VMAT2 availability in Parkinson's disease with probable REM sleep behaviour disorder.

Corpus Striatum / metabolism Dopamine Plasma Membrane Transport Proteins / metabolism Humans Parkinson Disease / metabolism REM Sleep Behavior Disorder / complications Vesicular Monoamine Transport Proteins / metabolism
Parkinson’s disease Positron emission tomography REM sleep behaviour disorder VMAT2 [11C]DTBZ

Journal

Molecular brain
ISSN: 1756-6606
Titre abrégé: Mol Brain
Pays: England
ID NLM: 101468876

Informations de publication

Date de publication:
10 11 2021
Historique:
received: 16 09 2021
accepted: 29 10 2021
entrez: 11 11 2021
pubmed: 12 11 2021
medline: 5 4 2022
Statut: epublish

Résumé

REM sleep behaviour disorder (RBD) can be an early non-motor symptom of Parkinson's disease (PD) with pathology involving mainly the pontine nuclei. Beyond the brainstem, it is unclear if RBD patients comorbid with PD have more affected striatal dopamine denervation compared to PD patients unaffected by RBD (PD-RBD-). To elucidate this, we evaluated the availability of vesicular monoamine transporter 2 (VMAT2), an index of nigrostriatal dopamine innervation, in 15 PD patients with probable RBD (PD-RBD+), 15 PD-RBD-, and 15 age-matched healthy controls (HC) using [

Identifiants

DOI: 10.1186/s13041-021-00875-7 PMID: 34758845 PMC: PMC8579554
pubmed: 34758845
doi: 10.1186/s13041-021-00875-7
pii: 10.1186/s13041-021-00875-7
pmc: PMC8579554
doi:

Substances chimiques

Dopamine Plasma Membrane Transport Proteins 0
SLC18A2 protein, human 0
Vesicular Monoamine Transport Proteins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

165

Subventions

Organisme : CIHR
ID : MOP 136778
Pays : Canada

Informations de copyright

© 2021. The Author(s).

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Auteurs

Mikaeel Valli (M)

Brain Health Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada. mikaeel.valli@mail.utoronto.ca.
Division of Brain, Imaging and Behaviour - Systems Neuroscience, Krembil Brain Institute, UHN, University of Toronto, Toronto, ON, Canada. mikaeel.valli@mail.utoronto.ca.
Institute of Medical Science, University of Toronto, Toronto, ON, Canada. mikaeel.valli@mail.utoronto.ca.
ORCID: 0000-0002-4059-2333

Sang Soo Cho (SS)

Department of Brain and Cognitive Science, Seoul National University, Seoul, Republic of Korea.

Carme Uribe (C)

Brain Health Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada.

Mario Masellis (M)

Institute of Medical Science, University of Toronto, Toronto, ON, Canada.
Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, ON, Canada.
Division of Neurology, Department of Medicine, University of Toronto, Toronto, ON, Canada.

Robert Chen (R)

Division of Brain, Imaging and Behaviour - Systems Neuroscience, Krembil Brain Institute, UHN, University of Toronto, Toronto, ON, Canada.
Institute of Medical Science, University of Toronto, Toronto, ON, Canada.
Edmond J. Safra Parkinson Disease Program & Morton and Gloria Shulman Movement Disorder Unit, Neurology Division, Dept. of Medicine, Toronto Western Hospital, UHN, University of Toronto, Toronto, ON, Canada.

Alexander Mihaescu (A)

Brain Health Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada.
Division of Brain, Imaging and Behaviour - Systems Neuroscience, Krembil Brain Institute, UHN, University of Toronto, Toronto, ON, Canada.
Institute of Medical Science, University of Toronto, Toronto, ON, Canada.

Antonio P Strafella (AP)

Brain Health Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada. antonio.strafella@uhn.ca.
Division of Brain, Imaging and Behaviour - Systems Neuroscience, Krembil Brain Institute, UHN, University of Toronto, Toronto, ON, Canada. antonio.strafella@uhn.ca.
Institute of Medical Science, University of Toronto, Toronto, ON, Canada. antonio.strafella@uhn.ca.
Edmond J. Safra Parkinson Disease Program & Morton and Gloria Shulman Movement Disorder Unit, Neurology Division, Dept. of Medicine, Toronto Western Hospital, UHN, University of Toronto, Toronto, ON, Canada. antonio.strafella@uhn.ca.

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Classifications MeSH

questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Noyaux gris centraux › Corps strié › VMAT2 availability in Parkinson's disease with...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Protéines transporteurs de solutés › Transporteurs de la dopamine › VMAT2 availability in Parkinson's disease with...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › VMAT2 availability in Parkinson's disease with...
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › Maladie de Parkinson › VMAT2 availability in Parkinson's disease with...
questionsmedicales.fr › Troubles mentaux › Troubles de la veille et du sommeil › Parasomnies › Parasomnies du sommeil paradoxal › Trouble du comportement en sommeil paradoxal › VMAT2 availability in Parkinson's disease with...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Transporteurs de neurotransmetteurs › Transporteurs vésiculaires des neurotransmetteurs › Transporteurs vésiculaires des amines biogènes › Transporteurs vésiculaires des monoamines › VMAT2 availability in Parkinson's disease with...