Adolescent Binge Drinking Is Associated With Accelerated Decline of Gray Matter Volume.
adolescence
alcohol
binge drinking
brain development
cortical volume
Journal
Cerebral cortex (New York, N.Y. : 1991)
ISSN: 1460-2199
Titre abrégé: Cereb Cortex
Pays: United States
ID NLM: 9110718
Informations de publication
Date de publication:
07 06 2022
07 06 2022
Historique:
received:
13
04
2021
revised:
27
08
2021
accepted:
28
08
2021
pubmed:
4
11
2021
medline:
18
6
2022
entrez:
3
11
2021
Statut:
ppublish
Résumé
The age- and time-dependent effects of binge drinking on adolescent brain development have not been well characterized even though binge drinking is a health crisis among adolescents. The impact of binge drinking on gray matter volume (GMV) development was examined using 5 waves of longitudinal data from the National Consortium on Alcohol and NeuroDevelopment in Adolescence study. Binge drinkers (n = 166) were compared with non-binge drinkers (n = 82 after matching on potential confounders). Number of binge drinking episodes in the past year was linked to decreased GMVs in bilateral Desikan-Killiany cortical parcellations (26 of 34 with P < 0.05/34) with the strongest effects observed in frontal regions. Interactions of binge drinking episodes and baseline age demonstrated stronger effects in younger participants. Statistical models sensitive to number of binge episodes and their temporal proximity to brain volumes provided the best fits. Consistent with prior research, results of this study highlight the negative effects of binge drinking on the developing brain. Our results present novel findings that cortical GMV decreases were greater in closer proximity to binge drinking episodes in a dose-response manner. This relation suggests a causal effect and raises the possibility that normal growth trajectories may be reinstated with alcohol abstinence.
Identifiants
pubmed: 34729592
pii: 6419841
doi: 10.1093/cercor/bhab368
pmc: PMC9201595
doi:
Substances chimiques
Ethanol
3K9958V90M
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
2611-2620Subventions
Organisme : NIAAA NIH HHS
ID : U01 AA021691
Pays : United States
Organisme : NIAAA NIH HHS
ID : U24 AA021697
Pays : United States
Organisme : NIAAA NIH HHS
ID : U24 AA021695
Pays : United States
Organisme : NIAAA NIH HHS
ID : U01 AA021692
Pays : United States
Organisme : NIAAA NIH HHS
ID : U01 AA021696
Pays : United States
Organisme : NIAAA NIH HHS
ID : U01 AA021681
Pays : United States
Organisme : NIAAA NIH HHS
ID : U01 AA021690
Pays : United States
Informations de copyright
© The Author(s) 2021. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
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