The Impact of Age and Genetics on Naltrexone Biotransformation.
Journal
Drug metabolism and disposition: the biological fate of chemicals
ISSN: 1521-009X
Titre abrégé: Drug Metab Dispos
Pays: United States
ID NLM: 9421550
Informations de publication
Date de publication:
02 2022
02 2022
Historique:
received:
24
08
2021
accepted:
01
11
2021
pubmed:
4
11
2021
medline:
5
4
2022
entrez:
3
11
2021
Statut:
ppublish
Résumé
Naltrexone, an opioid antagonist primarily metabolized by aldo-keto reductase 1C4 (AKR1C4), treats pediatric conditions involving compulsiveness (e.g., autism spectrum, Prader-Willi, eating disorders, non-suicidal self-injury). Pharmacokinetic variability is apparent in adults, yet no data are available for children. This study aimed to examine the impact of age and genetic variation on naltrexone biotransformation. Human liver cytosol (HLC) samples (
Identifiants
pubmed: 34728519
pii: dmd.121.000646
doi: 10.1124/dmd.121.000646
pmc: PMC9621334
doi:
Substances chimiques
Narcotic Antagonists
0
Naltrexone
5S6W795CQM
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
168-173Subventions
Organisme : NICHD NIH HHS
ID : P50 HD090258
Pays : United States
Organisme : NICHD NIH HHS
ID : T32 HD069038
Pays : United States
Organisme : NICHD NIH HHS
ID : U54 HD090258
Pays : United States
Informations de copyright
Copyright © 2022 by The American Society for Pharmacology and Experimental Therapeutics.
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