Cancer catecholamine conundrum.
adrenergic receptors
catecholamines
exercise
stress
Journal
Trends in cancer
ISSN: 2405-8025
Titre abrégé: Trends Cancer
Pays: United States
ID NLM: 101665956
Informations de publication
Date de publication:
02 2022
02 2022
Historique:
received:
26
03
2021
revised:
12
10
2021
accepted:
14
10
2021
pubmed:
16
11
2021
medline:
2
4
2022
entrez:
15
11
2021
Statut:
ppublish
Résumé
Exercise, psychosocial stress, and drugs such as adrenergic agonists and antagonists increase the concentrations of catecholamines and/or alter adrenergic signaling. Intriguingly, exercise studies universally suggest that catecholamines are cancer-inhibiting whereas cancer stress studies typically report the opposite, whereas β-blocker studies show variable effects. Here, we term variable effects of catecholamines in cancer the cancer catecholamine conundrum. Variable effects of catecholamines can potentially be explained by variable expression of nine adrenergic receptor isoforms and by other factors including catecholamine effects on cancer versus immune or endothelial cells. Future studies on catecholamines and cancer should seek to understand the mechanisms that explain variable effects of catecholamines in cancer to utilize beneficial or block detrimental effects of catecholamines in cancer patients.
Identifiants
pubmed: 34776398
pii: S2405-8033(21)00210-7
doi: 10.1016/j.trecan.2021.10.005
pii:
doi:
Substances chimiques
Adrenergic beta-Antagonists
0
Catecholamines
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
110-122Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.