Adipose Tissue, White
/ metabolism
Aged
Calibration
Ceramides
/ chemistry
Chemical Fractionation
Ethanolamines
/ chemistry
Fatty Acids, Unsaturated
/ metabolism
Female
Humans
Lipidomics
Lipids
/ isolation & purification
Male
Middle Aged
Phenotype
Plasmalogens
/ metabolism
Triglycerides
/ metabolism
Up-Regulation
LC-MS/MS
ceramides
human white adipose tissue
lipid identification
lipid metabolism
lipidomics
obesity
plasmalogens
semi-absolute lipid quantification
sphingolipids
subcutaneous white adipose tissue
triacylglycerols
visceral white adipose tissue
Journal
Cell reports. Medicine
ISSN: 2666-3791
Titre abrégé: Cell Rep Med
Pays: United States
ID NLM: 101766894
Informations de publication
Date de publication:
19 10 2021
19 10 2021
Historique:
received:
11
03
2021
revised:
29
07
2021
accepted:
26
08
2021
entrez:
10
11
2021
pubmed:
11
11
2021
medline:
11
11
2021
Statut:
epublish
Résumé
Obesity, characterized by expansion and metabolic dysregulation of white adipose tissue (WAT), has reached pandemic proportions and acts as a primer for a wide range of metabolic disorders. Remodeling of WAT lipidome in obesity and associated comorbidities can explain disease etiology and provide valuable diagnostic and prognostic markers. To support understanding of WAT lipidome remodeling at the molecular level, we provide in-depth lipidomics profiling of human subcutaneous and visceral WAT of lean and obese individuals. We generate a human WAT reference lipidome by performing tissue-tailored preanalytical and analytical workflows, which allow accurate identification and semi-absolute quantification of 1,636 and 737 lipid molecular species, respectively. Deep lipidomic profiling allows identification of main lipid (sub)classes undergoing depot-/phenotype-specific remodeling. Previously unanticipated diversity of WAT ceramides is now uncovered.
Identifiants
pubmed: 34755127
doi: 10.1016/j.xcrm.2021.100407
pii: S2666-3791(21)00265-2
pmc: PMC8561168
doi:
Substances chimiques
Ceramides
0
Ethanolamines
0
Fatty Acids, Unsaturated
0
Lipids
0
Plasmalogens
0
Triglycerides
0
sphingadienine
25696-03-1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
100407Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2021 The Author(s).
Déclaration de conflit d'intérêts
M.B. received honoraria as a consultant and speaker from Amgen, AstraZeneca, Bayer, Boehringer-Ingelheim, Lilly, Novo Nordisk, Novartis, and Sanofi. All other authors declare no competing interests.
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