Insights into Intra-Tumoral Heterogeneity: Transcriptional Profiling of Chemoresistant MPM Cell Subpopulations Reveals Involvement of NFkB and DNA Repair Pathways and Contributes a Prognostic Signature.

Aldehyde Oxidoreductases / metabolism Cell Line, Tumor Clonal Evolution DNA Repair Drug Resistance, Neoplasm Flow Cytometry / methods Humans Mesothelioma, Malignant / drug therapy NF-kappa B / metabolism Prognosis Survival Rate
ALDH Cancer Stem Cell (CSC) DNA repair NFkB butein chemoresistance gene expression intra-tumoral heterogeneity (ITH) mesothelioma

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
08 Nov 2021
Historique:
received: 12 10 2021
revised: 31 10 2021
accepted: 03 11 2021
entrez: 13 11 2021
pubmed: 14 11 2021
medline: 12 1 2022
Statut: epublish

Résumé

Chemoresistance is a hallmark of malignant pleural mesothelioma (MPM) management and the expression of ALDH1A3 is responsible for the survival and activity of MPM chemoresistant cell subpopulations (ALDH

Identifiants

DOI: 10.3390/ijms222112071 PMID: 34769499 PMC: PMC8585077
pubmed: 34769499
pii: ijms222112071
doi: 10.3390/ijms222112071
pmc: PMC8585077
pii:
doi:

Substances chimiques

NF-kappa B 0
Aldehyde Oxidoreductases EC 1.2.-
aldehyde dehydrogenase (NAD(P)+) EC 1.2.1.5

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Références

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Auteurs

Mario Cioce (M)

Department of Medicine, R.U. in Molecular Medicine and Biotechnology, University Campus Bio-Medico of Rome, 00128 Rome, Italy.
ORCID: 0000-0001-8129-6664

Andrea Sacconi (A)

Clinical Trial Center, Biostatistics and Bioinformatics Unit, IRCCS Regina Elena National Cancer Institute, 00144 Rome, Italy.

Harvey I Pass (HI)

Division of General Thoracic Surgery, Department of Cardiothoracic Surgery, New York University Langone Medical Center, New York, NY 10016, USA.

Claudia Canino (C)

Radiation Oncology Unit, UPMC Hillmann Cancer Center, San Pietro Hospital FBF, 00189 Rome, Italy.

Sabrina Strano (S)

Small Animal Facility Unit, Department of Research, Diagnosis and Innovative Technologies, IRCCS Regina Elena National Cancer Institute, 00144 Rome, Italy.
ORCID: 0000-0002-6341-4230

Giovanni Blandino (G)

Oncogenomic and Epigenetic Unit, IRCCS Regina Elena National Cancer Institute, 00144 Rome, Italy.

Vito Michele Fazio (VM)

Department of Medicine, R.U. in Molecular Medicine and Biotechnology, University Campus Bio-Medico of Rome, 00128 Rome, Italy.
Laboratory of Oncology, Institute of Translational Pharmacology, National Research Council of Italy (CNR), 00133 Rome, Italy.
Fondazione IRCCS Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, Italy.

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxidoreductases acting on aldehyde or oxo group donors › Aldehyde oxidoreductases › Insights into Intra-Tumoral Heterogeneity:...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Insights into Intra-Tumoral Heterogeneity:...
questionsmedicales.fr › Phénomènes génétiques › Évolution clonale › Insights into Intra-Tumoral Heterogeneity:...
questionsmedicales.fr › Phénomènes génétiques › Réparation de l'ADN › Insights into Intra-Tumoral Heterogeneity:...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Résistance aux médicaments antinéoplasiques › Insights into Intra-Tumoral Heterogeneity:...
questionsmedicales.fr › Techniques d'investigation › Techniques cytologiques › Cytophotométrie › Cytométrie en flux › Insights into Intra-Tumoral Heterogeneity:...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Insights into Intra-Tumoral Heterogeneity:...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs de la plèvre › Mésothéliome malin › Insights into Intra-Tumoral Heterogeneity:...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteur de transcription NF-kappa B › Insights into Intra-Tumoral Heterogeneity:...
questionsmedicales.fr › Diagnostic › Pronostic › Insights into Intra-Tumoral Heterogeneity:...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Registre civil › Mortalité › Taux de survie › Insights into Intra-Tumoral Heterogeneity:...