Current malaria infection, previous malaria exposure, and clinical profiles and outcomes of COVID-19 in a setting of high malaria transmission: an exploratory cohort study in Uganda.
Journal
The Lancet. Microbe
ISSN: 2666-5247
Titre abrégé: Lancet Microbe
Pays: England
ID NLM: 101769019
Informations de publication
Date de publication:
Jan 2022
Jan 2022
Historique:
pubmed:
2
11
2021
medline:
2
11
2021
entrez:
1
11
2021
Statut:
ppublish
Résumé
The potential effects of SARS-CoV-2 and This was an exploratory prospective, cohort study of patients with COVID-19 who were admitted to hospital in Uganda. Patients of all ages with a PCR-confirmed diagnosis of SARS-CoV-2 infection who had provided informed consent or assent were consecutively enrolled from treatment centres in eight hospitals across the country and followed up until discharge or death. Clinical assessments and blood sampling were done at admission for all patients. Malaria diagnosis in all patients was done by rapid diagnostic tests, microscopy, and molecular methods. Previous Of 600 people with PCR-confirmed SARS-CoV-2 infection enrolled from April 15, to Oct 30, 2020, 597 (>99%) had complete information and were included in our analyses. The majority (502 [84%] of 597) were male individuals with a median age of 36 years (IQR 28-47). Overall prevalence of Although patients with COVID-19 with Malaria Consortium (USA).
Sections du résumé
BACKGROUND
BACKGROUND
The potential effects of SARS-CoV-2 and
METHODS
METHODS
This was an exploratory prospective, cohort study of patients with COVID-19 who were admitted to hospital in Uganda. Patients of all ages with a PCR-confirmed diagnosis of SARS-CoV-2 infection who had provided informed consent or assent were consecutively enrolled from treatment centres in eight hospitals across the country and followed up until discharge or death. Clinical assessments and blood sampling were done at admission for all patients. Malaria diagnosis in all patients was done by rapid diagnostic tests, microscopy, and molecular methods. Previous
FINDINGS
RESULTS
Of 600 people with PCR-confirmed SARS-CoV-2 infection enrolled from April 15, to Oct 30, 2020, 597 (>99%) had complete information and were included in our analyses. The majority (502 [84%] of 597) were male individuals with a median age of 36 years (IQR 28-47). Overall prevalence of
INTERPRETATION
CONCLUSIONS
Although patients with COVID-19 with
FUNDING
BACKGROUND
Malaria Consortium (USA).
Identifiants
pubmed: 34723228
doi: 10.1016/S2666-5247(21)00240-8
pii: S2666-5247(21)00240-8
pmc: PMC8545833
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
e62-e71Informations de copyright
© 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license.
Déclaration de conflit d'intérêts
HA and FN are members of the Mulago Hospital Research and Ethics but did not participate in decisions pertaining to this study. All other authors declare no competing interests.
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