Galacto-Oligosaccharide Supplementation Modulates Pathogen-Commensal Competition between Streptococcus agalactiae and Streptococcus salivarius.
Journal
Chembiochem : a European journal of chemical biology
ISSN: 1439-7633
Titre abrégé: Chembiochem
Pays: Germany
ID NLM: 100937360
Informations de publication
Date de publication:
04 02 2022
04 02 2022
Historique:
revised:
16
11
2021
received:
15
10
2021
pubmed:
18
11
2021
medline:
9
3
2022
entrez:
17
11
2021
Statut:
ppublish
Résumé
The members of the infant microbiome are governed by feeding method (breastmilk vs. formula). Regardless of the source of nutrition, a competitive growth advantage can be provided to commensals through prebiotics - either human milk oligosaccharides (HMOs) or plant oligosaccharides that are supplemented into formula. To characterize how prebiotics modulate commensal - pathogen interactions, we have designed and studied a minimal microbiome where a pathogen, Streptococcus agalactiae engages with a commensal, Streptococcus salivarius. We discovered that while S. agalactiae suppresses the growth of S. salivarius via increased lactic acid production, galacto-oligosaccharides (GOS) supplementation reverses the effect. This result has major implications in characterizing how single species survive in the gut, what niche they occupy, and how they engage with other community members.
Identifiants
pubmed: 34788501
doi: 10.1002/cbic.202100559
pmc: PMC9197176
mid: NIHMS1784512
doi:
Substances chimiques
Oligosaccharides
0
Prebiotics
0
Lactic Acid
33X04XA5AT
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
e202100559Subventions
Organisme : BLRD VA
ID : I01 BX005352
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD090061
Pays : United States
Organisme : National Science Foundation
ID : 1847804
Organisme : College of Arts & Science at Vanderbilt University
Informations de copyright
© 2021 Wiley-VCH GmbH.
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