The sooner the better: clinical and neural correlates of impulsive choice in Tourette disorder.
Journal
Translational psychiatry
ISSN: 2158-3188
Titre abrégé: Transl Psychiatry
Pays: United States
ID NLM: 101562664
Informations de publication
Date de publication:
03 11 2021
03 11 2021
Historique:
received:
09
08
2021
accepted:
20
10
2021
revised:
15
10
2021
entrez:
4
11
2021
pubmed:
5
11
2021
medline:
1
2
2022
Statut:
epublish
Résumé
Reward sensitivity has been suggested as one of the central pathophysiological mechanisms in Tourette disorder. However, the subjective valuation of a reward by introduction of delay has received little attention in Tourette disorder, even though it has been suggested as a trans-diagnostic feature of numerous neuropsychiatric disorders. We aimed to assess delay discounting in Tourette disorder and to identify its brain functional correlates. We evaluated delayed discounting and its brain functional correlates in a large group of 54 Tourette disorder patients and 31 healthy controls using a data-driven approach. We identified a subgroup of 29 patients with steeper reward discounting, characterised by a higher burden of impulse-control disorders and a higher level of general impulsivity compared to patients with normal behavioural performance or to controls. Reward discounting was underpinned by resting-state activity of a network comprising the orbito-frontal, cingulate, pre-supplementary motor area, temporal and insular cortices, as well as ventral striatum and hippocampus. Within this network, (i) lower connectivity of pre-supplementary motor area with ventral striatum predicted a higher impulsivity and a steeper reward discounting and (ii) a greater connectivity of pre-supplementary motor area with anterior insular cortex predicted steeper reward discounting and more severe tics. Overall, our results highlight the heterogeneity of the delayed reward processing in Tourette disorder, with steeper reward discounting being a marker of burden in impulsivity and impulse control disorders, and the pre-supplementary motor area being a hub region for the delay discounting, impulsivity and tic severity.
Identifiants
pubmed: 34732691
doi: 10.1038/s41398-021-01691-2
pii: 10.1038/s41398-021-01691-2
pmc: PMC8566507
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
560Informations de copyright
© 2021. The Author(s).
Références
Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16187-92
pubmed: 24038744
Brain Sci. 2019 Dec 16;9(12):
pubmed: 31888218
Psychon Bull Rev. 1996 Mar;3(1):100-4
pubmed: 24214810
Front Neurosci. 2014 Mar 18;8:50
pubmed: 24672421
Brain. 2019 Jan 1;142(1):146-162
pubmed: 30590514
Neurosci Biobehav Rev. 2020 Jan;108:295-307
pubmed: 31778679
JAMA Psychiatry. 2019 Nov 1;76(11):1176-1186
pubmed: 31461131
J Neurosci. 2015 Feb 18;35(7):3010-5
pubmed: 25698738
Neuroimage. 2009 Mar 1;45(1):143-50
pubmed: 19071223
Clin Psychol Rev. 2016 Feb;43:162-74
pubmed: 26602954
Addiction. 2018 Dec;113(12):2173-2181
pubmed: 30047179
Brain. 2018 Nov 1;141(11):3249-3261
pubmed: 30346484
Curr Top Behav Neurosci. 2020;47:113-138
pubmed: 32236897
Science. 2004 Oct 15;306(5695):503-7
pubmed: 15486304
Neuroimage. 2012 Apr 15;60(3):1759-70
pubmed: 22209809
Curr Opin Neurol. 2016 Aug;29(4):513-8
pubmed: 27310537
J Neurophysiol. 2010 May;103(5):2513-31
pubmed: 20181737
Mol Psychiatry. 2021 Jul;26(7):3548-3557
pubmed: 32994553
J Clin Psychiatry. 1998;59 Suppl 20:22-33;quiz 34-57
pubmed: 9881538
Methods Mol Biol. 2009;489:23-40
pubmed: 18839086
Cortex. 2020 May;126:119-133
pubmed: 32070809
Int Rev Neurobiol. 2018;143:65-108
pubmed: 30473198
PLoS One. 2021 Jun 18;16(6):e0253620
pubmed: 34143854
J Neurosci. 2010 Jun 30;30(26):8888-96
pubmed: 20592211
Proc Natl Acad Sci U S A. 2009 Nov 10;106(45):19179-84
pubmed: 19850878
Physiol Rev. 2015 Jul;95(3):853-951
pubmed: 26109341
Neuropsychologia. 2020 Jul;144:107492
pubmed: 32437762
Brain. 2019 Nov 1;142(11):3530-3549
pubmed: 31549164
Depress Anxiety. 2017 May;34(5):463-470
pubmed: 28009473
J Exp Psychol Anim Learn Cogn. 2016 Apr;42(2):141-62
pubmed: 26881899
Int Rev Neurobiol. 2013;112:131-53
pubmed: 24295620
Arch Gen Psychiatry. 2011 Dec;68(12):1257-66
pubmed: 22147843
Prog Neurobiol. 2013 Sep;108:44-79
pubmed: 23856628
Cogn Affect Behav Neurosci. 2018 Aug;18(4):694-704
pubmed: 29696595
Biol Psychiatry. 2018 Sep 1;84(5):332-344
pubmed: 29656800
Neurosci Biobehav Rev. 2017 Aug;79:48-65
pubmed: 28465167
Behav Neurosci. 2017 Feb;131(1):11-19
pubmed: 28004949
J Neurosci. 2018 Mar 7;38(10):2471-2481
pubmed: 29440536
PLoS Comput Biol. 2017 Mar 30;13(3):e1005395
pubmed: 28358814
Prog Neuropsychopharmacol Biol Psychiatry. 2020 Apr 20;99:109822
pubmed: 31751662
Mov Disord. 2020 Jul;35(7):1279-1280
pubmed: 32392365
Sci Rep. 2020 Jan 20;10(1):716
pubmed: 31959838
Brain. 2011 Aug;134(Pt 8):2287-301
pubmed: 21727098
Neurobiol Learn Mem. 2016 Sep;133:233-256
pubmed: 27427327
J Clin Psychol. 1995 Nov;51(6):768-74
pubmed: 8778124
Psychopharmacology (Berl). 2021 Mar;238(3):711-723
pubmed: 33215269
Neuropsychiatr Dis Treat. 2015 Jun 11;11:1431-6
pubmed: 26089672
Br J Med Psychol. 1959;32(1):50-5
pubmed: 13638508
Psychopharmacology (Berl). 2008 Dec;201(2):183-93
pubmed: 18685833
J Am Acad Child Adolesc Psychiatry. 1989 Jul;28(4):566-73
pubmed: 2768151
Behav Processes. 2019 May;162:157-161
pubmed: 30876880