sLRP1'in up retinol keeps the gut SAAfe.

Carrier Proteins Tretinoin / metabolism Vitamin A / metabolism

Journal

Immunity
ISSN: 1097-4180
Titre abrégé: Immunity
Pays: United States
ID NLM: 9432918

Informations de publication

Date de publication:
09 11 2021
Historique:
entrez: 10 11 2021
pubmed: 11 11 2021
medline: 26 11 2021
Statut: ppublish

Résumé

Retinol is shuttled to myeloid cells for conversion to retinoic acid, but the receptor facilitating uptake of SAA:retinol complexes on myeloid cells is unknown. In a recent issue of Science, Bang et al. (2021) use genetic and biochemical approaches to reveal this critical receptor to be LRP1 and show that this axis is essential for intestinal innate and adaptive immune responses.

Identifiants

DOI: 10.1016/j.immuni.2021.10.013 PMID: 34758336
pubmed: 34758336
pii: S1074-7613(21)00450-7
doi: 10.1016/j.immuni.2021.10.013
pii:
doi:

Substances chimiques

Carrier Proteins 0
Vitamin A 11103-57-4
Tretinoin 5688UTC01R

Types de publication

Journal Article Comment

Langues

eng

Sous-ensembles de citation

IM

Pagination

2447-2449

Commentaires et corrections

Type : CommentOn

Informations de copyright

Copyright © 2021 Elsevier Inc. All rights reserved.

Auteurs

Jasmine Labuda (J)

Center for Fundamental Immunology, Benaroya Research Institute, 1201 9(th) Ave., Seattle, WA 98101, USA.

Oliver J Harrison (OJ)

Center for Fundamental Immunology, Benaroya Research Institute, 1201 9(th) Ave., Seattle, WA 98101, USA; Department of Immunology, University of Washington, 750 Republican St., Seattle, WA 98108, USA. Electronic address: oharrison@benaroyaresearch.org.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de transport › sLRP1'in up retinol keeps the gut SAAfe.
questionsmedicales.fr › Facteurs biologiques › Pigments biologiques › Caroténoïdes › Rétinoïdes › Trétinoïne › sLRP1'in up retinol keeps the gut SAAfe.
questionsmedicales.fr › Facteurs biologiques › Pigments biologiques › Caroténoïdes › Rétinoïdes › Rétinol › sLRP1'in up retinol keeps the gut SAAfe.