Detecting Liquid Remnants of Solid Tumors: Circulating Tumor DNA Minimal Residual Disease.
Journal
Cancer discovery
ISSN: 2159-8290
Titre abrégé: Cancer Discov
Pays: United States
ID NLM: 101561693
Informations de publication
Date de publication:
01 12 2021
01 12 2021
Historique:
received:
17
05
2021
revised:
24
07
2021
accepted:
05
08
2021
pubmed:
18
11
2021
medline:
6
4
2022
entrez:
17
11
2021
Statut:
ppublish
Résumé
Growing evidence demonstrates that circulating tumor DNA (ctDNA) minimal residual disease (MRD) following treatment for solid tumors predicts relapse. These results suggest that ctDNA MRD could identify candidates for adjuvant therapy and measure response to such treatment. Importantly, factors such as assay type, amount of ctDNA release, and technical and biological background can affect ctDNA MRD results. Furthermore, the clinical utility of ctDNA MRD for treatment personalization remains to be fully established. Here, we review the evidence supporting the value of ctDNA MRD in solid cancers and highlight key considerations in the application of this potentially transformative biomarker. ctDNA analysis enables detection of MRD and predicts relapse after definitive treatment for solid cancers, thereby promising to revolutionize personalization of adjuvant and consolidation therapies.
Identifiants
pubmed: 34785539
pii: 2159-8290.CD-21-0634
doi: 10.1158/2159-8290.CD-21-0634
pmc: PMC8976700
mid: NIHMS1734108
doi:
Substances chimiques
Biomarkers, Tumor
0
Circulating Tumor DNA
0
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2968-2986Subventions
Organisme : NCI NIH HHS
ID : R01 CA188298
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA233578
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA244526
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA254179
Pays : United States
Informations de copyright
©2021 American Association for Cancer Research.
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