Extrachromosomal DNA: An Emerging Hallmark in Human Cancer.
cancer genomics
ecDNA
extrachromosomal DNA
gene amplification
non-Mendelian inheritance
tumor evolution
Journal
Annual review of pathology
ISSN: 1553-4014
Titre abrégé: Annu Rev Pathol
Pays: United States
ID NLM: 101275111
Informations de publication
Date de publication:
24 01 2022
24 01 2022
Historique:
pubmed:
10
11
2021
medline:
11
3
2022
entrez:
9
11
2021
Statut:
ppublish
Résumé
Human genes are arranged on 23 pairs of chromosomes, but in cancer, tumor-promoting genes and regulatory elements can free themselves from chromosomes and relocate to circular, extrachromosomal pieces of DNA (ecDNA). ecDNA, because of its nonchromosomal inheritance, drives high-copy-number oncogene amplification and enables tumors to evolve their genomes rapidly. Furthermore, the circular ecDNA architecture fundamentally alters gene regulation and transcription, and the higher-order organization of ecDNA contributes to tumor pathogenesis. Consequently, patients whose cancers harbor ecDNA have significantly shorter survival. Although ecDNA was first observed more than 50 years ago, its critical importance has only recently come to light. In this review, we discuss the current state of understanding of how ecDNAs form and function as well as how they contribute to drug resistance and accelerated cancer evolution.
Identifiants
pubmed: 34752712
doi: 10.1146/annurev-pathmechdis-051821-114223
pmc: PMC9125980
mid: NIHMS1807975
doi:
Substances chimiques
DNA
9007-49-2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
367-386Subventions
Organisme : NCI NIH HHS
ID : R01 CA238249
Pays : United States
Organisme : NCI NIH HHS
ID : U24 CA264379
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS073831
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM114362
Pays : United States
Organisme : NCI NIH HHS
ID : R35 CA209919
Pays : United States
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