An altered balance of integrated and segregated brain activity is a marker of cognitive deficits following sleep deprivation.
Journal
PLoS biology
ISSN: 1545-7885
Titre abrégé: PLoS Biol
Pays: United States
ID NLM: 101183755
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
received:
14
04
2021
accepted:
28
09
2021
entrez:
4
11
2021
pubmed:
5
11
2021
medline:
22
12
2021
Statut:
epublish
Résumé
Sleep deprivation (SD) leads to impairments in cognitive function. Here, we tested the hypothesis that cognitive changes in the sleep-deprived brain can be explained by information processing within and between large-scale cortical networks. We acquired functional magnetic resonance imaging (fMRI) scans of 20 healthy volunteers during attention and executive tasks following a regular night of sleep, a night of SD, and a recovery nap containing nonrapid eye movement (NREM) sleep. Overall, SD was associated with increased cortex-wide functional integration, driven by a rise of integration within cortical networks. The ratio of within versus between network integration in the cortex increased further in the recovery nap, suggesting that prolonged wakefulness drives the cortex towards a state resembling sleep. This balance of integration and segregation in the sleep-deprived state was tightly associated with deficits in cognitive performance. This was a distinct and better marker of cognitive impairment than conventional indicators of homeostatic sleep pressure, as well as the pronounced thalamocortical connectivity changes that occurs towards falling asleep. Importantly, restoration of the balance between segregation and integration of cortical activity was also related to performance recovery after the nap, demonstrating a bidirectional effect. These results demonstrate that intra- and interindividual differences in cortical network integration and segregation during task performance may play a critical role in vulnerability to cognitive impairment in the sleep-deprived state.
Identifiants
pubmed: 34735431
doi: 10.1371/journal.pbio.3001232
pii: PBIOLOGY-D-21-01005
pmc: PMC8568176
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e3001232Subventions
Organisme : CIHR
ID : MOP 142191
Pays : Canada
Organisme : CIHR
ID : PJT 153115
Pays : Canada
Organisme : CIHR
ID : PJT 156125
Pays : Canada
Organisme : CIHR
ID : PJT 166167
Pays : Canada
Organisme : CIHR
ID : PJT-159948
Pays : Canada
Organisme : CIHR
ID : MOP-133619
Pays : Canada
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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