Mitogenomics of modern Mongolic-speaking populations.
Barghuts
Buryats
Genetic components
Genetic diversity
Haplogroups
Khamnigans
Mitochondrial DNA phylogeny
Mitochondrial genomes
Molecular phylogeography
Mongols
Journal
Molecular genetics and genomics : MGG
ISSN: 1617-4623
Titre abrégé: Mol Genet Genomics
Pays: Germany
ID NLM: 101093320
Informations de publication
Date de publication:
Jan 2022
Jan 2022
Historique:
received:
11
03
2021
accepted:
27
10
2021
pubmed:
11
11
2021
medline:
8
2
2022
entrez:
10
11
2021
Statut:
ppublish
Résumé
Here, we present a comprehensive data set of 489 complete mitogenomes (211 of which are new) from four Mongolic-speaking populations (Mongols, Barghuts, Khamnigans, and Buryats) to investigate their matrilineal genetic structure, ancestry and relationship with other ethnic groups. We show that along with very high levels of genetic diversity and lack of genetic differentiation, Mongolic-speaking populations exhibit strong genetic resemblance to East Asian populations of Chinese, Japanese, and Uyghurs. Phylogeographic analysis of complete mitogenomes reveals the presence of different components in the gene pools of modern Mongolic-speaking populations-the main East Eurasian component is represented by mtDNA lineages of East Asian, Siberian and autochthonous (the Baikal region/Mongolian) ancestry, whereas the less pronounced West Eurasian component can be ascribed to Europe and West Asia/Caucasus. We also observed that up to one third of the mtDNA subhaplogroups identified in Mongolic-speaking populations can be considered as Mongolic-specific with the coalescence age of most of them not exceeding 1.7 kya. This coincides well with the population size growth which started around 1.1 kya and is detectable only in the Bayesian Skyline Plot constructed based on Mongolic-specific mitogenomes. Our data suggest that the genetic structure established during the Mongol empire is still retained in present-day Mongolic-speaking populations.
Identifiants
pubmed: 34757478
doi: 10.1007/s00438-021-01830-w
pii: 10.1007/s00438-021-01830-w
doi:
Substances chimiques
DNA, Mitochondrial
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
47-62Subventions
Organisme : Government of the Russian Federation
ID : 14.W03.31.0016 "Dynamics of Peoples
Organisme : Government of the Russian Federation
ID : Empires in the History of Inner Asia"
Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Références
Andrews RM, Kubacka I, Chinnery PF, Lightowlers RN, Turnbull DM, Howell N (1999) Reanalysis and revision of the Cambridge reference sequence for human mitochondrial DNA. Nat Genet 23(2):147. https://doi.org/10.1038/13779
doi: 10.1038/13779
pubmed: 10508508
Balaresque P, Poulet N, Cussat-Blanc S, Gerard P, Quintana-Murci L, Heyer E, Jobling MA (2015) Y-chromosome descent clusters and male differential reproductive success: young lineage expansions dominate Asian pastoral nomadic populations. Eur J Hum Genet 23(10):1413–1422. https://doi.org/10.1038/ejhg.2014.285
doi: 10.1038/ejhg.2014.285
pubmed: 25585703
pmcid: 4430317
Cardona A, Pagani L, Antao T, Lawson DJ, Eichstaedt CA, Yngvadottir B, Shwe MT, Wee J, Romero IG, Raj S, Metspalu M, Villems R, Willerslev E, Tyler-Smith C, Malyarchuk BA, Derenko MV, Kivisild T (2014) Genome-wide analysis of cold adaptation in indigenous Siberian populations. PLoS ONE 9(5):e98076. https://doi.org/10.1371/journal.pone.0098076
doi: 10.1371/journal.pone.0098076
pubmed: 24847810
pmcid: 4029955
Cox MP (2008) Accuracy of molecular dating with the Rho statistic: Deviations from coalescent expectations under a range of demographic models. Hum Biol 80(4):335–357. https://doi.org/10.3378/1534-6617-80.4.335
Damgaard PB, Marchi N, Rasmussen S, Peyrot M, Renaud G, Korneliussen T, Moreno-Mayar JV, Pedersen MW, Goldberg A, Usmanova E, Baimukhanov N, Loman V, Hedeager L, Pedersen AG, Nielsen K, Afanasiev G, Akmatov K, Aldashev A, Alpaslan A, Baimbetov G, Bazaliiskii VI, Beisenov A, Boldbaatar B, Boldgiv B, Dorzhu C, Ellingvag S, Erdenebaatar D, Dajani R, Dmitriev E, Evdokimov V, Frei KM, Gromov A, Goryachev A, Hakonarson H, Hegay T, Khachatryan Z, Khaskhanov R, Kitov E, Kolbina A, Kubatbek T, Kukushkin A, Kukushkin I, Lau N, Margaryan A, Merkyte I, Mertz IV, Mertz VK, Mijiddorj E, Moiyesev V, Mukhtarova G, Nurmukhanbetov B, Orozbekova Z, Panyushkina I, Pieta K, Smrčka V, Shevnina I, Logvin A, Sjögren KG, Štolcová T, Taravella AM, Tashbaeva K, Tkachev A, Tulegenov T, Voyakin D, Yepiskoposyan L, Undrakhbold S, Varfolomeev V, Weber A, Wilson Sayres MA, Kradin N, Allentoft ME, Orlando L, Nielsen R, Sikora M, Heyer E, Kristiansen K, Willerslev E (2018) 137 ancient human genomes from across the Eurasian steppes. Nature 557(7705):369–374. https://doi.org/10.1038/s41586-018-0094-2
doi: 10.1038/s41586-018-0094-2
pubmed: 29743675
Derenko M, Malyarchuk B, Grzybowski T, Denisova G, Dambueva I, Perkova M, Dorzhu C, Luzina F, Lee HK, Vanecek T, Villems R, Zakharov I (2007) Phylogeographic analysis of mitochondrial DNA in northern Asian populations. Am J Hum Genet 81(5):1025–1041. https://doi.org/10.1086/522933
doi: 10.1086/522933
pubmed: 17924343
pmcid: 2265662
Derenko M, Malyarchuk B, Grzybowski T, Denisova G, Rogalla U, Perkova M, Dambueva I, Zakharov I (2010) Origin and post-glacial dispersal of mitochondrial DNA haplogroups C and D in northern Asia. PLoS ONE 5(12):e15214. https://doi.org/10.1371/journal.pone.0015214
doi: 10.1371/journal.pone.0015214
pubmed: 21203537
pmcid: 3006427
Derenko M, Malyarchuk B, Denisova G, Perkova M, Rogalla U, Grzybowski T, Khusnutdinova E, Dambueva I, Zakharov I (2012) Complete mitochondrial DNA analysis of eastern Eurasian haplogroups rarely found in populations of northern Asia and eastern Europe. PLoS ONE 7(2):e32179. https://doi.org/10.1371/journal.pone.0032179
doi: 10.1371/journal.pone.0032179
pubmed: 22363811
pmcid: 3283723
Derenko M, Malyarchuk B, Denisova G, Perkova M, Litvinov A, Grzybowski T, Dambueva I, Skonieczna K, Rogalla U, Tsybovsky I, Zakharov I (2014) Western Eurasian ancestry in modern Siberians based on mitogenomic data. BMC Evol Biol 14:217. https://doi.org/10.1186/s12862-014-0217-9
doi: 10.1186/s12862-014-0217-9
pubmed: 25301575
pmcid: 4195960
Derenko M, Denisova G, Malyarchuk B, Dambueva I, Bazarov B (2018) Mitogenomic diversity and differentiation of the Buryats. J Hum Genet 63(1):71–81. https://doi.org/10.1038/s10038-017-0370-2
doi: 10.1038/s10038-017-0370-2
pubmed: 29215085
Derenko M, Denisova G, Malyarchuk B, Hovhannisyan A, Khachatryan Z, Hrechdakian P, Litvinov A, Yepiskoposyan L (2019) Insights into matrilineal genetic structure, differentiation and ancestry of Armenians based on complete mitogenome data. Mol Genet Genom 294(6):1547–1559. https://doi.org/10.1007/s00438-019-01596-2
doi: 10.1007/s00438-019-01596-2
Drummond AJ, Rambaut A, Shapiro B, Pybus OG (2005) Bayesian coalescent inference of past population dynamics from molecular sequences. Mol Biol Evol 22(5):1185–1192. https://doi.org/10.1093/molbev/msi103
doi: 10.1093/molbev/msi103
pubmed: 15703244
Duggan AT, Whitten M, Wiebe V, Crawford M, Butthof A, Spitsyn V, Makarov S, Novgorodov I, Osakovsky V, Pakendorf B (2013) Investigating the prehistory of Tungusic peoples of Siberia and the Amur-Ussuri region with complete mtDNA genome sequences and Y-chromosomal markers. PLoS ONE 8(12):e83570. https://doi.org/10.1371/journal.pone.0083570
doi: 10.1371/journal.pone.0083570
pubmed: 24349531
pmcid: 3861515
Excoffier L, Lischer HE (2010) Arlequin suite ver 3.5: a new series of programs to perform population genetics analyses under Linux and Windows. Mol Ecol Resour 10(3):564–567. https://doi.org/10.1111/j.1755-0998.2010.02847.x
doi: 10.1111/j.1755-0998.2010.02847.x
pubmed: 21565059
Forster P, Harding R, Torroni A, Bandelt HJ (1996) Origin and evolution of Native American mtDNA variation: a reappraisal. Am J Hum Genet 59(4):935–945
pubmed: 8808611
pmcid: 1914796
Gomes SM, Bodner M, Souto L, Zimmermann B, Huber G, Strobl C, Röck AW, Achilli A, Olivieri A, Torroni A, Côrte-Real F, Parson W (2015) Human settlement history between Sunda and Sahul: a focus on East Timor (Timor-Leste) and the Pleistocenic mtDNA diversity. BMC Genom 16(1):70. https://doi.org/10.1186/s12864-014-1201-x
doi: 10.1186/s12864-014-1201-x
Heinz T, Pala M, Gymez-Carballa A, Richards MB, Salas A (2017) Updating the African human mitochondrial DNA tree: relevance to forensic and population genetics. Forensic Sci Int Genet 27:156–159. https://doi.org/10.1016/j.fsigen.2016.12.016
doi: 10.1016/j.fsigen.2016.12.016
pubmed: 28086175
Jeong C, Balanovsky O, Lukianova E, Kahbatkyzy N, Flegontov P, Zaporozhchenko V, Immel A, Wang CC, Ixan O, Khussainova E, Bekmanov B, Zaibert V, Lavryashina M, Pocheshkhova E, Yusupov Y, Agdzhoyan A, Koshel S, Bukin A, Nymadawa P, Turdikulova S, Dalimova D, Churnosov M, Skhalyakho R, Daragan D, Bogunov Y, Bogunova A, Shtrunov A, Dubova N, Zhabagin M, Yepiskoposyan L, Churakov V, Pislegin N, Damba L, Saroyants L, Dibirova K, Atramentova L, Utevska O, Idrisov E, Kamenshchikova E, Evseeva I, Metspalu M, Outram AK, Robbeets M, Djansugurova L, Balanovska E, Schiffels S, Haak W, Reich D, Krause J (2019) The genetic history of admixture across inner Eurasia. Nat Ecol Evol 3(6):966–976. https://doi.org/10.1038/s41559-019-0878-2
doi: 10.1038/s41559-019-0878-2
pubmed: 31036896
pmcid: 6542712
Jeong C, Wang K, Wilkin S, Taylor WTT, Miller BK, Bemmann JH, Stahl R, Chiovelli C, Knolle F, Ulziibayar S, Khatanbaatar D, Erdenebaatar D, Erdenebat U, Ochir A, Ankhsanaa G, Vanchigdash C, Ochir B, Munkhbayar C, Tumen D, Kovalev A, Kradin N, Bazarov BA, Miyagashev DA, Konovalov PB, Zhambaltarova E, Miller AV, Haak W, Schiffels S, Krause J, Boivin N, Erdene M, Hendy J, Warinner C (2020) A dynamic 6,000-year genetic history of Eurasia’s Eastern Steppe. Cell 183(4):890-904.e29. https://doi.org/10.1016/j.cell.2020.10.015
doi: 10.1016/j.cell.2020.10.015
pubmed: 33157037
pmcid: 7664836
Kılınç GM, Kashuba N, Yaka R, Sümer AP, Yüncü E, Shergin D, Ivanov GL, Kichigin D, Pestereva K, Volkov D, Mandryka P, Kharinskii A, Tishkin A, Ineshin E, Kovychev E, Stepanov A, Alekseev A, Fedoseeva SA, Somel M, Jakobsson M, Krzewińska M, Storå J, Götherström A (2018) Investigating Holocene human population history in North Asia using ancient mitogenomes. Sci Rep 8(1):8969. https://doi.org/10.1038/s41598-018-27325-0
doi: 10.1038/s41598-018-27325-0
pubmed: 29895902
pmcid: 5997703
Kradin NN, Skrynnikova TD (2006) The Genghis Khan empire. Vostochnaja Literatura, Moscow
Li YC, Tian JY, Liu FW, Yang BY, Gu KSY, Rahman ZU, Yang LQ, Chen FH, Dong GH, KongQP, (2019) Neolithic millet farmers contributed to the permanent settlement of the Tibetan Plateau by adopting barley agriculture. Natl Sci Rev 6:1005–1013. https://doi.org/10.1093/nsr/nwz080
doi: 10.1093/nsr/nwz080
pubmed: 34691962
pmcid: 8291429
Librado P, Rozas J (2009) DnaSP v5: a software for comprehensive analysis of DNA polymorphism data. Bioinformatics 25(11):1451–1452. https://doi.org/10.1093/bioinformatics/btp187
doi: 10.1093/bioinformatics/btp187
pubmed: 19346325
Macaulay V, Soares P, Richards MB (2019) Rectifying long-standing misconceptions about the ρ statistic for molecular dating. PLoS ONE 14(2):e0212311. https://doi.org/10.1371/journal.pone.0212311
doi: 10.1371/journal.pone.0212311
pubmed: 30779770
pmcid: 6380571
Malyarchuk B, Grzybowski T, Derenko M, Perkova M, Vanecek T, Lazur J, Gomolcak P, Tsybovsky I (2008) Mitochondrial DNA phylogeny in Eastern and Western Slavs. Mol Biol Evol 25(8):1651–1658. https://doi.org/10.1093/molbev/msn114
doi: 10.1093/molbev/msn114
pubmed: 18477584
Malyarchuk B, Derenko M, Denisova G, Wozniak M, Grzybowski T, Dambueva I, Zakharov I (2010a) Phylogeography of the Y-chromosome haplogroup C in northern Eurasia. Ann Hum Genet 74(6):539–546. https://doi.org/10.1111/j.1469-1809.2010.00601
doi: 10.1111/j.1469-1809.2010.00601
pubmed: 20726964
Malyarchuk B, Derenko M, Grzybowski T, Perkova M, Rogalla U, Vanecek T, Tsybovsky I (2010b) The peopling of Europe from the mitochondrial haplogroup U5 perspective. PLoS ONE 5(4):e10285. https://doi.org/10.1371/journal.pone.0010285
doi: 10.1371/journal.pone.0010285
pubmed: 20422015
pmcid: 2858207
Malyarchuk BA, Derenko M, Denisova G, Woźniak M, Rogalla U, Dambueva I, Grzybowski T (2016) Y chromosome haplotype diversity in Mongolic-speaking populations and gene conversion at the duplicated STR DYS385a, b in haplogroup C3–M407. J Hum Genet 61(6):491–496. https://doi.org/10.1038/jhg.2016.14
doi: 10.1038/jhg.2016.14
pubmed: 26911356
Olivieri A, Pala M, Gandini F, Hooshiar Kashani B, Perego UA, Woodward SR, Grugni V, Battaglia V, Semino O, Achilli A, Richards MB, Torroni A (2013) Mitogenomes from two uncommon haplogroups mark late glacial/postglacial expansions from the Near East and Neolithic dispersals within Europe. PLoS ONE 8(7):e70492. https://doi.org/10.1371/journal.pone.0070492
doi: 10.1371/journal.pone.0070492
pubmed: 23936216
pmcid: 3729697
Olivieri A, Sidore C, Achilli A, Angius A, Posth C, Furtwängler A, Brandini S, Capodiferro MR, Gandini F, Zoledziewska M, Pitzalis M, Maschio A, Busonero F, Lai L, Skeates R, Gradoli MG, Beckett J, Marongiu M, Mazzarello V, Marongiu P, Rubino S, Rito T, Macaulay V, Semino O, Pala M, Abecasis GR, Schlessinger D, Conde-Sousa E, Soares P, Richards MB, Cucca F, Torroni A (2017) Mitogenome diversity in Sardinians: a genetic window onto an island’s past. Mol Biol Evol 34(5):1230–1239. https://doi.org/10.1093/molbev/msx120
doi: 10.1093/molbev/msx120
pubmed: 28177087
pmcid: 5400395
Översti S, Onkamo P, Stoljarova M, Budowle B, Sajantila A, Palo JU (2017) Identification and analysis of mtDNA genomes attributed to Finns reveal long-stagnant demographic trends obscured in the total diversity. Sci Rep 7(1):6193. https://doi.org/10.1038/s41598-017-05673-7
doi: 10.1038/s41598-017-05673-7
pubmed: 28733587
pmcid: 5522469
Palanichamy MG, Mitra B, Zhang CL, Debnath M, Li GM, Wang HW, Agrawal S, Chaudhuri TK, Zhang YP (2015) West Eurasian mtDNA lineages in India: an insight into the spread of the Dravidian language and the origins of the caste system. Hum Genet 134(6):637–647. https://doi.org/10.1007/s00439-015-1547-4
doi: 10.1007/s00439-015-1547-4
pubmed: 25832481
Pankratov V, Litvinov S, Kassian A, Shulhin D, Tchebotarev L, Yunusbayev B, Möls M, Sahakyan H, Yepiskoposyan L, Rootsi S, Metspalu E, Golubenko M, Ekomasova N, Akhatova F, Khusnutdinova E, Heyer E, Endicott P, Derenko M, Malyarchuk B, Metspalu M, Davydenko O, Villems R, Kushniarevich A (2016) East Eurasian ancestry in the middle of Europe: genetic footprints of Steppe nomads in the genomes of Belarusian Lipka Tatars. Sci Rep 6:30197. https://doi.org/10.1038/srep30197
doi: 10.1038/srep30197
pubmed: 27453128
pmcid: 4958967
Pugach I, Matveev R, Spitsyn V, Makarov S, Novgorodov I, Osakovsky V, Stoneking M, Pakendorf B (2016) The complex admixture history and recent southern origins of Siberian populations. Mol Biol Evol 33(7):1777–1795. https://doi.org/10.1093/molbev/msw055
doi: 10.1093/molbev/msw055
pubmed: 26993256
pmcid: 4915357
Raymond M, Rousset F (1995) An exact test for population differentiation. Evolution 49(6):1280–1283. https://doi.org/10.1111/j.1558-5646.1995.tb04456.x
doi: 10.1111/j.1558-5646.1995.tb04456.x
pubmed: 28568523
Saillard J, Forster P, Lynnerup N, Bandelt HJ, Norby S (2000) mtDNA variation among Greenland Eskimos: the edge of the Beringian expansion. Am J Hum Genet 67(3):718–726. https://doi.org/10.1086/303038
doi: 10.1086/303038
pubmed: 10924403
pmcid: 1287530
Sikora M, Pitulko VV, Sousa VC, Allentoft ME, Vinner L, Rasmussen S, Margaryan A, de Barros DP, de la Fuente C, Renaud G, Yang MA, Fu Q, Dupanloup I, Giampoudakis K, Nogués-Bravo D, Rahbek C, Kroonen G, Peyrot M, McColl H, Vasilyev SV, Veselovskaya E, Gerasimova M, Pavlova EY, Chasnyk VG, Nikolskiy PA, Gromov AV, Khartanovich VI, Moiseyev V, Grebenyuk PS, Fedorchenko AY, Lebedintsev AI, Slobodin SB, Malyarchuk BA, Martiniano R, Meldgaard M, Arppe L, Palo JU, Sundell T, Mannermaa K, Putkonen M, Alexandersen V, Primeau C, Baimukhanov N, Malhi RS, Sjögren KG, Kristiansen K, Wessman A, Sajantila A, Lahr MM, Durbin R, Nielsen R, Meltzer DJ, Excoffier L, Willerslev E (2019) The population history of northeastern Siberia since the Pleistocene. Nature 570(7760):182–188. https://doi.org/10.1038/s41586-019-1279-z
doi: 10.1038/s41586-019-1279-z
pubmed: 31168093
Silva M, Oliveira M, Vieira D, Brandão A, Rito T, Pereira JB, Fraser RM, Hudson B, Gandini F, Edwards C, Pala M, Koch J, Wilson JF, Pereira L, Richards MB, Soares PA (2017) Genetic chronology for the Indian Subcontinent points to heavily sex-biased dispersals. BMC Evol Biol 17(1):88. https://doi.org/10.1186/s12862-017-0936-9
doi: 10.1186/s12862-017-0936-9
pubmed: 28335724
pmcid: 5364613
Siska V, Jones ER, Jeon S, Bhak Y, Kim HM, Cho YS, Kim H, Lee K, Veselovskaya E, Balueva T, Gallego-Llorente M, Hofreiter M, Bradley DG, Eriksson A, Pinhasi R, Bhak J, Manica A (2017) Genome-wide data from two early Neolithic East Asian individuals dating to 7700 years ago. Sci Adv 3(2):e10601877. https://doi.org/10.1126/sciadv.1601877
doi: 10.1126/sciadv.1601877
Soares P, Ermini L, Thomson N, Mormina M, Rito T, Rohl A, Salas A, Oppenheimer S, Macaulay V, Richards MB (2009) Correcting for purifying selection: an improved human mitochondrial molecular clock. Am J Hum Genet 84(6):740–759. https://doi.org/10.1016/j.ajhg.2009.05.001
doi: 10.1016/j.ajhg.2009.05.001
pubmed: 19500773
pmcid: 2694979
Soares P, Alshamali F, Pereira JB, Fernandes V, Silva NM, Afonso C, Costa MD, Musilová E, Macaulay V, Richards MB, Cerny V, Pereira L (2012) The expansion of mtDNA haplogroup L3 within and out of Africa. Mol Biol Evol 29(3):915–927. https://doi.org/10.1093/molbev/msr245
doi: 10.1093/molbev/msr245
pubmed: 22096215
Soares PA, Trejaut JA, Rito T, Cavadas B, Hill C, Eng KK, Mormina M, Brandão A, Fraser RM, Wang TY, Loo JH, Snell C, Ko TM, Amorim A, Pala M, Macaulay V, Bulbeck D, Wilson JF, Gusmão L, Pereira L, Oppenheimer S, Lin M, Richards MB (2016) Resolving the ancestry of Austronesian-speaking populations. Hum Genet 135(3):309–326. https://doi.org/10.1007/s00439-015-1620-z
doi: 10.1007/s00439-015-1620-z
pubmed: 26781090
pmcid: 4757630
Suchard MA, Lemey P, Baele G, Ayres DL, Drummond AJ, Rambaut A (2018) Bayesian phylogenetic and phylodynamic data integration using BEAST 1.10. Virus Evol 4:16. https://doi.org/10.1093/ve/vey016
doi: 10.1093/ve/vey016
Sukernik RI, Volodko NV, Mazunin IO, Eltsov NP, Dryomov SV, Starikovskaya EB (2012) Mitochondrial genome diversity in the Tubalar, Even, and Ulchi: contribution to prehistory of native Siberians and their affinities to Native Americans. Am J Phys Anthropol 1:123–138. https://doi.org/10.1002/ajpa.22050
doi: 10.1002/ajpa.22050
Torroni A, Rengo C, Guida V, Cruciani F, Sellitto D, Coppa A, Calderon FL, Simionati B, Valle G, Richards M, Macaulay V, Scozzari R (2001) Do the four clades of the mtDNA haplogroup L2 evolve at different rates? Am J Hum Genet 69(6):1348–1356. https://doi.org/10.1086/324511
doi: 10.1086/324511
pubmed: 11595973
pmcid: 1235545
van Oven M, Kayser M (2009) Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation. Hum Mutat 30(2):E386-394. https://doi.org/10.1002/humu.20921
doi: 10.1002/humu.20921
pubmed: 18853457
Xue Y, Zerjal T, Bao W, Zhu S, Lim SK, Shu Q, Xu J, Du R, Fu S, Li P, Yang H, Tyler-Smith C (2005) Recent spread of a Y-chromosomal lineage in northern China and Mongolia. Am J Hum Genet 77(6):1112–1116. https://doi.org/10.1086/498583
doi: 10.1086/498583
pubmed: 16380921
pmcid: 1285168
Yu H, Spyrou MA, Karapetian M, Shnaider S, Radzevičiūtė R, Nägele K, Neumann GU, Penske S, Zech J, Lucas M, LeRoux P, Roberts P, Pavlenok G, Buzhilova A, Posth C, Jeong C, Krause J (2020) Paleolithic to Bronze Age Siberians reveal connections with first Americans and across Eurasia. Cell 181(6):1232–1245. https://doi.org/10.1016/j.cell.2020.04.037
doi: 10.1016/j.cell.2020.04.037
pubmed: 32437661
Yunusbayev B, Metspalu M, Metspalu E, Valeev A, Litvinov S, Valiev R, Akhmetova V, Balanovska E, Balanovsky O, Turdikulova S, Dalimova D, Nymadawa P, Bahmanimehr A, Sahakyan H, Tambets K, Fedorova S, Barashkov N, Khidiyatova I, Mihailov E, Khusainova R, Damba L, Derenko M, Malyarchuk B, Osipova L, Voevoda M, Yepiskoposyan L, Kivisild T, Khusnutdinova E, Villems R (2015) The genetic legacy of the expansion of Turkic-speaking nomads across Eurasia. PLoS Genet 11(4):e1005068. https://doi.org/10.1371/journal.pgen.1005068
doi: 10.1371/journal.pgen.1005068
pubmed: 25898006
pmcid: 4405460
Zerjal T, Xue Y, Bertorelle G, Wells RS, Bao W, Zhu S, Qamar R, Ayub Q, Mohyuddin A, Fu S, Li P, Yuldasheva N, Ruzibakiev R, Xu J, Shu Q, Du R, Yang H, Hurles ME, Robinson E, Gerelsaikhan T, Dashnyam B, Mehdi SQ, Tyler-Smith C (2003) The genetic legacy of the Mongols. Am J Hum Genet 72(3):717–721. https://doi.org/10.1086/367774
doi: 10.1086/367774
pubmed: 12592608
pmcid: 1180246
Zheng HX, Yan S, Qin ZD, Wang Y, Tan JZ, Li H, Jin L (2011) Major population expansion of East Asians began before neolithic time: evidence of mtDNA genomes. PLoS ONE 6(10):e25835. https://doi.org/10.1371/journal.pone.0025835
doi: 10.1371/journal.pone.0025835
pubmed: 21998705
pmcid: 3188578
Zheng HX, Li L, Jiang XY, Yan S, Qin Z, Wang X, Jin L (2017) MtDNA genomes reveal a relaxation of selective constraints in low-BMI individuals in a Uyghur population. Hum Genet 136(10):1353–1362. https://doi.org/10.1007/s00439-017-1829-0
doi: 10.1007/s00439-017-1829-0
pubmed: 28799012