Cationic Peptides and Their Cu(II) and Ni(II) Complexes: Coordination and Biological Characteristics.
Cu(II) complexes
LPS-neutralization
Ni(II) complexes
anti-inflammatory
cationic peptides
potentiometric titration
spectroscopic methods
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
06 Nov 2021
06 Nov 2021
Historique:
received:
05
10
2021
revised:
26
10
2021
accepted:
27
10
2021
entrez:
13
11
2021
pubmed:
14
11
2021
medline:
7
1
2022
Statut:
epublish
Résumé
Antimicrobial peptides are a promising group of compounds used for the treatment of infections. In some cases, metal ions are essential to activate these molecules. Examples of metalloantibiotics are, for instance, bleomycin and dermcidin. This study is focused on three new pseudopeptides with potential biological activity. The coordination behavior of all ligands with Cu(II) and Ni(II) ions has been examined. Various analytical methods such as potentiometric titration, UV-Vis and CD spectroscopies, and mass spectrometry were used. All compounds are convenient chelators for metal ion-binding. Two of the ligands tested have histidine residues. Surprisingly, imidazole nitrogen is not involved in the coordination of the metal ion. The
Identifiants
pubmed: 34769458
pii: ijms222112028
doi: 10.3390/ijms222112028
pmc: PMC8584440
pii:
doi:
Substances chimiques
Antimicrobial Peptides
0
Cations
0
Coordination Complexes
0
Ligands
0
Peptides
0
Copper
789U1901C5
Nickel
7OV03QG267
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Wrocław Medical University
ID : STM.D080.20.2020
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