Signal Transduction of Mineralocorticoid and Angiotensin II Receptors in the Central Control of Sodium Appetite: A Narrative Review.
aldosterone
angiotensin II
mesolimbic dopaminergic system
organum vasculosum lamina terminalis
oxytocin
paraventricular nucleus
sodium appetite
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
29 Oct 2021
29 Oct 2021
Historique:
received:
29
09
2021
revised:
16
10
2021
accepted:
25
10
2021
entrez:
13
11
2021
pubmed:
14
11
2021
medline:
15
12
2021
Statut:
epublish
Résumé
Sodium appetite is an innate behavior occurring in response to sodium depletion that induces homeostatic responses such as the secretion of the mineralocorticoid hormone aldosterone from the zona glomerulosa of the adrenal cortex and the stimulation of the peptide hormone angiotensin II (ANG II). The synergistic action of these hormones signals to the brain the sodium appetite that represents the increased palatability for salt intake. This narrative review summarizes the main data dealing with the role of mineralocorticoid and ANG II receptors in the central control of sodium appetite. Appropriate keywords and MeSH terms were identified and searched in PubMed. References to original articles and reviews were examined, selected, and discussed. Several brain areas control sodium appetite, including the nucleus of the solitary tract, which contains aldosterone-sensitive HSD2 neurons, and the organum vasculosum lamina terminalis (OVLT) that contains ANG II-sensitive neurons. Furthermore, sodium appetite is under the control of signaling proteins such as mitogen-activated protein kinase (MAPK) and inositol 1,4,5-thriphosphate (IP3). ANG II stimulates salt intake via MAPK, while combined ANG II and aldosterone action induce sodium intake via the IP3 signaling pathway. Finally, aldosterone and ANG II stimulate OVLT neurons and suppress oxytocin secretion inhibiting the neuronal activity of the paraventricular nucleus, thus disinhibiting the OVLT activity to aldosterone and ANG II stimulation.
Identifiants
pubmed: 34769164
pii: ijms222111735
doi: 10.3390/ijms222111735
pmc: PMC8584094
pii:
doi:
Substances chimiques
Receptors, Angiotensin
0
Receptors, Mineralocorticoid
0
Sodium, Dietary
0
Angiotensin II
11128-99-7
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Best Pract Res Clin Endocrinol Metab. 2003 Dec;17(4):471-503
pubmed: 14687585
J Comp Neurol. 1982 Mar 1;205(3):260-72
pubmed: 6122696
Ann Endocrinol (Paris). 1974 Mar-Apr;35(2):149-52
pubmed: 4419272
Appetite. 1998 Jun;30(3):297-307
pubmed: 9632460
Ann N Y Acad Sci. 1969 May 15;157(2):875-93
pubmed: 5255644
Exp Physiol. 1992 Sep;77(5):761-4
pubmed: 1418958
Brain Res. 1992 Oct 30;594(2):295-300
pubmed: 1450955
Behav Biol. 1974 Mar;10(3):313-27
pubmed: 4815155
J Neuroendocrinol. 2003 Aug;15(8):725-31
pubmed: 12834432
Peptides. 2021 Feb;136:170439
pubmed: 33166587
Brain Res. 1981 May 4;211(2):355-66
pubmed: 7237128
Ann Endocrinol (Paris). 1985;46(2):113-7
pubmed: 4037704
Am J Clin Nutr. 2012 Jan;95(1):123-9
pubmed: 22189260
Neuroscientist. 2006 Feb;12(1):80-91
pubmed: 16394195
J Comp Neurol. 2001 Aug 6;436(4):430-55
pubmed: 11447588
Proc Natl Acad Sci U S A. 1996 Jul 9;93(14):7397-404
pubmed: 8693005
Prog Biophys Mol Biol. 1985;46(3):163-83
pubmed: 2418458
Int J Mol Sci. 2021 Apr 27;22(9):
pubmed: 33925539
Kidney Int Suppl. 1992 Jun;37:S97-101
pubmed: 1321310
Physiol Behav. 1973 Feb;10(2):379-84
pubmed: 4708503
Brain Res. 1977 Feb 18;122(2):299-312
pubmed: 189877
Handb Clin Neurol. 2021;180:203-215
pubmed: 34225930
Am J Physiol. 1999 May;276(5):R1339-45
pubmed: 10233025
Brain Res. 1985 Dec 16;359(1-2):224-32
pubmed: 4075146
Pharmacol Biochem Behav. 1987 Apr;26(4):771-9
pubmed: 3602034
Curr Pharm Des. 2014;20(42):6702-13
pubmed: 25190061
J Neurosci. 2004 Oct 20;24(42):9276-81
pubmed: 15496663
Am J Anat. 1967 May;120(3):605-10
pubmed: 4166777
J Comp Neurol. 1983 Nov 1;220(3):280-98
pubmed: 6315785
J Comp Neurol. 2000 Feb 21;417(4):448-66
pubmed: 10701866
Ann N Y Acad Sci. 1989;575:171-91; discussion 192-3
pubmed: 2699187
J Comp Physiol Psychol. 1964 Dec;58:396-402
pubmed: 14241053
Behav Brain Funct. 2010 Oct 25;6:64
pubmed: 20974001
Neuron. 2007 Apr 5;54(1):59-72
pubmed: 17408578
J Biol Chem. 2013 Mar 22;288(12):8187-8197
pubmed: 23386604
Am J Physiol Renal Physiol. 2009 Sep;297(3):F559-76
pubmed: 19261742
Results Probl Cell Differ. 2009;48:65-90
pubmed: 19582412
Brain Res. 1983 Jan 3;258(1):123-6
pubmed: 24010174
Neuroscientist. 2020 Dec 9;:1073858420974336
pubmed: 33292070
Braz J Med Biol Res. 1998 Dec;31(12):1597-600
pubmed: 9951557
J Neuroendocrinol. 2013 Feb;25(2):97-106
pubmed: 22913624
Physiol Rep. 2021 Jan;9(2):e14714
pubmed: 33463885
Am J Physiol Heart Circ Physiol. 2001 Nov;281(5):H2241-51
pubmed: 11668089
Am J Physiol Cell Physiol. 2006 Mar;290(3):C852-61
pubmed: 16251476
Am J Physiol. 1996 Jan;270(1 Pt 2):R162-8
pubmed: 8769798
Brain Res. 2006 Oct 18;1115(1):54-64
pubmed: 16935272
N Engl J Med. 1999 Sep 2;341(10):709-17
pubmed: 10471456
Brain Res. 1991 Mar 15;543(2):213-8
pubmed: 1676328
Physiol Rev. 1998 Jul;78(3):583-686
pubmed: 9674690
Curr Hypertens Rep. 2017 Jun;19(6):50
pubmed: 28528375
Exp Physiol. 2009 Jan;94(1):130-7
pubmed: 18723579
J Comp Neurol. 1994 Mar 15;341(3):289-314
pubmed: 7515078
Am J Physiol Regul Integr Comp Physiol. 2013 Feb;304(3):R252-9
pubmed: 23193117
J Comp Neurol. 1993 Mar 8;329(2):201-29
pubmed: 8454730
Nucl Recept Signal. 2007 Nov 30;5:e012
pubmed: 18174920
J Comp Neurol. 2003 Sep 1;463(4):434-72
pubmed: 12836178
Hypertension. 2006 Dec;48(6):1151-9
pubmed: 17075030
Brain Res. 2019 Oct 1;1720:146299
pubmed: 31220425
Regul Pept. 1996 Oct 8;66(1-2):83-5
pubmed: 8899898
Behav Neurosci. 1983 Oct;97(5):746-58
pubmed: 6639747
Brain Res. 2004 Jul 30;1016(1):129-34
pubmed: 15234261
Am J Physiol. 1965 Jun;208:1281-5
pubmed: 14301393
Brain Res. 1993 Jan 8;600(1):20-6
pubmed: 8422586
Acta Physiol Scand Suppl. 1964;:SUPPL 232:1-55
pubmed: 14229500
Acta Neurobiol Exp (Wars). 1994;54(3):253-7
pubmed: 7817841
Hypertension. 2003 Oct;42(4):793-7
pubmed: 12953013
Brain Struct Funct. 2019 Jan;224(1):387-417
pubmed: 30343334
J Comp Neurol. 1993 Jun 1;332(1):1-20
pubmed: 7685778
Ann Endocrinol (Paris). 1974 Mar-Apr;35(2):153-5
pubmed: 4424424
Brain Res Bull. 1992 Jan;28(1):73-87
pubmed: 1540848
Science. 1984 Jan 27;223(4634):403-5
pubmed: 6691151
Am J Physiol. 1991 Jun;260(6 Pt 2):R1082-8
pubmed: 2058736
Neurosci Lett. 1981 Sep 25;25(3):201-4
pubmed: 7290524
Endocrinology. 1986 Apr;118(4):1726-8
pubmed: 2936598
Curr Pharm Des. 2012;18(30):4714-24
pubmed: 22794200
Am J Physiol. 1999 Jul;277(1):R209-19
pubmed: 10409275
Behav Neurosci. 2006 Jun;120(3):571-9
pubmed: 16768609
J Manag Care Pharm. 2007 Oct;13(8 Suppl B):9-20
pubmed: 17970613
Horm Behav. 2016 Mar;79:28-36
pubmed: 26730722
Nat Neurosci. 2017 Feb;20(2):167-169
pubmed: 27918529
Endocr Metab Immune Disord Drug Targets. 2020;20(1):15-24
pubmed: 31237219
J Comp Neurol. 2006 Jan 20;494(3):515-27
pubmed: 16320254
Am J Physiol. 1994 Dec;267(6 Pt 1):E828-36
pubmed: 7810623
Am J Physiol. 1971 May;220(5):1172-7
pubmed: 5574634
J Neurosci. 2014 Jul 9;34(28):9249-60
pubmed: 25009258
Brain Res. 1984 Nov 26;322(2):365-8
pubmed: 6509326
Exp Brain Res. 1975 May 22;22(5):525-40
pubmed: 1149843
Physiol Behav. 1986;37(5):695-9
pubmed: 3774902
Endocrinology. 1993 Sep;133(3):1239-46
pubmed: 8396014
Hypertension. 1985 Mar-Apr;7(2):262-7
pubmed: 2858449
Science. 1991 Jun 28;252(5014):1813-6
pubmed: 2063193
Kidney Int. 2000 Apr;57(4):1337-45
pubmed: 10760064
Brain Res. 1992 May 29;581(2):208-16
pubmed: 1393529
Am J Physiol Heart Circ Physiol. 2009 May;296(5):H1425-33
pubmed: 19286949
Hypertension. 2001 Jun;37(6):1458-64
pubmed: 11408395
Proc Natl Acad Sci U S A. 1984 Dec;81(24):7812-6
pubmed: 6096858
J Renin Angiotensin Aldosterone Syst. 2001 Mar;2(1):4-10
pubmed: 11881054
Am J Physiol Regul Integr Comp Physiol. 2005 Jun;288(6):R1673-81
pubmed: 15650122
Brain Res. 1988 Apr 26;447(1):178-82
pubmed: 3382949
J Neurosci. 2006 Jan 11;26(2):411-7
pubmed: 16407537
Brain Res. 1981 Dec 28;230(1-2):1-23
pubmed: 7317773
Am J Physiol. 1999 Jan;276(1):R251-8
pubmed: 9887203
Am J Physiol Regul Integr Comp Physiol. 2004 Dec;287(6):R1325-34
pubmed: 15308489
Am J Physiol Regul Integr Comp Physiol. 2004 Aug;287(2):R487; author reply R487-8
pubmed: 15271682
J Comp Physiol Psychol. 1974 Sep;87(3):422-39
pubmed: 4370364
J Neurosci. 2002 Jun 1;22(11):RC225
pubmed: 12040084
Brain Res Bull. 1991 Sep-Oct;27(3-4):397-401
pubmed: 1959037
Pharmacol Biochem Behav. 1983 Aug;19(2):335-8
pubmed: 6634883
J Neurosci. 2000 Oct 15;20(20):7743-51
pubmed: 11027237
Behav Neurosci. 1990 Aug;104(4):637-42
pubmed: 2206433
Behav Cogn Neurosci Rev. 2002 Dec;1(4):281-96
pubmed: 17712985
Behav Neurosci. 1984 Apr;98(2):356-60
pubmed: 6721932
Physiol Behav. 1993 Jul;54(1):129-34
pubmed: 8327591
Folia Med (Plovdiv). 2013 Jul-Dec;55(3-4):63-9
pubmed: 24712284
Am J Physiol. 1998 Nov;275(5 Pt 2):R1431-7
pubmed: 9791058
Int J Hypertens. 2013;2013:175428
pubmed: 23573410
Am J Physiol Regul Integr Comp Physiol. 2007 Mar;292(3):R1338-48
pubmed: 17068161
J Comp Neurol. 2006 Jul 10;497(2):223-50
pubmed: 16705681
J Comp Neurol. 2006 Aug 1;497(4):646-57
pubmed: 16739197
J Comp Physiol Psychol. 1965 Feb;59:49-56
pubmed: 14282407
J Clin Invest. 1997 Mar 1;99(5):855-60
pubmed: 9062342
Am J Physiol. 1997 Oct;273(4):R1299-308
pubmed: 9362293
Nature. 2019 Apr;568(7750):93-97
pubmed: 30918407
Neuroscience. 2006 Sep 15;141(4):1995-2005
pubmed: 16828976
J Comp Physiol Psychol. 1981 Feb;95(1):1-25
pubmed: 7217404
J Comp Physiol Psychol. 1982 Aug;96(4):604-14
pubmed: 7119178
Kidney Int. 2000 Apr;57(4):1329-36
pubmed: 10760063
J Comp Physiol Psychol. 1970 Nov;73(2):284-90
pubmed: 5493269
Cell Tissue Res. 1981;214(2):323-41
pubmed: 6894105
Neuroscience. 2002;111(2):379-87
pubmed: 11983323
Cell Tissue Res. 1978 Sep 26;192(3):423-35
pubmed: 699026
Brain Res. 1998 Dec 7;813(2):283-302
pubmed: 9838165
Am J Physiol. 1982 Jan;242(1):R51-63
pubmed: 6800268
Physiol Behav. 2002 Apr 1;75(4):443-8
pubmed: 12062308
Physiol Behav. 1992 Sep;52(3):499-504
pubmed: 1409911
Front Neuroendocrinol. 1997 Jul;18(3):292-353
pubmed: 9237080
Science. 1973 Sep 21;181(4105):1172-5
pubmed: 4353653
Brain Res. 1994 May 9;645(1-2):123-34
pubmed: 8062074
Pharmacol Biochem Behav. 1990 Dec;37(4):821-4
pubmed: 1982697
Science. 1967 Sep 1;157(3792):1077-9
pubmed: 6036241
Science. 1980 Nov 14;210(4471):791-3
pubmed: 6254147
Appetite. 1995 Dec;25(3):231-40
pubmed: 8746963
FEBS Lett. 1992 Feb 24;298(2-3):257-60
pubmed: 1544458
Brain Res. 2021 Feb 1;1752:147223
pubmed: 33358728
Nat Rev Nephrol. 2018 Jan;14(1):11-25
pubmed: 29129925
Am J Physiol Regul Integr Comp Physiol. 2001 Jun;280(6):R1853-64
pubmed: 11353692
Neuroscience. 1985 May;15(1):61-7
pubmed: 4010935
Endocrinology. 1997 Feb;138(2):613-6
pubmed: 9002994
Exp Brain Res. 1978 Aug 15;32(4):529-47
pubmed: 689127
Behav Neurosci. 1987 Aug;101(4):560-7
pubmed: 2820437
J Comp Physiol Psychol. 1967 Apr;63(2):252-7
pubmed: 6050031
Am J Physiol. 1987 May;252(5 Pt 2):R925-9
pubmed: 3578557
J Comp Neurol. 1998 Apr 27;394(1):48-63
pubmed: 9550142
Cell. 2020 Jan 9;180(1):25-32
pubmed: 31923398
Nat Neurosci. 2017 Feb;20(2):230-241
pubmed: 27991901
Am J Physiol. 1967 Jan;212(1):113-8
pubmed: 6015991
Physiol Rev. 2010 Jan;90(1):259-89
pubmed: 20086078
Physiol Behav. 1984 Apr;32(4):677-81
pubmed: 6484017
Exp Physiol. 2008 Feb;93(2):177-209
pubmed: 17981930
Neuron. 2017 Sep 27;96(1):190-206.e7
pubmed: 28957668