Maternal dopamine encodes affective signals of human infants.
D2/3 receptors
affect
allostasis-regulation
infant behavior
maternal brain
nucleus accumbens
Journal
Social cognitive and affective neuroscience
ISSN: 1749-5024
Titre abrégé: Soc Cogn Affect Neurosci
Pays: England
ID NLM: 101288795
Informations de publication
Date de publication:
05 05 2022
05 05 2022
Historique:
received:
05
11
2020
revised:
24
09
2021
accepted:
08
11
2021
pubmed:
10
11
2021
medline:
10
5
2022
entrez:
9
11
2021
Statut:
ppublish
Résumé
Mothers are highly responsive to their offspring. In non-human mammals, mothers secrete dopamine in the nucleus accumbens (NAcc) in response to their pups. Yet, it is still unknown which aspect of the offspring behavior elicits dopaminergic responses in mothers. Here, we tested whether infants' affective signals elicit dopaminergic responses in the NAcc of human mothers. First, we conducted a behavioral analysis on videos of infants' free play and quantified the affective signals infants spontaneously communicated. Then, we presented the same videos to mothers during a magnetic resonance-positron emission tomography scan. We traced the binding of [11C]raclopride to free D2/3-type receptors to assess maternal dopaminergic responses during the infant videos. When mothers observed videos with many infant signals during the scan, they had less [11C]raclopride binding in the right NAcc. Less [11C]raclopride binding indicates that less D2/3 receptors were free, possibly due to increased endogenous dopamine responses to infants' affective signals. We conclude that NAcc D2/3 receptors are involved in maternal responsiveness to affective signals of human infants. D2/3 receptors have been associated with maternal responsiveness in nonhuman animals. This evidence supports a similar mechanism in humans and specifies infant-behaviors that activate the maternal dopaminergic system, with implications for social neuroscience, development and psychopathology.
Identifiants
pubmed: 34750627
pii: 6423727
doi: 10.1093/scan/nsab116
pmc: PMC9071406
doi:
Substances chimiques
Receptors, Dopamine D2
0
Raclopride
430K3SOZ7G
Dopamine
VTD58H1Z2X
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
503-509Subventions
Organisme : NICHD NIH HHS
ID : R21HD076164
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB014894
Pays : United States
Informations de copyright
© The Author(s) 2021. Published by Oxford University Press.
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