Highly immunogenic cancer cells require activation of the WNT pathway for immunological escape.

Animals CD8-Positive T-Lymphocytes / immunology Carcinoma, Non-Small-Cell Lung / genetics Female Humans Lung Neoplasms / genetics Mice Mice, Inbred BALB C Mice, Nude Tumor Escape / immunology Tumor Microenvironment / immunology Wnt Signaling Pathway / immunology

Journal

Science immunology
ISSN: 2470-9468
Titre abrégé: Sci Immunol
Pays: United States
ID NLM: 101688624

Informations de publication

Date de publication:
12 Nov 2021
Historique:
entrez: 12 11 2021
pubmed: 13 11 2021
medline: 8 3 2022
Statut: ppublish

Résumé

PD-1 blockade exerts antitumor effects by reinvigorating tumor antigen–specific CD8

Identifiants

DOI: 10.1126/sciimmunol.abc6424 PMID: 34767457
pubmed: 34767457
doi: 10.1126/sciimmunol.abc6424
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

eabc6424

Auteurs

Yoshiko Takeuchi (Y)

Division of Cancer Immunology, Research Institute/Exploratory Oncology Research & Clinical Trial Center (EPOC), National Cancer Center, Tokyo/Chiba, Japan.
Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Osaka, Japan.
ORCID: 0000-0002-2637-7696

Tokiyoshi Tanegashima (T)

Division of Cancer Immunology, Research Institute/Exploratory Oncology Research & Clinical Trial Center (EPOC), National Cancer Center, Tokyo/Chiba, Japan.
Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
ORCID: 0000-0002-1631-4720

Eiichi Sato (E)

Department of Pathology, Institute of Medical Science, Tokyo Medical University, Tokyo, Japan.

Takuma Irie (T)

Division of Cancer Immunology, Research Institute/Exploratory Oncology Research & Clinical Trial Center (EPOC), National Cancer Center, Tokyo/Chiba, Japan.

Atsuo Sai (A)

Division of Cancer Immunology, Research Institute/Exploratory Oncology Research & Clinical Trial Center (EPOC), National Cancer Center, Tokyo/Chiba, Japan.

Kota Itahashi (K)

Division of Cancer Immunology, Research Institute/Exploratory Oncology Research & Clinical Trial Center (EPOC), National Cancer Center, Tokyo/Chiba, Japan.
ORCID: 0000-0002-1676-8466

Shogo Kumagai (S)

Division of Cancer Immunology, Research Institute/Exploratory Oncology Research & Clinical Trial Center (EPOC), National Cancer Center, Tokyo/Chiba, Japan.
Department of Immunology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Yasuko Tada (Y)

Division of Cancer Immunology, Research Institute/Exploratory Oncology Research & Clinical Trial Center (EPOC), National Cancer Center, Tokyo/Chiba, Japan.
ORCID: 0000-0001-6033-9856

Yosuke Togashi (Y)

Division of Cancer Immunology, Research Institute/Exploratory Oncology Research & Clinical Trial Center (EPOC), National Cancer Center, Tokyo/Chiba, Japan.
ORCID: 0000-0001-9910-0164

Shohei Koyama (S)

Division of Cancer Immunology, Research Institute/Exploratory Oncology Research & Clinical Trial Center (EPOC), National Cancer Center, Tokyo/Chiba, Japan.
Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Osaka, Japan.
ORCID: 0000-0002-6897-9417

Esra A Akbay (EA)

Department of Pathology, University of Texas Southwestern Medical Center, Dallas TX, USA.
ORCID: 0000-0002-4149-2529

Takahiro Karasaki (T)

Department of Immunotherapeutics, University of Tokyo Hospital, Tokyo, Japan.

Keisuke Kataoka (K)

Division of Molecular Oncology, Research Institute, National Cancer Center, Tokyo, Japan.
Department of Pathology and Tumor Biology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
ORCID: 0000-0002-8263-9902

Soichiro Funaki (S)

Department of General Thoracic Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.
ORCID: 0000-0003-2386-4736

Yasushi Shintani (Y)

Department of General Thoracic Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.
ORCID: 0000-0002-2540-5288

Izumi Nagatomo (I)

Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Osaka, Japan.
ORCID: 0000-0001-5382-4327

Hiroshi Kida (H)

Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Osaka, Japan.
ORCID: 0000-0002-9351-7855

Genichiro Ishii (G)

Division of Pathology, National Cancer Center Hospital East, Chiba, Japan.
ORCID: 0000-0001-8637-3323

Tomohiro Miyoshi (T)

Department of Thoracic Surgery, National Cancer Center Hospital East, Chiba, Japan.

Keiju Aokage (K)

Department of Thoracic Surgery, National Cancer Center Hospital East, Chiba, Japan.
ORCID: 0000-0003-3193-9646

Kazuhiro Kakimi (K)

Department of Pathology, University of Texas Southwestern Medical Center, Dallas TX, USA.
ORCID: 0000-0003-2631-3040

Seishi Ogawa (S)

Department of Pathology and Tumor Biology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
ORCID: 0000-0002-7778-5374

Meinoshin Okumura (M)

Department of General Thoracic Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.

Masatoshi Eto (M)

Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
ORCID: 0000-0002-3312-9930

Atsushi Kumanogoh (A)

Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Osaka, Japan.

Masahiro Tsuboi (M)

Department of Thoracic Surgery, National Cancer Center Hospital East, Chiba, Japan.
ORCID: 0000-0003-3031-5807

Hiroyoshi Nishikawa (H)

Division of Cancer Immunology, Research Institute/Exploratory Oncology Research & Clinical Trial Center (EPOC), National Cancer Center, Tokyo/Chiba, Japan.
Department of Immunology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
ORCID: 0000-0001-6563-9807

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Highly immunogenic cancer cells require...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD8+ › Highly immunogenic cancer cells require...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs du poumon › Tumeurs des bronches › Carcinome bronchogénique › Carcinome pulmonaire non à petites cellules › Highly immunogenic cancer cells require...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Highly immunogenic cancer cells require...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs du poumon › Highly immunogenic cancer cells require...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Highly immunogenic cancer cells require...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée BALB C › Highly immunogenic cancer cells require...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souches mutantes de souris › Souris nude › Highly immunogenic cancer cells require...
questionsmedicales.fr › Phénomènes du système immunitaire › Échappement de la tumeur à la surveillance immunitaire › Highly immunogenic cancer cells require...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Microenvironnement tumoral › Highly immunogenic cancer cells require...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Voie de signalisation Wnt › Highly immunogenic cancer cells require...