Sitosterol and glucosylceramide cooperative transversal and lateral uneven distribution in plant membranes.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
03 11 2021
03 11 2021
Historique:
received:
29
07
2021
accepted:
05
10
2021
entrez:
4
11
2021
pubmed:
5
11
2021
medline:
28
1
2022
Statut:
epublish
Résumé
The properties of biomembranes depend on the presence, local structure and relative distribution assumed by the thousands of components it is made of. As for animal cells, plant membranes have been demonstrated to be organized in subdomains with different persistence lengths and times. In plant cells, sitosterol has been demonstrated to confer to phospholipid membranes a more ordered structure while among lipids, glycosphingolipids are claimed to form rafts where they tightly pack with sterols. Glucosylceramides are glycosphingolipids involved in plant signalling and are essential for viability of cells and whole plant. The glucosylceramide-sitosterol structural coupling within PLPC membranes is here investigated by Langmuir films, in silico simulations and neutron reflectometry, unveiling that a strong direct interaction between the two molecules exists and governs their lateral and transversal distribution within membrane leaflets. The understanding of the driving forces governing specific molecules clustering and segregation in subdomains, such as glucosylceramide and sitosterol, have an impact on the mechanical properties of biomembranes and could reflect in the other membrane molecules partitioning and activity.
Identifiants
pubmed: 34732753
doi: 10.1038/s41598-021-00696-7
pii: 10.1038/s41598-021-00696-7
pmc: PMC8566578
doi:
Substances chimiques
Glucosylceramides
0
Lipid Bilayers
0
Sitosterols
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
21618Subventions
Organisme : Università degli Studi di Milano
ID : PSR2018
Organisme : Università degli Studi di Milano
ID : PSR2019
Organisme : FWO/F.R.S.-FNRS
ID : EOS project ID30650620
Organisme : FRIA (Fonds pour la formation à la Recherche dans l'Industrie et dans l'Agriculture)
ID : 5100617F
Organisme : FRS-FNRS (Fonds National de la Recherche Scientifique, Belgium)
ID : CDR grants number J.0014.08
Organisme : FRS-FNRS (Fonds National de la Recherche Scientifique, Belgium)
ID : J.0086.18
Organisme : FRS-FNRS (Fonds National de la Recherche Scientifique, Belgium)
ID : PDR grant number T.0063.19
Informations de copyright
© 2021. The Author(s).
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