Molecular evolution and genomic characteristics of genotype H1 of measles virus.


Journal

Journal of medical virology
ISSN: 1096-9071
Titre abrégé: J Med Virol
Pays: United States
ID NLM: 7705876

Informations de publication

Date de publication:
02 2022
Historique:
revised: 25 10 2021
received: 14 09 2021
accepted: 09 11 2021
pubmed: 12 11 2021
medline: 18 12 2021
entrez: 11 11 2021
Statut: ppublish

Résumé

Measles is one of the most infectious diseases of humans. It is caused by the measles virus (MeV) and can lead to serious illness, lifelong complications, and even death. Whole-genome sequencing (WGS) is now available to study molecular epidemiology and identify MeV transmission pathways. In the present study, WGS of 23 MeV strains of genotype H1, collected in Mainland China between 2006 and 2018, were generated and compared to 31 WGSs from the public domain to analyze genomic characteristics, evolutionary rates and date of emergence of H1 genotype. The noncoding region between M and F protein genes (M/F NCR) was the most variable region throughout the genome. Although the nucleotide substitution rate of H1 WGS was around 0.75 × 10

Identifiants

pubmed: 34761827
doi: 10.1002/jmv.27448
doi:

Substances chimiques

RNA, Viral 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

521-530

Subventions

Organisme : Key Technologies R&D Program of the National Ministry of Science
ID : 2017ZX10104001-002
Organisme : Key Technologies R&D Program of the National Ministry of Science
ID : 2018ZX10713002
Organisme : Key Technologies R&D Program of the National Ministry of Science
ID : 2018ZX10201002-006

Informations de copyright

© 2021 Wiley Periodicals LLC.

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Auteurs

Jinhua Song (J)

National Health Commission (NHC) Key Laboratory of Medical Virology and Viral Diseases. National Institute for Viral Disease Control and Prevention, China CDC;, WHO WPRO Regional Reference Measles/Rubella Laboratory, Beijing, China.

Chongshan Li (C)

Shanghai Municipal Center for Disease Control and Prevention, Shanghai.

Pierre Rivailler (P)

National Health Commission (NHC) Key Laboratory of Medical Virology and Viral Diseases. National Institute for Viral Disease Control and Prevention, China CDC;, WHO WPRO Regional Reference Measles/Rubella Laboratory, Beijing, China.

Huiling Wang (H)

National Health Commission (NHC) Key Laboratory of Medical Virology and Viral Diseases. National Institute for Viral Disease Control and Prevention, China CDC;, WHO WPRO Regional Reference Measles/Rubella Laboratory, Beijing, China.

Manli Hu (M)

National Health Commission (NHC) Key Laboratory of Medical Virology and Viral Diseases. National Institute for Viral Disease Control and Prevention, China CDC;, WHO WPRO Regional Reference Measles/Rubella Laboratory, Beijing, China.
Department of Public Health Laboratory Sciences, School of Public Health, Changsha Medical University, Changsha, Hunan, China.

Zhen Zhu (Z)

National Health Commission (NHC) Key Laboratory of Medical Virology and Viral Diseases. National Institute for Viral Disease Control and Prevention, China CDC;, WHO WPRO Regional Reference Measles/Rubella Laboratory, Beijing, China.

Aili Cui (A)

National Health Commission (NHC) Key Laboratory of Medical Virology and Viral Diseases. National Institute for Viral Disease Control and Prevention, China CDC;, WHO WPRO Regional Reference Measles/Rubella Laboratory, Beijing, China.

Naiying Mao (N)

National Health Commission (NHC) Key Laboratory of Medical Virology and Viral Diseases. National Institute for Viral Disease Control and Prevention, China CDC;, WHO WPRO Regional Reference Measles/Rubella Laboratory, Beijing, China.

Wenbo Xu (W)

National Health Commission (NHC) Key Laboratory of Medical Virology and Viral Diseases. National Institute for Viral Disease Control and Prevention, China CDC;, WHO WPRO Regional Reference Measles/Rubella Laboratory, Beijing, China.
Center for Biosafety Mega-Science, Chinese Academy of Sciences, Beijing, China.

Yan Zhang (Y)

National Health Commission (NHC) Key Laboratory of Medical Virology and Viral Diseases. National Institute for Viral Disease Control and Prevention, China CDC;, WHO WPRO Regional Reference Measles/Rubella Laboratory, Beijing, China.
Center for Biosafety Mega-Science, Chinese Academy of Sciences, Beijing, China.

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