Deaths in children and young people in England after SARS-CoV-2 infection during the first pandemic year.
Adolescent
Age Distribution
Asian People
/ statistics & numerical data
Black People
/ statistics & numerical data
COVID-19
/ complications
Cause of Death
Child
Child, Preschool
England
/ epidemiology
Ethnicity
/ statistics & numerical data
Female
Humans
Infant
Infant, Newborn
Male
SARS-CoV-2
Systemic Inflammatory Response Syndrome
/ epidemiology
White People
/ statistics & numerical data
Journal
Nature medicine
ISSN: 1546-170X
Titre abrégé: Nat Med
Pays: United States
ID NLM: 9502015
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
received:
20
07
2021
accepted:
13
10
2021
pubmed:
13
11
2021
medline:
4
2
2022
entrez:
12
11
2021
Statut:
ppublish
Résumé
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is rarely fatal in children and young people (CYP, <18 years old), but quantifying the risk of death is challenging because CYP are often infected with SARS-CoV-2 exhibiting no or minimal symptoms. To distinguish between CYP who died as a result of SARS-CoV-2 infection and those who died of another cause but were coincidentally infected with the virus, we undertook a clinical review of all CYP deaths with a positive SARS-CoV-2 test from March 2020 to February 2021. The predominant SARS-CoV-2 variants were wild-type and Alpha. Here we show that, of 12,023,568 CYP living in England, 3,105 died, including 61 who were positive for SARS-CoV-2. Of these deaths, 25 were due to SARS-CoV-2 infection (mortality rate, two per million), including 22 due to coronavirus disease 2019-the clinical disease associated with SARS-CoV-2 infection-and 3 were due to pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2. In total, 99.995% of CYP with a positive SARS-CoV-2 test survived. CYP older than 10 years, Asian and Black ethnic backgrounds and comorbidities were over-represented in SARS-CoV-2-related deaths compared with other CYP deaths. These results are important for guiding decisions on shielding and vaccinating children. New variants might have different mortality risks and should be evaluated in a similar way.
Identifiants
pubmed: 34764489
doi: 10.1038/s41591-021-01578-1
pii: 10.1038/s41591-021-01578-1
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
185-192Subventions
Organisme : Kidney Research UK
ID : TF_010_20171124
Organisme : RCUK | Medical Research Council (MRC)
ID : MR/R00160X/1
Organisme : DH | National Institute for Health Research (NIHR)
ID : NIHR202322
Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer Nature America, Inc.
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