Cardiovascular Involvement in mtDNA Disease: Diagnosis, Management, and Therapeutic Options.

Cardiomyopathies / etiology Cardiomyopathy, Dilated Cardiomyopathy, Hypertrophic / diagnosis DNA, Mitochondrial / genetics Humans Mitochondrial Diseases / diagnosis
Hypertrophic cardiomyopathy MELAS syndrome Mitochondrial diseases mtDNA

Journal

Heart failure clinics
ISSN: 1551-7136
Titre abrégé: Heart Fail Clin
Pays: United States
ID NLM: 101231934

Informations de publication

Date de publication:
Jan 2022
Historique:
entrez: 15 11 2021
pubmed: 16 11 2021
medline: 26 11 2021
Statut: ppublish

Résumé

Mitochondrial diseases (MD) include an heterogenous group of systemic disorders caused by sporadic or inherited mutations in nuclear or mitochondrial DNA (mtDNA), causing impairment of oxidative phosphorylation system. Hypertrophic cardiomyopathy is the dominant pattern of cardiomyopathy in all forms of mtDNA disease, being observed in almost 40% of the patients. Dilated cardiomyopathy, left ventricular noncompaction, and conduction system disturbances have been also reported. In this article, the authors discuss the current clinical knowledge on MD, focusing on diagnosis and management of mitochondrial diseases caused by mtDNA mutations.

Identifiants

DOI: 10.1016/j.hfc.2021.07.003 PMID: 34776083
pubmed: 34776083
pii: S1551-7136(21)00072-6
doi: 10.1016/j.hfc.2021.07.003
pii:
doi:

Substances chimiques

DNA, Mitochondrial 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

51-60

Informations de copyright

Copyright © 2021 Elsevier Inc. All rights reserved.

Auteurs

Michele Lioncino (M)

Inherited and Rare Cardiovascular Disease Unit, Department of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", Naples.

Emanuele Monda (E)

Inherited and Rare Cardiovascular Disease Unit, Department of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", Naples.

Martina Caiazza (M)

Inherited and Rare Cardiovascular Disease Unit, Department of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", Naples.

Adelaide Fusco (A)

Inherited and Rare Cardiovascular Disease Unit, Department of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", Naples.

Annapaola Cirillo (A)

Inherited and Rare Cardiovascular Disease Unit, Department of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", Naples.

Francesca Dongiglio (F)

Inherited and Rare Cardiovascular Disease Unit, Department of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", Naples.

Vicenzo Simonelli (V)

Division of Neurology, AORN Dei Colli, Monaldi Hospital, Naples.

Simone Sampaolo (S)

Second Division of Neurology, Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, Naples, Italy.

Lucia Ruggiero (L)

Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, Naples, Italy.

Gioacchino Scarano (G)

Inherited and Rare Cardiovascular Disease Unit, Department of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", Naples.

Vicenzo Pota (V)

Department of Women, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Piazza L. Miraglia 2, 80138 Naples, Italy.

Giulia Frisso (G)

Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università di Napoli Federico II, Naples, Italy; CEINGE Biotecnologie Avanzate, Scarl, Naples, Italy; CEINGE Advanced Biotechnologies, 80145 Naples, Italy.

Cristina Mazzaccara (C)

Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università di Napoli Federico II, Naples, Italy; CEINGE Biotecnologie Avanzate, Scarl, Naples, Italy; CEINGE Advanced Biotechnologies, 80145 Naples, Italy.

Giulia D'Amati (G)

Department of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, Rome, Italy.

Gerardo Nigro (G)

Department of Medical Translational Sciences, Division of Cardiology, Monaldi Hospital, University of Campania "Luigi Vanvitelli", Naples, Italy.

Maria Giovanna Russo (MG)

Pediatric Cardiology Unit, Monaldi Hospital, University "Luigi Vanvitelli", Naples, Italy.

Karim Wahbi (K)

APHP, Cochin Hospital, Cardiology Department, FILNEMUS, Paris-Descartes, Sorbonne Paris Cité University, Paris, France.

Giuseppe Limongelli (G)

Inherited and Rare Cardiovascular Disease Unit, Department of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", Naples. Electronic address: limongelligiuseppe@libero.it.

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Classifications MeSH

questionsmedicales.fr › Maladies cardiovasculaires › Cardiopathies › Cardiomyopathies › Cardiovascular Involvement in mtDNA Disease:...
questionsmedicales.fr › Malformations et maladies congénitales, héréditaires et néonatales › Maladies génétiques congénitales › Laminopathies › Cardiomyopathie dilatée › Cardiovascular Involvement in mtDNA Disease:...
questionsmedicales.fr › Maladies cardiovasculaires › Cardiopathies › Valvulopathies › Maladie de la valve aortique › Cardiomyopathie hypertrophique › Cardiovascular Involvement in mtDNA Disease:...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › ADN mitochondrial › Cardiovascular Involvement in mtDNA Disease:...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Cardiovascular Involvement in mtDNA Disease:...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Maladies mitochondriales › Cardiovascular Involvement in mtDNA Disease:...