Hemp and buckwheat are valuable sources of dietary amino acids, beneficially modulating gastrointestinal hormones and promoting satiety in healthy volunteers.
Amino acids
Gut hormones
Hunger
Phytochemicals bioavailability
Plant foods
Plant protein
Journal
European journal of nutrition
ISSN: 1436-6215
Titre abrégé: Eur J Nutr
Pays: Germany
ID NLM: 100888704
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
received:
14
06
2021
accepted:
13
10
2021
pubmed:
31
10
2021
medline:
22
2
2022
entrez:
30
10
2021
Statut:
ppublish
Résumé
This study evaluated the postprandial effects following consumption of buckwheat, fava bean, pea, hemp and lupin compared to meat (beef); focussing on biomarkers of satiety, gut hormones, aminoacids and plant metabolites bioavailability and metabolism. Ten subjects (n = 3 men; n = 7 women; 42 ± 11.8 years of age; BMI 26 ± 5.8 kg/m Volunteers consumed significantly higher amounts of most amino acids from the meat meal, and with few exceptions, postprandial composition of plasma amino acids was not significantly different after consuming the plant-based meals. Buckwheat meal was the most satious (300 min hunger scores, p < 0.05).Significant increase in GLP-1 plasma (AUC, iAUC p = 0.01) found after hemp compared with the other plant-based meals. Decreased plasma ghrelin concentrations (iAUC p < 0.05) found on plant (hemp) vs. meat meal. Several plasma metabolites after hemp meal consumption were associated with hormone trends (partial least squares-discriminant analysis (PLS-DA): 4-hydroxyphenylpyruvic acid, indole 3-pyruvic acid, 5-hydoxytryptophan, genistein and biochanin A with GLP-1, PYY and insulin; 3-hydroxymandelic acid and luteolidin with GLP-1 and ghrelin and 4-hydroxymandelic acid, benzoic acid and secoisolariciresinol with insulin and ghrelin. Plasma branched-chain amino acids (BCAAs), (iAUC, p < 0.001); and phenylalanine and tyrosine (iAUC, p < 0.05) were lower after buckwheat comparison with meat meal. Plants are valuable sources of amino acids which are promoting satiety. The impact of hemp and buckwheat on GLP-1 and, respectively, BCAAs should be explored further as could be relevant for aid and prevention of chronic diseases such as type 2 diabetes. Study registered with clinicaltrial.gov on 12th July 2013, study ID number: NCT01898351.
Identifiants
pubmed: 34716790
doi: 10.1007/s00394-021-02711-z
pii: 10.1007/s00394-021-02711-z
pmc: PMC8854285
doi:
Substances chimiques
Amino Acids
0
Blood Glucose
0
Gastrointestinal Hormones
0
Ghrelin
0
Insulin
0
Banques de données
ClinicalTrials.gov
['NCT01898351']
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1057-1072Subventions
Organisme : Rural and Environment Science and Analytical Services Division
ID : The Scottish Government's Rural and Environment Science and Analytical Services Division (RESAS) via their strategic research and partnership programmes
Informations de copyright
© 2021. The Author(s).
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