Genetics in Congenital Heart Diseases: Unraveling the Link Between Cardiac Morphogenesis, Heart Muscle Disease, and Electrical Disorders.
Arrhythmias
Cardiomyopathies (CMPs)
Congenital heart diseases (CHDs)
Genotype-phenotype correlation
Progressive aspect
Journal
Heart failure clinics
ISSN: 1551-7136
Titre abrégé: Heart Fail Clin
Pays: United States
ID NLM: 101231934
Informations de publication
Date de publication:
Jan 2022
Jan 2022
Historique:
entrez:
15
11
2021
pubmed:
16
11
2021
medline:
26
11
2021
Statut:
ppublish
Résumé
The genetic background of congenital heart diseases (CHDs) is extremely complex, heterogenous, and still majorly to be determined. CHDs can be sporadic or familial. In this article we discuss in detail the phenotypic spectrum of selected genes including MYH7, GATA4, NKX2-5, TBX5, and TBX20. Our goal is to offer the clinician a general overview of the clinical spectrum of the analyzed topics that are traditionally known as causative for CHDs but we underline in this review the possible progressive functional (cardiomyopathy) and electric aspects (arrhythmias) caused by the genetic background.
Identifiants
pubmed: 34776075
pii: S1551-7136(21)00095-7
doi: 10.1016/j.hfc.2021.07.016
pii:
doi:
Substances chimiques
GATA4 Transcription Factor
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
139-153Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Financial conflicts of interest and funding The authors declare no conflict of interest, and funding was not obtained for producing the article.