Hyperosmolar hyperglycemic coma in an infant with neonatal diabetes mellitus.
Diabetes mellitus
Diabetic ketoacidosis
Hyperglycemic hyperosmolar nonketotic coma
Pediatric emergency medicine
Permanent neonatal
Journal
The American journal of emergency medicine
ISSN: 1532-8171
Titre abrégé: Am J Emerg Med
Pays: United States
ID NLM: 8309942
Informations de publication
Date de publication:
Apr 2022
Apr 2022
Historique:
received:
12
08
2021
revised:
18
10
2021
accepted:
18
10
2021
pubmed:
11
11
2021
medline:
9
4
2022
entrez:
10
11
2021
Statut:
ppublish
Résumé
Neonatal diabetes mellitus (NDM) is a rare disease distinct from type 1 diabetes mellitus (T1DM). While T1DM results from autoimmune destruction of pancreatic beta cells, NDM arises from genetic mutations to insulin production and secretion pathways. We present a case of an infant presenting to the emergency department with shock and poor responsiveness, found to have neonatal DM with hyperosmotic hyperglycemic syndrome (HHS). This report distinguishes NDM from T1DM, illustrating the subtle but clinically significant differences in pathophysiology and implications for initial management of NDM in the emergency department setting.
Identifiants
pubmed: 34756479
pii: S0735-6757(21)00861-5
doi: 10.1016/j.ajem.2021.10.026
pii:
doi:
Substances chimiques
Insulin
0
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
327.e5-327.e6Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.