MC3R links nutritional state to childhood growth and the timing of puberty.

Adolescent Aged, 80 and over Animals Child Child Development / physiology Estrous Cycle / genetics Female Homozygote Humans Hypothalamus / cytology Insulin-Like Growth Factor I / metabolism Male Melanocortins / metabolism Menarche / genetics Mice Nutritional Status / physiology Phenotype Puberty / genetics Receptor, Melanocortin, Type 3 / deficiency Sexual Maturation / genetics Time Factors Weight Gain

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
11 2021
Historique:
received: 17 12 2020
accepted: 01 10 2021
pubmed: 5 11 2021
medline: 29 3 2022
entrez: 4 11 2021
Statut: ppublish

Résumé

The state of somatic energy stores in metazoans is communicated to the brain, which regulates key aspects of behaviour, growth, nutrient partitioning and development

Identifiants

DOI: 10.1038/s41586-021-04088-9 PMID: 34732894 PMC: PMC8819628
pubmed: 34732894
doi: 10.1038/s41586-021-04088-9
pii: 10.1038/s41586-021-04088-9
pmc: PMC8819628
mid: NIHMS1771752
doi:

Substances chimiques

IGF1 protein, human 0
MC3R protein, human 0
Mc3r protein, mouse 0
Melanocortins 0
Receptor, Melanocortin, Type 3 0
Insulin-Like Growth Factor I 67763-96-6

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

436-441

Subventions

Organisme : Medical Research Council
ID : MC_UU_00006/1
Pays : United Kingdom
Organisme : NICHD NIH HHS
ID : F32 HD105386
Pays : United States
Organisme : Medical Research Council
ID : MC_UU_12015/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N003284/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_15018
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12015/2
Pays : United Kingdom
Organisme : NIDDK NIH HHS
ID : R01 DK126715
Pays : United States
Organisme : Medical Research Council
ID : G0401527
Pays : United Kingdom
Organisme : NIDDK NIH HHS
ID : K99 DK127065
Pays : United States
Organisme : Medical Research Council
ID : G1000143
Pays : United Kingdom
Organisme : NIDDK NIH HHS
ID : F32 DK123879
Pays : United States
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00014/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12012/5
Pays : United Kingdom
Organisme : NICHD NIH HHS
ID : F32 HD095620
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK070332
Pays : United States
Organisme : Medical Research Council
ID : MC_UU_00006/2
Pays : United Kingdom
Organisme : Cancer Research UK
ID : 14136
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00014/5
Pays : United Kingdom
Organisme : NIDDK NIH HHS
ID : R01 DK106476
Pays : United States
Organisme : Medical Research Council
ID : MC_UU_12012/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : G9815508
Pays : United Kingdom

Commentaires et corrections

Type : CommentIn
Type : CommentIn

Informations de copyright

© 2021. The Author(s), under exclusive licence to Springer Nature Limited.

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Auteurs

B Y H Lam (BYH)

MRC Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
NIHR Cambridge Biomedical Research Centre, Cambridge, UK.
ORCID: 0000-0002-3638-9025

A Williamson (A)

MRC Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
NIHR Cambridge Biomedical Research Centre, Cambridge, UK.
MRC Epidemiology Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
ORCID: 0000-0002-7599-9301

S Finer (S)

Wolfson Institute of Population Health, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
ORCID: 0000-0002-2684-4653

F R Day (FR)

MRC Epidemiology Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
ORCID: 0000-0003-3789-7651

J A Tadross (JA)

MRC Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
NIHR Cambridge Biomedical Research Centre, Cambridge, UK.
Department of Pathology, University of Cambridge, Cambridge, UK.
ORCID: 0000-0002-8424-1252

A Gonçalves Soares (A)

MRC Integrative Epidemiology Unit and Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.

K Wade (K)

MRC Integrative Epidemiology Unit and Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
ORCID: 0000-0003-3362-6280

P Sweeney (P)

Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.

M N Bedenbaugh (MN)

Department of Molecular Physiology and Biophysics, School of Medicine, Vanderbilt University, Nashville, TN, USA.

D T Porter (DT)

Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.
ORCID: 0000-0002-8042-3251

A Melvin (A)

MRC Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
NIHR Cambridge Biomedical Research Centre, Cambridge, UK.

K L J Ellacott (KLJ)

Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, Exeter, UK.

R N Lippert (RN)

Department of Neurocircuit Development and Function, German Institute of Human Nutrition, Potsdam, Germany.

S Buller (S)

MRC Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
NIHR Cambridge Biomedical Research Centre, Cambridge, UK.

J Rosmaninho-Salgado (J)

Medical Genetics Unit, Hospital Pediátrico, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.

G K C Dowsett (GKC)

MRC Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
NIHR Cambridge Biomedical Research Centre, Cambridge, UK.

K E Ridley (KE)

Department of Paediatrics, University of Cambridge, Cambridge, UK.

Z Xu (Z)

Department of Paediatrics, University of Cambridge, Cambridge, UK.

I Cimino (I)

MRC Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
NIHR Cambridge Biomedical Research Centre, Cambridge, UK.
ORCID: 0000-0003-1397-5408

D Rimmington (D)

MRC Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
NIHR Cambridge Biomedical Research Centre, Cambridge, UK.

K Rainbow (K)

MRC Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
NIHR Cambridge Biomedical Research Centre, Cambridge, UK.

K Duckett (K)

MRC Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
NIHR Cambridge Biomedical Research Centre, Cambridge, UK.

S Holmqvist (S)

Department of Paediatrics, University of Cambridge, Cambridge, UK.
ORCID: 0000-0001-6709-6666

A Khan (A)

Wolfson Institute of Population Health, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
ORCID: 0000-0002-5189-6906

X Dai (X)

Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University London, London, UK.

E G Bochukova (EG)

Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University London, London, UK.

R C Trembath (RC)

School of Basic and Medical Biosciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.

H C Martin (HC)

Wellcome Sanger Institute, Hinxton, Cambridge, UK.
ORCID: 0000-0002-4454-9084

A P Coll (AP)

MRC Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
NIHR Cambridge Biomedical Research Centre, Cambridge, UK.

D H Rowitch (DH)

Department of Paediatrics, University of Cambridge, Cambridge, UK.
ORCID: 0000-0002-0079-0060

N J Wareham (NJ)

MRC Epidemiology Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
ORCID: 0000-0003-1422-2993

D A van Heel (DA)

Wolfson Institute of Population Health, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University London, London, UK.
ORCID: 0000-0002-0637-2265

N Timpson (N)

MRC Integrative Epidemiology Unit and Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
ORCID: 0000-0002-7141-9189

R B Simerly (RB)

Department of Molecular Physiology and Biophysics, School of Medicine, Vanderbilt University, Nashville, TN, USA.
ORCID: 0000-0001-5840-0152

K K Ong (KK)

MRC Epidemiology Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
Department of Paediatrics, University of Cambridge, Cambridge, UK.
ORCID: 0000-0003-4689-7530

R D Cone (RD)

Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.
Department of Molecular and Integrative Physiology, School of Medicine, University of Michigan, Ann Arbor, MI, USA.
ORCID: 0000-0003-3333-5651

C Langenberg (C)

MRC Epidemiology Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
Computational Medicine, Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany.
ORCID: 0000-0002-5017-7344

J R B Perry (JRB)

MRC Epidemiology Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
ORCID: 0000-0001-6483-3771

G S Yeo (GS)

MRC Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
NIHR Cambridge Biomedical Research Centre, Cambridge, UK.
ORCID: 0000-0001-8823-3615

S O'Rahilly (S)

MRC Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK. so104@medschl.cam.ac.uk.
NIHR Cambridge Biomedical Research Centre, Cambridge, UK. so104@medschl.cam.ac.uk.
ORCID: 0000-0003-2199-4449

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adolescent › MC3R links nutritional state to childhood...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Sujet âgé de 80 ans ou plus › MC3R links nutritional state to childhood...
questionsmedicales.fr › Eucaryotes › Animaux › MC3R links nutritional state to childhood...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › MC3R links nutritional state to childhood...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Développement humain › Développement de l'enfant › MC3R links nutritional state to childhood...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Cycle oestral › MC3R links nutritional state to childhood...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Homozygote › MC3R links nutritional state to childhood...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › MC3R links nutritional state to childhood...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Diencéphale › Hypothalamus › MC3R links nutritional state to childhood...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Somatomédines › Facteur de croissance IGF-I › MC3R links nutritional state to childhood...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Neuropeptides › Hormones hypothalamiques › Mélanocortines › MC3R links nutritional state to childhood...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Développement sexuel › Puberté › Ménarche › MC3R links nutritional state to childhood...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › MC3R links nutritional state to childhood...
questionsmedicales.fr › Caractéristiques de la population › État nutritionnel › MC3R links nutritional state to childhood...
questionsmedicales.fr › Phénomènes génétiques › Phénotype › MC3R links nutritional state to childhood...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Développement sexuel › Puberté › MC3R links nutritional state to childhood...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur hormone hypophysaire › Récepteur corticotrophine › Récepteurs à la mélanocortine › Récepteur de la mélanocortine de type 3 › MC3R links nutritional state to childhood...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Développement sexuel › Maturation sexuelle › MC3R links nutritional state to childhood...
questionsmedicales.fr › Phénomènes physiques › Temps › Facteurs temps › MC3R links nutritional state to childhood...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Mensurations corporelles › Poids › Modifications du poids corporel › Prise de poids › MC3R links nutritional state to childhood...