A genetic screen in macrophages identifies new regulators of IFNγ-inducible MHCII that contribute to T cell activation.
CD4+ T cell activation
IFN-gamma
MHCII expression
immunology
inflammation
macrophages
mouse
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
08 11 2021
08 11 2021
Historique:
received:
23
11
2020
accepted:
03
11
2021
pubmed:
9
11
2021
medline:
15
12
2021
entrez:
8
11
2021
Statut:
epublish
Résumé
Cytokine-mediated activation of host immunity is central to the control of pathogens. Interferon-gamma (IFNγ) is a key cytokine in protective immunity that induces major histocompatibility complex class II molecules (MHCII) to amplify CD4
Identifiants
pubmed: 34747695
doi: 10.7554/eLife.65110
pii: 65110
pmc: PMC8598162
doi:
pii:
Substances chimiques
Histocompatibility Antigens Class II
0
MHC class II transactivator protein
0
Nuclear Proteins
0
Trans-Activators
0
Interferon-gamma
82115-62-6
Banques de données
GEO
['GSE162463', 'GSE162464']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : P01 AI132130
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI146504
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI095213
Pays : United States
Informations de copyright
© 2021, Kiritsy et al.
Déclaration de conflit d'intérêts
MK, LA, JT, GH, AL, PO, RE, KF, AO No competing interests declared
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