FtsK and SpoIIIE, coordinators of chromosome segregation and envelope remodeling in bacteria.
DNA translocases
FtsK
SpoIIIE
cell envelope
chromosome segregation
cytokinesis
Journal
Trends in microbiology
ISSN: 1878-4380
Titre abrégé: Trends Microbiol
Pays: England
ID NLM: 9310916
Informations de publication
Date de publication:
05 2022
05 2022
Historique:
received:
05
07
2021
revised:
05
10
2021
accepted:
06
10
2021
pubmed:
4
11
2021
medline:
15
4
2022
entrez:
3
11
2021
Statut:
ppublish
Résumé
The translocation of DNA during bacterial cytokinesis is mediated by the SpoIIIE/FtsK family of proteins. These proteins ensure efficient chromosome segregation into sister cells by ATP-driven translocation of DNA and they control chromosome dimer resolution. How FtsK/SpoIIIE mediate chromosome translocation during cytokinesis in Gram-positive and Gram-negative organisms has been the subject of debate. Studies on FtsK in Escherichia coli, and recent work on SpoIIIE in Bacillus subtilis, have identified interactions between each translocase and the division machinery, supporting the idea that SpoIIIE and FtsK coordinate the final steps of cytokinesis with completion of chromosome segregation. Here we summarize and discuss the view that SpoIIIE and FtsK play similar roles in coordinating cytokinesis with chromosome segregation, during growth and differentiation.
Identifiants
pubmed: 34728126
pii: S0966-842X(21)00242-0
doi: 10.1016/j.tim.2021.10.002
pii:
doi:
Substances chimiques
Bacterial Proteins
0
DNA, Bacterial
0
Escherichia coli Proteins
0
FtsK protein, E coli
0
Membrane Proteins
0
DNA
9007-49-2
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
480-494Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests There are no interests to declare.