Vascular pythiosis caused by Pythium aphanidermatum: the first case report in Asia.
Antifungal Agents
/ therapeutic use
Azithromycin
/ therapeutic use
Fatal Outcome
Female
Host-Pathogen Interactions
/ drug effects
Humans
Hyphae
/ drug effects
Itraconazole
/ therapeutic use
Middle Aged
Pythiosis
/ diagnosis
Pythium
/ drug effects
Terbinafine
/ therapeutic use
Thailand
Thrombosis
/ microbiology
Asia
Case report
Pythiosis
Pythium
Pythium aphanidermatum
Pythium insidiosum
Journal
European journal of medical research
ISSN: 2047-783X
Titre abrégé: Eur J Med Res
Pays: England
ID NLM: 9517857
Informations de publication
Date de publication:
14 Nov 2021
14 Nov 2021
Historique:
received:
04
05
2021
accepted:
03
11
2021
entrez:
15
11
2021
pubmed:
16
11
2021
medline:
15
3
2022
Statut:
epublish
Résumé
Pythium, soil-borne plant pathogens, are in the class Oomycetes. They are not true fungi, but are related to diatom and algae. There are two human pathogens including P. insidiosum and P. aphanidermatum. To date, only one case of pythiosis caused by P. aphanidermatum has been reported. We present herein the first case of P. aphanidermatum vascular pythiosis in Asia. A 47-year-old Thai woman, living in North Thailand, with ß thalassemia/hemoglobin E presented with acute recurrent arterial insufficiency of both legs. Emergent embolectomy with clot removal was performed. The pathology of the clot exhibited noncaseous granulomatous inflammation with many fungal hyphal elements. PCR identified P. aphanidermatum with 100% identity. Final diagnosis is vascular pythiosis. Unfortunately, the patient eventually expired after treatment with itraconazole, terbinafine, azithromycin, and doxycycline. To date, only one case of pythiosis caused by P. aphanidermatum has been reported. We present herein the first case of P. aphanidermatum vascular pythiosis in Asia.
Sections du résumé
BACKGROUND
BACKGROUND
Pythium, soil-borne plant pathogens, are in the class Oomycetes. They are not true fungi, but are related to diatom and algae. There are two human pathogens including P. insidiosum and P. aphanidermatum. To date, only one case of pythiosis caused by P. aphanidermatum has been reported. We present herein the first case of P. aphanidermatum vascular pythiosis in Asia.
CASE PRESENTATION
METHODS
A 47-year-old Thai woman, living in North Thailand, with ß thalassemia/hemoglobin E presented with acute recurrent arterial insufficiency of both legs. Emergent embolectomy with clot removal was performed. The pathology of the clot exhibited noncaseous granulomatous inflammation with many fungal hyphal elements. PCR identified P. aphanidermatum with 100% identity. Final diagnosis is vascular pythiosis. Unfortunately, the patient eventually expired after treatment with itraconazole, terbinafine, azithromycin, and doxycycline.
CONCLUSIONS
CONCLUSIONS
To date, only one case of pythiosis caused by P. aphanidermatum has been reported. We present herein the first case of P. aphanidermatum vascular pythiosis in Asia.
Identifiants
pubmed: 34775999
doi: 10.1186/s40001-021-00603-w
pii: 10.1186/s40001-021-00603-w
pmc: PMC8591800
doi:
Substances chimiques
Antifungal Agents
0
Itraconazole
304NUG5GF4
Azithromycin
83905-01-5
Terbinafine
G7RIW8S0XP
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
132Informations de copyright
© 2021. The Author(s).
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