MbnC Is Not Required for the Formation of the N-Terminal Oxazolone in the Methanobactin from Methylosinus trichosporium OB3b.

aerobic methane oxidation chalkophore methanobactin methanotroph ribosomally synthesized and posttranslational modified peptide

Journal

Applied and environmental microbiology
ISSN: 1098-5336
Titre abrégé: Appl Environ Microbiol
Pays: United States
ID NLM: 7605801

Informations de publication

Date de publication:
25 01 2022
Historique:
pubmed: 4 11 2021
medline: 25 3 2022
entrez: 3 11 2021
Statut: ppublish

Résumé

Methanobactins (MBs) are ribosomally synthesized and posttranslationally modified peptides (RiPPs) produced by methanotrophs for copper uptake. The posttranslational modification that defines MBs is the formation of two heterocyclic groups with associated thioamines from X-Cys dipeptide sequences. Both heterocyclic groups in the MB from Methylosinus trichosporium OB3b (MB-OB3b) are oxazolone groups. The precursor gene for MB-OB3b is

Identifiants

pubmed: 34731053
doi: 10.1128/AEM.01841-21
pmc: PMC8788703
doi:

Substances chimiques

Imidazoles 0
Oligopeptides 0
methanobactin 0
Oxazolone 15646-46-5
Copper 789U1901C5
Oxygenases EC 1.13.-

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

e0184121

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Auteurs

Philip Dershwitz (P)

Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State Universitygrid.34421.30, Ames, Iowa, USA.

Wenyu Gu (W)

Department of Civil and Environmental Engineering, University of Michigan, Ann Arbor, Michigan, USA.

Julien Roche (J)

Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State Universitygrid.34421.30, Ames, Iowa, USA.

Christina S Kang-Yun (CS)

Department of Civil and Environmental Engineering, University of Michigan, Ann Arbor, Michigan, USA.

Jeremy D Semrau (JD)

Department of Civil and Environmental Engineering, University of Michigan, Ann Arbor, Michigan, USA.

Thomas A Bobik (TA)

Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State Universitygrid.34421.30, Ames, Iowa, USA.

Bruce Fulton (B)

Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State Universitygrid.34421.30, Ames, Iowa, USA.

Hans Zischka (H)

Institute of Molecular Toxicology and Pharmacology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany.
Technical University Münich, School of Medicine, Institute of Toxicology and Environmental Hygiene, Munich, Germany.

Alan A DiSpirito (AA)

Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State Universitygrid.34421.30, Ames, Iowa, USA.

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Classifications MeSH