Dysfunctions of the paraventricular hypothalamic nucleus induce hypersomnia in mice.
chemogenetics
hypersomnolence disorder
mouse
neuroscience
optogenetics
paraventricular hypothalamic nucleus
wakefulness
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
17 11 2021
17 11 2021
Historique:
received:
29
04
2021
accepted:
16
11
2021
pubmed:
18
11
2021
medline:
15
12
2021
entrez:
17
11
2021
Statut:
epublish
Résumé
Hypersomnolence disorder (HD) is characterized by excessive sleep, which is a common sequela following stroke, infection, or tumorigenesis. HD is traditionally thought to be associated with lesions of wake-promoting nuclei. However, lesions of a single wake-promoting nucleus, or even two simultaneously, did not exert serious HD. Therefore, the specific nucleus and neural circuitry for HD remain unknown. Here, we observed that the paraventricular nucleus of the hypothalamus (PVH) exhibited higher c-fos expression during the active period (23:00) than during the inactive period (11:00) in mice. Therefore, we speculated that the PVH, in which most neurons are glutamatergic, may represent one of the key arousal-controlling centers. By using vesicular glutamate transporter 2 (vglut2
Identifiants
pubmed: 34787078
doi: 10.7554/eLife.69909
pii: 69909
pmc: PMC8631797
doi:
pii:
Substances chimiques
Vesicular Glutamate Transport Protein 2
0
Banques de données
Dryad
['10.5061/dryad.bg79cnpb6', '10.5061/dryad.x3ffbg7jw', '10.5061/dryad.r4xgxd2db']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2021, Chen et al.
Déclaration de conflit d'intérêts
CC, YZ, SJ, WX, LX, ZW, WQ, ZH No competing interests declared
Références
J Sleep Res. 2021 Sep 12;:e13484
pubmed: 34510626
Curr Biol. 2016 Sep 12;26(17):2301-12
pubmed: 27546576
Neuron. 2017 Jul 19;95(2):368-384.e5
pubmed: 28669546
Cell Metab. 2013 Dec 3;18(6):860-70
pubmed: 24315371
Sci Adv. 2020 Nov 6;6(45):
pubmed: 33158870
Nat Neurosci. 2020 Mar;23(3):398-410
pubmed: 32066984
J Comp Neurol. 1969 Jun;136(2):143-57
pubmed: 4892387
Mo Med. 2018 Jan-Feb;115(1):85-91
pubmed: 30228690
Nat Neurosci. 2010 Dec;13(12):1526-33
pubmed: 21037585
Cereb Cortex. 2017 Jun 1;27(6):3254-3271
pubmed: 28379350
J Neurosci. 2017 Feb 1;37(5):1352-1366
pubmed: 28039375
Nature. 2006 Jun 1;441(7093):589-94
pubmed: 16688184
Science. 2020 Oct 16;370(6514):
pubmed: 33060330
Nature. 2016 Apr 7;532(7597):103-6
pubmed: 27001694
J Comp Neurol. 2005 Mar 28;484(1):43-56
pubmed: 15717303
J Neurosci. 2004 Mar 24;24(12):2974-82
pubmed: 15044536
J Neuropathol Exp Neurol. 2005 Mar;64(3):224-9
pubmed: 15804054
Nat Commun. 2017 Nov 10;8(1):1405
pubmed: 29123082
Nat Neurosci. 2018 Mar;21(3):393-403
pubmed: 29311741
J Neurosci. 2006 Jan 4;26(1):193-202
pubmed: 16399687
Trends Neurosci. 2001 Dec;24(12):726-31
pubmed: 11718878
Electroencephalogr Clin Neurophysiol. 1949 Nov;1(4):455-73
pubmed: 18421835
Curr Biol. 2019 Feb 18;29(4):637-644.e3
pubmed: 30713103
Endocrinology. 2018 Sep 1;159(9):3458-3472
pubmed: 30052854
Front Neurosci. 2019 Jul 30;13:755
pubmed: 31417341
Nature. 1984 Jul 12-18;310(5973):140-1
pubmed: 6377089
Neuron. 2011 Jul 14;71(1):142-54
pubmed: 21745644
Front Neurosci. 2021 Mar 25;15:645877
pubmed: 33841086
Nat Neurosci. 2016 Oct;19(10):1356-66
pubmed: 27595385
Science. 2018 Oct 26;362(6413):429-434
pubmed: 30361367
Mol Psychiatry. 2021 Jul;26(7):2912-2928
pubmed: 33057171
Curr Biol. 2019 Apr 1;29(7):1243-1251.e4
pubmed: 30853436
Nat Commun. 2018 Apr 20;9(1):1576
pubmed: 29679009
Cell Tissue Res. 2019 Jan;375(1):85-91
pubmed: 29911261
Nat Commun. 2019 Aug 1;10(1):3446
pubmed: 31371721
Neuroendocrinology. 1995 Jul;62(1):62-70
pubmed: 7566440
Curr Biol. 2016 Aug 22;26(16):2137-43
pubmed: 27426511
Sci Adv. 2020 Sep 9;6(37):
pubmed: 32917689
Cereb Cortex. 2009 Jul;19 Suppl 1:i96-106
pubmed: 19386638
Light Sci Appl. 2017 May 05;6(5):e16231
pubmed: 30167247
Neuroscience. 2003;116(1):223-35
pubmed: 12535955
Physiol Behav. 2017 Sep 1;178:43-65
pubmed: 27871862
Neuropsychopharmacology. 2016 Jul;41(8):2133-46
pubmed: 26797244
Neuron. 2015 Sep 2;87(5):946-61
pubmed: 26335642
Nat Neurosci. 2015 Nov;18(11):1641-7
pubmed: 26457552
Nature. 2005 Oct 27;437(7063):1279-85
pubmed: 16251953
Brain. 1993 Aug;116 ( Pt 4):795-809
pubmed: 8353709
Psychopharmacology (Berl). 2020 Aug;237(8):2517-2530
pubmed: 32445053
Curr Biol. 2021 May 10;31(9):1893-1902.e5
pubmed: 33705720
Nature. 2007 Nov 15;450(7168):420-4
pubmed: 17943086
Neurobiol Aging. 1991 Sep-Oct;12(5):511-6
pubmed: 1770986
Science. 2017 Sep 29;357(6358):1406-1411
pubmed: 28963257
Cell. 1999 Aug 20;98(4):437-51
pubmed: 10481909
Nature. 1986 Jan 23-29;319(6051):326-9
pubmed: 3001538
J Comp Neurol. 2015 Apr 15;523(6):907-20
pubmed: 25424719
Neurology. 1994 Jan;44(1):84-9
pubmed: 7904735
Nat Commun. 2015 Nov 03;6:8744
pubmed: 26524973
Neuron. 2019 May 8;102(3):653-667.e6
pubmed: 30879785
J Neurosci. 2013 May 1;33(18):7627-40
pubmed: 23637157
Science. 1996 Jan 12;271(5246):216-9
pubmed: 8539624
J Comp Neurol. 2011 Apr 1;519(5):933-56
pubmed: 21280045
Nature. 2020 May;581(7807):204-208
pubmed: 32405000
Nat Commun. 2016 Jun 16;7:11937
pubmed: 27306314
Am J Alzheimers Dis Other Demen. 2015 Aug;30(5):478-87
pubmed: 25380804