Children and Adults in a Household Cohort Study Have Robust Longitudinal Immune Responses Following SARS-CoV-2 Infection or Exposure.
Adolescent
Adult
CD4-Positive T-Lymphocytes
/ immunology
CD8-Positive T-Lymphocytes
/ immunology
COVID-19
/ immunology
Child
Child, Preschool
Cohort Studies
Convalescence
Environmental Exposure
Family Characteristics
Female
Humans
Immunity, Cellular
Immunologic Memory
Infant
Male
Middle Aged
SARS-CoV-2
/ physiology
Young Adult
COVID - 19
cell profile
household contact
non-COVID-19 respiratory virus
pediatrics
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
15
07
2021
accepted:
21
09
2021
entrez:
1
11
2021
pubmed:
2
11
2021
medline:
11
11
2021
Statut:
epublish
Résumé
Children have reduced severity of COVID-19 compared to adults and typically have mild or asymptomatic disease. The immunological mechanisms underlying these age-related differences in clinical outcomes remain unexplained. Here, we quantify 23 immune cell populations in 141 samples from children and adults with mild COVID-19 and their PCR-negative close household contacts at acute and convalescent time points. Children with COVID-19 displayed marked reductions in myeloid cells during infection, most prominent in children under the age of five. Recovery from infection in both children and adults was characterised by the generation of CD8 T
Identifiants
pubmed: 34721408
doi: 10.3389/fimmu.2021.741639
pmc: PMC8548628
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
741639Informations de copyright
Copyright © 2021 Neeland, Bannister, Clifford, Nguyen, Dohle, Overmars, Toh, Anderson, Donato, Sarkar, Do, McCafferty, Licciardi, Ignjatovic, Monagle, Bines, Mulholland, Curtis, McNab, Steer, Burgner, Saffery, Tosif and Crawford.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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