Mesothelial-to-Mesenchymal Transition and Exosomes in Peritoneal Metastasis of Ovarian Cancer.
Ascitic Fluid
/ chemistry
Carcinoma, Ovarian Epithelial
/ pathology
Cell Line, Tumor
Cytokines
/ analysis
Epithelial-Mesenchymal Transition
/ physiology
Epithelium
/ pathology
Exosomes
/ metabolism
Female
Humans
Intercellular Signaling Peptides and Proteins
/ analysis
Ovarian Neoplasms
/ pathology
Peritoneal Neoplasms
/ secondary
Peritoneum
/ pathology
exosomes
mesothelial-to-mesenchymal transition
ovarian cancer
peritoneal metastasis
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
25 Oct 2021
25 Oct 2021
Historique:
received:
06
10
2021
revised:
18
10
2021
accepted:
21
10
2021
entrez:
13
11
2021
pubmed:
14
11
2021
medline:
15
12
2021
Statut:
epublish
Résumé
Most patients with ovarian cancer (OvCA) present peritoneal disseminated disease at the time of diagnosis. During peritoneal metastasis, cancer cells detach from the primary tumor and disseminate through the intraperitoneal fluid. The peritoneal mesothelial cell (PMC) monolayer that lines the abdominal cavity is the first barrier encountered by OvCA cells. Subsequent progression of tumors through the peritoneum leads to the accumulation into the peritoneal stroma of a sizeable population of carcinoma-associated fibroblasts (CAFs), which is mainly originated from a mesothelial-to-mesenchymal transition (MMT) process. A common characteristic of OvCA patients is the intraperitoneal accumulation of ascitic fluid, which is composed of cytokines, chemokines, growth factors, miRNAs, and proteins contained in exosomes, as well as tumor and mesothelial suspended cells, among other components that vary in proportion between patients. Exosomes are small extracellular vesicles that have been shown to mediate peritoneal metastasis by educating a pre-metastatic niche, promoting the accumulation of CAFs via MMT, and inducing tumor growth and chemoresistance. This review summarizes and discusses the pivotal role of exosomes and MMT as mediators of OvCA peritoneal colonization and as emerging diagnostic and therapeutic targets.
Identifiants
pubmed: 34768926
pii: ijms222111496
doi: 10.3390/ijms222111496
pmc: PMC8584135
pii:
doi:
Substances chimiques
Cytokines
0
Intercellular Signaling Peptides and Proteins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministry of Economy, Industry and Competitiveness
ID : SAF2016-77096-R
Organisme : Spanish National Research Council
ID : 2020AEP018
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