Genome-wide association study identifies susceptibility loci for acute myeloid leukemia.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
29 10 2021
29 10 2021
Historique:
received:
30
01
2020
accepted:
01
10
2021
entrez:
30
10
2021
pubmed:
31
10
2021
medline:
1
12
2021
Statut:
epublish
Résumé
Acute myeloid leukemia (AML) is a hematological malignancy with an undefined heritable risk. Here we perform a meta-analysis of three genome-wide association studies, with replication in a fourth study, incorporating a total of 4018 AML cases and 10488 controls. We identify a genome-wide significant risk locus for AML at 11q13.2 (rs4930561; P = 2.15 × 10
Identifiants
pubmed: 34716350
doi: 10.1038/s41467-021-26551-x
pii: 10.1038/s41467-021-26551-x
pmc: PMC8556284
doi:
Substances chimiques
HLA Antigens
0
AKR1B1 protein, human
EC 1.1.1.21
Aldehyde Reductase
EC 1.1.1.21
Types de publication
Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
6233Subventions
Organisme : Medical Research Council
ID : MR/P002005/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/T004231/1
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : R01 HL102278
Pays : United States
Organisme : NCI NIH HHS
ID : R03 CA188733
Pays : United States
Organisme : Medical Research Council
ID : G0700052
Pays : United Kingdom
Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2021. The Author(s).
Références
Cell. 2017 Nov 30;171(6):1259-1271.e11
pubmed: 29107330
Nat Rev Genet. 2016 May;17(5):284-99
pubmed: 26972587
Blood. 1999 May 1;93(9):3074-80
pubmed: 10216104
Blood Cancer J. 2013 Nov 01;3:e155
pubmed: 24185502
Front Pharmacol. 2012 Jun 06;3:104
pubmed: 22685431
Leukemia. 2008 Feb;22(2):424-6
pubmed: 17690700
Sci Transl Med. 2017 May 10;9(389):
pubmed: 28490672
J Exp Med. 2017 Aug 7;214(8):2453-2470
pubmed: 28733386
Blood. 2012 Mar 1;119(9):2114-21
pubmed: 22186996
Front Immunol. 2019 Dec 20;10:3004
pubmed: 31921218
Nat Rev Cancer. 2010 May;10(5):353-61
pubmed: 20414203
Leukemia. 2016 Oct;30(10):2102-2106
pubmed: 27211264
Nat Genet. 2016 Oct;48(10):1279-83
pubmed: 27548312
J Clin Oncol. 2010 Feb 1;28(4):596-604
pubmed: 20026798
Br J Haematol. 2004 Dec;127(5):479-90
pubmed: 15566351
Int J Epidemiol. 2018 Jun 1;47(3):700-700g
pubmed: 29618056
Cell Metab. 2021 Jan 5;33(1):145-159.e6
pubmed: 33357456
Cell. 2011 Mar 4;144(5):646-74
pubmed: 21376230
Cell. 2017 Nov 30;171(6):1272-1283.e15
pubmed: 29107334
Leukemia. 2019 Mar;33(3):771-775
pubmed: 30291333
Rom J Morphol Embryol. 2006;47(4):331-7
pubmed: 17392978
J Clin Oncol. 2013 Jun 10;31(17):2094-102
pubmed: 23630210
Genes Chromosomes Cancer. 2012 Aug;51(8):756-67
pubmed: 22488577
J Clin Oncol. 2010 Feb 1;28(4):586-95
pubmed: 20038732
Blood. 2001 Sep 1;98(5):1302-11
pubmed: 11520775
Br J Cancer. 1999 Dec;81(7):1228-33
pubmed: 10584886
Nat Methods. 2012 Nov;9(11):1046
pubmed: 23281567
Cancer Res. 2006 Apr 1;66(7):3401-8
pubmed: 16585161
J Clin Oncol. 2015 Feb 10;33(5):403-10
pubmed: 25547501
Nat Commun. 2017 Dec 1;8(1):1892
pubmed: 29196614
Carcinogenesis. 2000 Jan;21(1):43-7
pubmed: 10607732
Oncotarget. 2016 Nov 22;7(47):78095-78109
pubmed: 27801668
PLoS One. 2019 Jul 10;14(7):e0219547
pubmed: 31291378
Leukemia. 2018 Oct;32(10):2282-2285
pubmed: 29632341
Semin Oncol. 2012 Dec;39(6):707-15
pubmed: 23206847
Blood. 2005 Dec 1;106(12):3740-6
pubmed: 16051734
Int J Epidemiol. 2006 Feb;35(1):34-41
pubmed: 16155052
Nat Rev Genet. 2013 Nov;14(11):765-80
pubmed: 24105274
Blood. 2010 Nov 11;116(19):3751-7
pubmed: 20705755
Leukemia. 2017 Mar;31(3):555-564
pubmed: 27686867
N Engl J Med. 2016 Jun 9;374(23):2209-2221
pubmed: 27276561
Cancer Cell. 2016 Nov 14;30(5):779-791
pubmed: 27746145
Blood. 2012 Aug 9;120(6):1282-9
pubmed: 22592607
Haematologica. 2017 Dec;102(12):e499-e501
pubmed: 28935849
Am J Hematol. 2012 Nov;87(11):1010-6
pubmed: 22887079
J Exp Med. 2015 Dec 14;212(13):2223-34
pubmed: 26642852
Mol Cell Biol. 2006 May;26(9):3514-26
pubmed: 16611993
N Engl J Med. 2008 May 1;358(18):1909-18
pubmed: 18450602
PLoS One. 2013 Jun 06;8(6):e64683
pubmed: 23762245
PLoS One. 2014 Jun 24;9(6):e100245
pubmed: 24959826
Nat Commun. 2015 Dec 08;6:10004
pubmed: 26643973
Blood. 2014 Sep 4;124(10):1645-54
pubmed: 25006128
Leukemia. 2018 Feb;32(2):273-284
pubmed: 28701730
Nat Rev Endocrinol. 2017 Nov;13(11):674-686
pubmed: 28885622
Blood. 2010 Jul 22;116(3):354-65
pubmed: 20385793
Br J Cancer. 2009 Mar 10;100(5):822-8
pubmed: 19259097
Cell. 2017 Sep 7;170(6):1079-1095.e20
pubmed: 28823558
HLA. 2017 Aug;90(2):95-101
pubmed: 28585303
Nature. 2007 Jun 7;447(7145):661-78
pubmed: 17554300
Am J Hum Genet. 2007 Aug;81(2):208-27
pubmed: 17668372
J Mol Biol. 2019 Aug 9;431(17):3068-3080
pubmed: 31255706
Blood Adv. 2017 Aug 16;1(19):1505-1516
pubmed: 29296792
Leukemia. 2013 Jan;27(1):255-8
pubmed: 22814293
Transplantation. 2012 Apr 15;93(7):744-9
pubmed: 22314337
Oncotarget. 2014 Feb 28;5(4):916-32
pubmed: 24659740
J Clin Invest. 2019 Feb 1;129(2):774-785
pubmed: 30640174
Nat Genet. 2018 Sep;50(9):1219-1224
pubmed: 30104762
Gesundheitswesen. 2005 Aug;67 Suppl 1:S26-30
pubmed: 16032514
Cancer Res. 2018 Apr 1;78(7):1604-1618
pubmed: 29343522
Blood. 2012 Jul 26;120(4):843-6
pubmed: 22700719
Blood. 2013 Jul 4;122(1):100-8
pubmed: 23704090
N Engl J Med. 2009 May 28;360(22):2289-301
pubmed: 19474426
Clin Cancer Res. 2014 Dec 1;20(23):6034-44
pubmed: 25294906
Blood. 2017 Jul 27;130(4):424-432
pubmed: 28600339
Blood. 2014 Dec 4;124(24):3597-607
pubmed: 25267197
Nat Methods. 2011 Dec 04;9(2):179-81
pubmed: 22138821
Blood. 2012 Mar 8;119(10):e67-75
pubmed: 22234698
Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11592-7
pubmed: 11553769
Blood. 2018 Aug 30;132(9):973-976
pubmed: 29991558
Leukemia. 2015 May;29(5):1143-52
pubmed: 25371177