A New Thienopyrimidinone Chemotype Shows Multistage Activity against Plasmodium falciparum, Including Artemisinin-Resistant Parasites.
Animals
Antimalarials
/ chemistry
Artemisinins
/ pharmacology
Cell Line, Tumor
Disease Models, Animal
Dogs
Drug Resistance
/ physiology
Female
Hep G2 Cells
Humans
Liver
/ parasitology
Macaca fascicularis
Madin Darby Canine Kidney Cells
Malaria, Falciparum
/ drug therapy
Male
Mice
Mice, Inbred BALB C
Plasmodium cynomolgi
/ drug effects
Plasmodium falciparum
/ drug effects
Plasmodium yoelii
/ drug effects
Pyrimidinones
/ chemistry
2-amino-6-phenyl-thienopyrimidin-4(3H)-one
antimalarials
artemisinin resistance
multistage activity
Journal
Microbiology spectrum
ISSN: 2165-0497
Titre abrégé: Microbiol Spectr
Pays: United States
ID NLM: 101634614
Informations de publication
Date de publication:
31 10 2021
31 10 2021
Historique:
entrez:
2
11
2021
pubmed:
3
11
2021
medline:
2
2
2022
Statut:
ppublish
Résumé
Human malaria infection begins with a one-time asymptomatic liver stage followed by a cyclic symptomatic blood stage. For decades, the research for novel antimalarials focused on the high-throughput screening of molecules that only targeted the asexual blood stages. In a search for new effective compounds presenting a triple action against erythrocytic and liver stages in addition to the ability to block the transmission of the disease
Identifiants
pubmed: 34724729
doi: 10.1128/Spectrum.00274-21
pmc: PMC8557901
doi:
Substances chimiques
Antimalarials
0
Artemisinins
0
Pyrimidinones
0
artemisinin
9RMU91N5K2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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