Global and Regional White Matter Fractional Anisotropy in Children with Chronic Kidney Disease.
brain
chronic kidney disease
cognition
pediatric
white matter
Journal
The Journal of pediatrics
ISSN: 1097-6833
Titre abrégé: J Pediatr
Pays: United States
ID NLM: 0375410
Informations de publication
Date de publication:
03 2022
03 2022
Historique:
received:
02
07
2021
revised:
29
10
2021
accepted:
02
11
2021
pubmed:
11
11
2021
medline:
29
4
2022
entrez:
10
11
2021
Statut:
ppublish
Résumé
To investigate the associations between neurocognition and white matter integrity in children with chronic kidney disease (CKD). This cross-sectional study included 17 boys (age 6-16 years) with a diagnosis of mild to moderate (stages 1-3, nondialysis/nontransplant) CKD because of congenital anomalies of the kidney and urinary tract and 20 typically developing community controls. Participants underwent 3T neuroimaging and diffusion-weighted magnetic resonance imaging to assess white matter fractional anisotropy. Multivariable linear regression models were used to evaluate the impact of each group (controls vs CKD) on white matter fractional anisotropy, adjusting for age. Associations between white matter fractional anisotropy and neurocognitive abilities within the CKD group were also evaluated using regression models that were adjusted for age. The false discovery rate was used to account for multiple comparisons; wherein false discovery values <0.10 were considered significant. Global white matter fractional anisotropy was reduced in patients with CKD relative to controls (standardized estimate = -0.38, 95% CI -0.69:-0.07), driven by reductions within the body of the corpus callosum (standardized estimate = -0.44, 95% CI -0.75:-0.13), cerebral peduncle (SE = -0.37, 95% CI -0.67:-0.07), cingulum (hippocampus) (standardized estimate = -0.45, 95% CI -0.75:-0.14), and posterior limb of the internal capsule (standardized estimate = -0.46, 95% CI -0.76:-0.15). Medical variables and neurocognitive abilities were not significantly associated with white matter fractional anisotropy. White matter development is vulnerable in children with CKD because of congenital causes, even prior to the need for dialysis or transplantation.
Identifiants
pubmed: 34758354
pii: S0022-3476(21)01071-4
doi: 10.1016/j.jpeds.2021.11.006
pmc: PMC8882141
mid: NIHMS1756728
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
166-173.e3Subventions
Organisme : NIDCR NIH HHS
ID : K23 DE024511
Pays : United States
Organisme : NIDDK NIH HHS
ID : K23 DK110443
Pays : United States
Organisme : NICHD NIH HHS
ID : P50 HD103556
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK128835
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
Références
Cereb Cortex. 2005 Dec;15(12):1848-54
pubmed: 15758200
Pediatr Nephrol. 2007 Dec;22(12):1999-2009
pubmed: 17310363
BMC Nephrol. 2017 Jul 5;18(1):213
pubmed: 28676035
Neuroimage. 2003 Oct;20(2):870-88
pubmed: 14568458
J Pathol Transl Med. 2017 Sep;51(5):449-455
pubmed: 28797157
Philos Trans R Soc Lond B Biol Sci. 2006 Sep 29;361(1473):1531-44
pubmed: 16939973
PLoS One. 2019 Apr 30;14(4):e0215942
pubmed: 31039171
PLoS One. 2012;7(6):e38272
pubmed: 22701619
Pediatr Res. 2018 Sep;84(3):387-392
pubmed: 29967532
Psychol Bull. 1992 Jul;112(1):155-9
pubmed: 19565683
Neuroimage. 2008 Apr 1;40(2):570-582
pubmed: 18255316
Neurology. 2016 Mar 29;86(13):1208-16
pubmed: 26920359
Kidney Int. 2021 Apr;99(4):948-956
pubmed: 33301749
PLoS One. 2016 May 26;11(5):e0155902
pubmed: 27227649
Front Integr Neurosci. 2013 Mar 11;7:9
pubmed: 23483798
Clin J Am Soc Nephrol. 2011 Aug;6(8):1824-30
pubmed: 21737850
Biostatistics. 2007 Jan;8(1):118-27
pubmed: 16632515
Am J Kidney Dis. 2016 Apr;67(4):567-75
pubmed: 26476795
Clin J Am Soc Nephrol. 2013 Aug;8(8):1429-48
pubmed: 23723341
Pediatr Res. 2016 Aug;80(2):197-203
pubmed: 27064239
Neuroimage. 2018 Feb 15;167:104-120
pubmed: 29155184
Stroke. 2008 Jan;39(1):55-61
pubmed: 18048865
J Neurosci. 2001 Feb 15;21(4):1302-12
pubmed: 11160401
Pediatr Radiol. 2013 Jan;43(1):60-8
pubmed: 23288478
Biophys J. 2005 Nov;89(5):2927-38
pubmed: 16100258
J Am Soc Nephrol. 2017 Aug;28(8):2303-2309
pubmed: 28348065
Pediatr Res. 2021 Feb;89(3):526-532
pubmed: 33069166
Neuroimage. 2019 Aug 1;196:49-58
pubmed: 30959194
Brain Behav. 2016 Dec 29;7(2):e00621
pubmed: 28239531
BMJ. 2019 May 1;365:l1346
pubmed: 31043374
Neuroimage. 2007 Jul 15;36(4):1065-73
pubmed: 17513132
Pediatr Nephrol. 2012 Mar;27(3):363-73
pubmed: 21713524
Brain Res Bull. 2001 Feb;54(3):255-66
pubmed: 11287130
Stroke. 1997 Mar;28(3):652-9
pubmed: 9056627
Ment Retard Dev Disabil Res Rev. 2006;12(3):208-15
pubmed: 17061289
Neuroimage Clin. 2020;28:102428
pubmed: 32980598
Am J Kidney Dis. 2018 Sep;72(3):349-359
pubmed: 29398180
Neuroimage. 2011 Feb 1;54(3):2033-44
pubmed: 20851191
Radiology. 1996 Dec;201(3):637-48
pubmed: 8939209
Pediatr Nephrol. 2020 Dec;35(12):2221-2229
pubmed: 31897717
Neuroimage. 2016 Jan 15;125:1063-1078
pubmed: 26481672
Kidney Int. 2012 Aug;82(4):445-53
pubmed: 22622496
Pediatrics. 2018 May;141(5):
pubmed: 29666163
Magn Reson Med. 1996 Dec;36(6):893-906
pubmed: 8946355
Neurology. 2015 Jul 14;85(2):154-61
pubmed: 26085601