Cognitive function and oral health in relapsing-remitting multiple sclerosis.
Cognition
Multiple sclerosis
Neurological disorder
Oral health
Relapsing–remitting
Journal
Clinical oral investigations
ISSN: 1436-3771
Titre abrégé: Clin Oral Investig
Pays: Germany
ID NLM: 9707115
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
received:
11
08
2021
accepted:
02
11
2021
pubmed:
14
11
2021
medline:
9
3
2022
entrez:
13
11
2021
Statut:
ppublish
Résumé
Multiple sclerosis (MS) is often associated with reduced cognitive function, and there is also emerging evidence of a heightened vulnerability to oral health problems. However, although links between cognitive function and oral health have been identified in other special populations, it remains to be established whether this relationship is also evident for people with MS. The aim of this study was to provide the first empirical test of whether there is a relationship between cognitive function and oral health in people diagnosed with relapsing-remitting multiple sclerosis (RRMS). One hundred and eleven individuals were evaluated: 56 people diagnosed with RRMS and 55 demographically matched healthy controls. All participants completed an objective oral health assessment as well as a standardized battery that assessed six distinct neurocognitive domains. Relative to controls, people with RRMS presented with higher rates of decayed teeth and mild gingivitis, and also performed more poorly in three of the six neurocognitive domains assessed (language, complex attention, and executive function). However, for the RRMS group, no associations emerged between oral health with performance on any of the six neurocognitive domains. These data cross-validate previous research which shows people with RRMS are more likely to present with both reduced cognitive function and poorer oral health, but also extends this literature in a meaningful way by additionally showing for the first time that these clinical features are unrelated in RRMS. The findings emphasize the need for early assessment of both oral health and cognitive function in people with RRMS so that appropriate interventions and support can be put in place for each of these clinical symptoms.
Identifiants
pubmed: 34773142
doi: 10.1007/s00784-021-04272-1
pii: 10.1007/s00784-021-04272-1
doi:
Types de publication
Journal Article
Langues
eng
Pagination
2899-2907Subventions
Organisme : Multiple Sclerosis Research Australia
ID : #19-0739
Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Références
Walton C, King R, Rechtman L et al (2020) Rising prevalence of multiple sclerosis worldwide: insights from the Atlas of MS, third edition. Mult Scler J 26(14):1816–1821. https://doi.org/10.1177/1352458520970841
doi: 10.1177/1352458520970841
Filippi M, Bar-Or A, Piehl F et al (2018) Multiple sclerosis. Nat Rev Dis Primers 4(1):43. https://doi.org/10.1038/s41572-018-0041-4
doi: 10.1038/s41572-018-0041-4
pubmed: 30410033
Desai MK, Brinton RD (2019) Autoimmune disease in women: endocrine transition and risk across the lifespan. Front Endocrinol (Lausanne) 10:265. https://doi.org/10.3389/fendo.2019.00265
doi: 10.3389/fendo.2019.00265
Macías Islas MÁ, Ciampi E (2019) Assessment and impact of cognitive impairment in multiple sclerosis: an overview. Biomedicines 7(1):22. https://doi.org/10.3390/biomedicines7010022
doi: 10.3390/biomedicines7010022
pmcid: 6466345
Mc-Nicholas N, O’Connell K, Yap SM, Killeen RP, Hutchinson M, Mc-Guigan C (2018) Cognitive dysfunction in early multiple sclerosis: a review. QJM 111(6):359–364. https://doi.org/10.1093/qjmed/hcx070
doi: 10.1093/qjmed/hcx070
Chiaravalloti ND, DeLuca J (2008) Cognitive impairment in multiple sclerosis. Lancet Neurol 7(12):1139–1151. https://doi.org/10.1016/S1474-4422(08)70259-X
doi: 10.1016/S1474-4422(08)70259-X
pubmed: 19007738
Langdon DW (2011) Cognition in multiple sclerosis. Curr Opin Neurol 24(3):244–249. https://doi.org/10.1097/WCO.0b013e328346a43b
doi: 10.1097/WCO.0b013e328346a43b
pubmed: 21519256
Rao SM, Leo GJ, Bernardin L, Unverzagt F (1991) Cognitive dysfunction in multiple sclerosis. I. Frequency, patterns, and prediction. Neurology 41(5):685–691. https://doi.org/10.1212/wnl.41.5.685
doi: 10.1212/wnl.41.5.685
pubmed: 2027484
Deloire MS, Ruet A, Hamel D, Bonnet M, Dousset V, Brochet B (2011) MRI predictors of cognitive outcome in early multiple sclerosis. Neurology 76(13):1161–1167. https://doi.org/10.1212/WNL.0b013e318212a8be
doi: 10.1212/WNL.0b013e318212a8be
pubmed: 21444901
Cotter J, Firth J, Enzinger C et al (2016) Social cognition in multiple sclerosis: a systematic review and meta-analysis. Neurology 87(16):1727–1736. https://doi.org/10.1212/WNL.0000000000003236
doi: 10.1212/WNL.0000000000003236
pubmed: 27655736
pmcid: 5085073
Ziccardi S, Pitteri M, Genova HM, Calabrese M (2021) Social cognition in multiple sclerosis: a 3-year follow-up MRI and behavioral study. Diagnostics (Basel) 11(3):484. https://doi.org/10.3390/diagnostics11030484
doi: 10.3390/diagnostics11030484
Clemens L, Langdon D (2018) How does cognition relate to employment in multiple sclerosis? A systematic review. Mult Scler Relat Disord 26:183–191. https://doi.org/10.1016/j.msard.2018.09.018
doi: 10.1016/j.msard.2018.09.018
pubmed: 30268039
Northridge ME, Kumar A, Kaur R (2020) Disparities in access to oral health care. Annu Rev Public Health 41:513–535. https://doi.org/10.1146/annurev-publhealth-040119-094318
doi: 10.1146/annurev-publhealth-040119-094318
pubmed: 31900100
pmcid: 7125002
Sexton C, Lalloo R, Stormon N et al (2019) Oral health and behaviours of people living with multiple sclerosis in Australia. Community Dent Oral Epidemiol 47(3):201–209. https://doi.org/10.1111/cdoe.12445
doi: 10.1111/cdoe.12445
pubmed: 30618108
Elemek E, Almas K (2013) Multiple sclerosis and oral health: an update. N Y State Dent J 79:16–21
pubmed: 23767394
Sheu JJ, Lin HC (2013) Association between multiple sclerosis and chronic periodontitis: a population-based pilot study. Eur J Neurol 20:1053–1059. https://doi.org/10.1111/ene.12103
doi: 10.1111/ene.12103
pubmed: 23398363
Fragoso YD, Alves HHC, Alves LC et al (2010) Dental care in multiple sclerosis: an overlooked and under-assessed condition. J Disabil Oral Health 11:53–56
Covello F, Ruoppolo G, Carissimo C et al (2020) Multiple sclerosis: impact on oral hygiene, dysphagia, and quality of Life. Int J Environ Res Public Health 17(11):3979. https://doi.org/10.3390/ijerph17113979
doi: 10.3390/ijerph17113979
pmcid: 7312593
Cockburn N, Pateman K, Pradhan A, Campbell J, Ford P (2017) Oral health and quality of life in people living with multiple sclerosis. J Disability Oral Health 18:26–31
Manchery N, Henry JD, Nangle MR (2020) A systematic review of oral health in people with multiple sclerosis. Community Dent and Oral Epidemiol 48(2):89–100. https://doi.org/10.1111/cdoe.12512
doi: 10.1111/cdoe.12512
Cockburn N, Pateman K, Taing MW, Pradhan A, Ford PJ (2017) Managing the oral side effects of medications used to treat multiple sclerosis. Aust Dent J 62:331–336. https://doi.org/10.1111/adj.12510
doi: 10.1111/adj.12510
pubmed: 28276076
Wu B, Fillenbaum GG, Plassman BL, Guo L (2016) Association between oral health and cognitive status: a systematic review. J Am Geriatr Soc 64(4):739–751. https://doi.org/10.1111/jgs.14036
doi: 10.1111/jgs.14036
pubmed: 27037761
pmcid: 4986993
Manchery N, Nangle MR, Grainger SA et al Event-based but not time-based prospective memory is related to oral health in late adulthood. Gerontology 67(1):112–120. https://doi.org/10.1159/000511607
Nangle MR, Riches J, Grainger SA, Manchery N, Sachdev PS, Henry JD (2019) Oral health and cognitive function in older adults: a systematic review. Gerontology 65(6):659–672. https://doi.org/10.1159/000496730
doi: 10.1159/000496730
pubmed: 30904915
Thompson AJ, Banwell BL, Barkhof F et al (2018) Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria. Lancet Neurol 17(2):162–173. https://doi.org/10.1016/S1474-4422(17)30470-2
doi: 10.1016/S1474-4422(17)30470-2
pubmed: 29275977
Sachdev PS, Blacker D, Blazer DG et al (2014) Classifying neurocognitive disorders: the DSM-5 approach. Nat Rev Neurol 10(11):634–642. https://doi.org/10.1038/nrneurol.2014.181
doi: 10.1038/nrneurol.2014.181
pubmed: 25266297
Warrington EK, James M (1991) The visual object and space perception battery. Bury St Edmunds: Thames Valley Test Company, England
Nelson HE, Willison J (1991) National Adult Reading Test (NART) test manual, 2nd edn. NFER-NELSON Publishing Company Ltd, Windsor
Benedict RHB, Schretlen D, Groninger L, Brandt J (1998) Hopkins verbal learning test – revised: normative data and analysis of inter-form and test-retest reliability. Clin Neuropsychol 12(1):43–55. https://doi.org/10.1076/clin.12.1.43.1726
doi: 10.1076/clin.12.1.43.1726
Wechsler D (2008) Wechsler Adult Intelligence Scale—Fourth UK Edition (WAIS-IV UK); Administering and Scoring Manual. The Psychological Corporation, London
Benton AL (1967) Problems of test construction in the field of aphasia. Cortex 3(1):32–58
doi: 10.1016/S0010-9452(67)80005-4
Henry JD, von Hippel W, Molenberghs P, Lee T, Sachdev PS (2016) Clinical assessment of social cognitive function in neurological disorders. Nat Rev Neurol 12(1):28–39. https://doi.org/10.1038/nrneurol.2015.229
doi: 10.1038/nrneurol.2015.229
pubmed: 26670297
Ramfjord SP (1976) The periodontal disease index (PDI). J Periodontol 38(6):602–610. https://doi.org/10.1902/jop.1967.38.6.602
doi: 10.1902/jop.1967.38.6.602
World Health Organization (2013) Oral health surveys-basic methods, 5th edn. World Health Organization, Geneva
Kang J, Wu B, Bunce D, Ide M, Pavitt S, Wu J (2019) Cognitive function and oral health among ageing adults. Community Dent Oral Epidemiol 47:259–266. https://doi.org/10.1111/cdoe.12452
doi: 10.1111/cdoe.12452
pubmed: 30838683
Chen X, Shuman SK, Hodges JS, Gatewood LC, Xu J (2010) Patterns of tooth loss in older adults with and without dementia: a retrospective study based on a Minnesota cohort. J Am Geriatr Soc 58:2300–2307. https://doi.org/10.1111/j.1532-5415.2010.03192.x
doi: 10.1111/j.1532-5415.2010.03192.x
pubmed: 21143439
Lee KH, Choi YY (2019) Association between oral health and dementia in the elderly: a population-based study in Korea. Sci Rep 9(1):14407. https://doi.org/10.1038/s41598-019-50863-0
doi: 10.1038/s41598-019-50863-0
pubmed: 31594986
pmcid: 6783535
Nascimento PC, Castro MML, Magno MB et al (2019) Association between periodontitis and cognitive impairment in adults: a systematic review. Front Neurol 10:323. https://doi.org/10.3389/fneur.2019.00323
doi: 10.3389/fneur.2019.00323
pubmed: 31105630
pmcid: 6492457
Nangle MR, Manchery N (2020) Can chronic oral inflammation and masticatory dysfunction contribute to cognitive impairment? Curr Opin Psychiatry 33:156–162. https://doi.org/10.1097/YCO.0000000000000581
doi: 10.1097/YCO.0000000000000581
pubmed: 31895157
Wu B, Plassman BL, Liang J, Wei L (2007) Cognitive function and dental care utilization among community-dwelling older adults. Am J Public Health 97:2216–2221. https://doi.org/10.2105/AJPH.2007.109934
doi: 10.2105/AJPH.2007.109934
pubmed: 17971546
pmcid: 2089110
Lee KH, Plassman BL, Pan W, Wu B (2016) Mediation effect of oral hygiene on the relationship between cognitive function and oral health in older adults. J Gerontol Nurs 42:30–37. https://doi.org/10.3928/00989134-20151218-03
doi: 10.3928/00989134-20151218-03
pubmed: 26716459
Chen X, Clark JJ, Chen H, Naorungroj S (2015) Cognitive impairment, oral self-care function and dental caries severity in community-dwelling older adults. Gerodontology 32:53–61. https://doi.org/10.1111/ger.12061
doi: 10.1111/ger.12061
pubmed: 23758583
Brochet B, Ruet A (2019) Cognitive impairment in multiple sclerosis with regards to disease duration and clinical phenotypes. Front Neurol 10:261. https://doi.org/10.3389/fneur.2019.00261
doi: 10.3389/fneur.2019.00261
pubmed: 30949122
pmcid: 6435517
Oset M, Stasiolek M, Matysiak M (2020) Cognitive dysfunction in the early stages of multiple sclerosis-how much and how important? Curr Neurol Neurosci Rep 20(7):22. https://doi.org/10.1007/s11910-020-01045-3
doi: 10.1007/s11910-020-01045-3
pubmed: 32444997
pmcid: 7244611
Katsari M, Kasselimis DS, Giogkaraki E et al (2020) A longitudinal study of cognitive function in multiple sclerosis: is decline inevitable? J Neurol 267(5):1464–1475. https://doi.org/10.1007/s00415-020-09720-8
doi: 10.1007/s00415-020-09720-8
pubmed: 32008073
Elshebawy H, Fahmy EM, Elfayoumy NM, Abdelalim AM, Ismail RS (2021) Clinical predictors to cognitive impairment in multiple sclerosis patients. Egypt J Neurol Psychiatry Neurosurg 57:38. https://doi.org/10.1186/s41983-021-00292-6
doi: 10.1186/s41983-021-00292-6