Muc The low genomic divergence observed in the new strains may indicate that A. muciniphila favors mucosal colonization independent of the differences in hosts. In addition, the conserved mucus degradation capability points towards a similar beneficial role of the new strains in regulating host metabolic health.
Sections du résumé
BACKGROUND
Akkermansia muciniphila is a member of the human gut microbiota where it resides in the mucus layer and uses mucin as the sole carbon, nitrogen and energy source. A. muciniphila is the only representative of the Verrucomicrobia phylum in the human gut. However, A. muciniphila 16S rRNA gene sequences have also been found in the intestines of many vertebrates.
RESULTS
We detected A. muciniphila-like bacteria in the intestines of animals belonging to 15 out of 16 mammalian orders. In addition, other species belonging to the Verrucomicrobia phylum were detected in fecal samples. We isolated 10 new A. muciniphila strains from the feces of chimpanzee, siamang, mouse, pig, reindeer, horse and elephant. The physiology and genome of these strains were highly similar in comparison to the type strain A. muciniphila Muc
CONCLUSIONS
The low genomic divergence observed in the new strains may indicate that A. muciniphila favors mucosal colonization independent of the differences in hosts. In addition, the conserved mucus degradation capability points towards a similar beneficial role of the new strains in regulating host metabolic health.
Identifiants
pubmed: 34715771
doi: 10.1186/s12866-021-02360-6
pii: 10.1186/s12866-021-02360-6
pmc: PMC8555344
doi:
Substances chimiques
Mucins
0
RNA, Ribosomal, 16S
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
298Informations de copyright
© 2021. The Author(s).
Références
Bioinformatics. 2018 Jan 15;34(2):292-293
pubmed: 29028899
Science. 2011 May 20;332(6032):970-4
pubmed: 21596990
ISME J. 2011 Jan;5(1):92-106
pubmed: 20613788
Bioinformatics. 2012 Jun 1;28(11):1420-8
pubmed: 22495754
Cell Rep. 2016 Feb 23;14(7):1655-1661
pubmed: 26854221
BMC Bioinformatics. 2010 Mar 08;11:119
pubmed: 20211023
Int J Syst Evol Microbiol. 2004 Sep;54(Pt 5):1469-1476
pubmed: 15388697
Vet Microbiol. 2013 Sep 27;166(1-2):286-92
pubmed: 23810699
Gut. 2011 Oct;60(10):1412-25
pubmed: 21228430
Nat Med. 2017 Jan;23(1):107-113
pubmed: 27892954
Front Microbiol. 2017 Sep 22;8:1765
pubmed: 29018410
Nat Rev Microbiol. 2008 Oct;6(10):776-88
pubmed: 18794915
Nat Med. 2019 Jul;25(7):1096-1103
pubmed: 31263284
Bioinformatics. 2007 May 15;23(10):1282-8
pubmed: 17379688
Science. 2003 Mar 7;299(5612):1582-5
pubmed: 12624269
PLoS Genet. 2013;9(8):e1003683
pubmed: 23966868
Science. 2008 Jun 20;320(5883):1647-51
pubmed: 18497261
Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):2117-22
pubmed: 18252821
Appl Environ Microbiol. 2007 Dec;73(23):7767-70
pubmed: 17933936
Bioinformatics. 2012 Dec 15;28(24):3211-7
pubmed: 23071270
Nucleic Acids Res. 2004 Feb 25;32(4):1363-71
pubmed: 14985472
BMC Bioinformatics. 2007 Jun 18;8:209
pubmed: 17577412
Bioinformatics. 2015 Nov 15;31(22):3691-3
pubmed: 26198102
Appl Environ Microbiol. 2012 Mar;78(5):1544-55
pubmed: 22194293
Gastroenterology. 1981 Oct;81(4):759-65
pubmed: 7262520
Nucleic Acids Res. 1997 Mar 1;25(5):955-64
pubmed: 9023104
Appl Environ Microbiol. 2009 Oct;75(20):6451-6
pubmed: 19700553
J Bacteriol. 1991 Jan;173(2):697-703
pubmed: 1987160
Bioinformatics. 2012 Jul 15;28(14):1823-9
pubmed: 22556368
Infect Immun. 1993 May;61(5):1601-10
pubmed: 8478048
Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):4720-5
pubmed: 23487774
Appl Environ Microbiol. 2017 Aug 31;83(18):
pubmed: 28687644
PLoS Genet. 2011 Mar;7(3):e1001342
pubmed: 21436896
Nucleic Acids Res. 2013 Jan;41(Database issue):D590-6
pubmed: 23193283
Immun Ageing. 2019 Mar 8;16:6
pubmed: 30899315
Appl Environ Microbiol. 2000 Nov;66(11):4605-14
pubmed: 11055900
Mol Ecol. 2014 Mar;23(6):1268-83
pubmed: 24304129
Nature. 2009 Jan 22;457(7228):480-4
pubmed: 19043404
ISME J. 2012 Aug;6(8):1449-58
pubmed: 22437156
Genome Biol. 2012 Dec 22;13(12):R122
pubmed: 23259615
Am J Physiol Regul Integr Comp Physiol. 2013 Jan 1;304(1):R33-42
pubmed: 23152108
ISME J. 2010 Nov;4(11):1375-85
pubmed: 20520652
PLoS One. 2011 Mar 03;6(3):e16876
pubmed: 21390229
ISME J. 2013 Sep;7(9):1803-13
pubmed: 23657364
J Appl Microbiol. 2016 Feb;120(2):452-9
pubmed: 26666632
Inflamm Bowel Dis. 2013 Mar;19(3):481-8
pubmed: 23385241
Int J Syst Evol Microbiol. 2016 Nov;66(11):4614-4620
pubmed: 27499019
Nucleic Acids Res. 2013 Jan;41(Database issue):D226-32
pubmed: 23125362
Nucleic Acids Res. 2003 Nov 15;31(22):6633-9
pubmed: 14602924
FEMS Microbiol Rev. 2011 Jul;35(4):681-704
pubmed: 21361997
BMC Genomics. 2017 Oct 18;18(1):800
pubmed: 29047329
Appl Environ Microbiol. 2002 Jun;68(6):3121-5
pubmed: 12039775
Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3229-36
pubmed: 23391737
Appl Environ Microbiol. 2007 Jan;73(1):278-88
pubmed: 17071787
Bioinformatics. 2014 Jul 15;30(14):2068-9
pubmed: 24642063
Nucleic Acids Res. 2012 Jan;40(Database issue):D306-12
pubmed: 22096229
Nucleic Acids Res. 2007;35(9):3100-8
pubmed: 17452365
Science. 2005 Jun 10;308(5728):1635-8
pubmed: 15831718
Proc Natl Acad Sci U S A. 2013 May 28;110(22):9066-71
pubmed: 23671105