Role of Cytokines in Vitiligo: Pathogenesis and Possible Targets for Old and New Treatments.
Autoimmune Diseases
/ drug therapy
Biological Products
/ therapeutic use
Cytokines
/ metabolism
Exonucleases
/ genetics
HLA-DQ beta-Chains
/ genetics
HLA-DRB1 Chains
/ genetics
Humans
Interferon-gamma
/ antagonists & inhibitors
Keratinocytes
/ metabolism
Melanocytes
/ pathology
Pigmentation
/ physiology
Skin
/ pathology
Tumor Necrosis Factor-alpha
/ antagonists & inhibitors
Vitiligo
/ drug therapy
autoimmune diseases
biological drugs
biologics
depigmentation
dermatoses
inflammation
interleukins
oxidative stress
skin
vitiligo
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
22 Oct 2021
22 Oct 2021
Historique:
received:
27
09
2021
revised:
18
10
2021
accepted:
20
10
2021
entrez:
13
11
2021
pubmed:
14
11
2021
medline:
30
12
2021
Statut:
epublish
Résumé
Vitiligo is a chronic autoimmune dermatosis of which the pathogenesis remains scarcely known. A wide variety of clinical studies have been proposed to investigate the immune mediators which have shown the most recurrency. However, such trials have produced controversial results. The aim of this review is to summarize the main factors involved in the pathogenesis of vitiligo, the latest findings regarding the cytokines involved and to evaluate the treatments based on the use of biological drugs in order to stop disease progression and achieve repigmentation. According to the results, the most recurrent studies dealt with inhibitors of IFN-gamma and TNF-alpha. It is possible that, given the great deal of cytokines involved in the lesion formation process of vitiligo, other biologics could be developed in the future to be used as adjuvants and/or to entirely replace the treatments that have proven to be unsatisfactory so far.
Identifiants
pubmed: 34768860
pii: ijms222111429
doi: 10.3390/ijms222111429
pmc: PMC8584117
pii:
doi:
Substances chimiques
Biological Products
0
Cytokines
0
HLA-DQ beta-Chains
0
HLA-DQB1 antigen
0
HLA-DRB1 Chains
0
HLA-DRB4*01:01 antigen
0
IFNG protein, human
0
TNF protein, human
0
Tumor Necrosis Factor-alpha
0
Interferon-gamma
82115-62-6
Exonucleases
EC 3.1.-
MYG1 protein, human
EC 3.1.-
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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