Mitigating Fugitive Aerosols During Aerosol Delivery via High-Flow Nasal Cannula Devices.
COVID-19
aerosol generating procedure
high-flow nasal cannula
mitigation
nebulization
Journal
Respiratory care
ISSN: 1943-3654
Titre abrégé: Respir Care
Pays: United States
ID NLM: 7510357
Informations de publication
Date de publication:
04 2022
04 2022
Historique:
pubmed:
19
11
2021
medline:
1
4
2022
entrez:
18
11
2021
Statut:
ppublish
Résumé
Aerosol delivery via high-flow nasal cannula (HFNC) has attracted clinical interest in recent years. However, both HFNC and nebulization are categorized as aerosol-generating procedures (AGPs). In vitro studies raised concerns that AGPs had high transmission risk. Very few in vivo studies examined fugitive aerosols with nebulization via HFNC, and effective methods to mitigate aerosol dispersion are unknown. Two HFNC devices (Airvo 2 and Vapotherm) with or without a vibrating mesh nebulizer were compared; HFNC alone, surgical mask over HFNC interface, and HFNC with face tent scavenger were used in a random order for 9 healthy volunteers. Fugitive aerosol concentrations at sizes of 0.3-10.0 μm were continuously measured by particle sizers placed at 1 and 3 ft from participants. On a different day, 6 of the 9 participants received 6 additional nebulizer treatments via vibrating mesh nebulizer or small-volume nebulizer (SVN) with a face mask or a mouthpiece with/without an expiratory filter. In vitro simulation was employed to quantify inhaled dose of albuterol with vibrating mesh nebulizer via Airvo 2 and Vapotherm. Compared to baseline, neither HFNC device generated higher aerosol concentrations. Compared to HFNC alone, vibrating mesh nebulizer via Airvo 2 generated higher 0.3-1.0 μm particles (all During aerosol delivery via HFNC, Airvo 2 generated higher inhaled dose and consequently higher fugitive aerosols than Vapotherm. Simple measures, such as placing a surgical mask over nasal cannula during nebulization via HFNC, could effectively reduce fugitive aerosol concentrations.
Sections du résumé
BACKGROUND
Aerosol delivery via high-flow nasal cannula (HFNC) has attracted clinical interest in recent years. However, both HFNC and nebulization are categorized as aerosol-generating procedures (AGPs). In vitro studies raised concerns that AGPs had high transmission risk. Very few in vivo studies examined fugitive aerosols with nebulization via HFNC, and effective methods to mitigate aerosol dispersion are unknown.
METHODS
Two HFNC devices (Airvo 2 and Vapotherm) with or without a vibrating mesh nebulizer were compared; HFNC alone, surgical mask over HFNC interface, and HFNC with face tent scavenger were used in a random order for 9 healthy volunteers. Fugitive aerosol concentrations at sizes of 0.3-10.0 μm were continuously measured by particle sizers placed at 1 and 3 ft from participants. On a different day, 6 of the 9 participants received 6 additional nebulizer treatments via vibrating mesh nebulizer or small-volume nebulizer (SVN) with a face mask or a mouthpiece with/without an expiratory filter. In vitro simulation was employed to quantify inhaled dose of albuterol with vibrating mesh nebulizer via Airvo 2 and Vapotherm.
RESULTS
Compared to baseline, neither HFNC device generated higher aerosol concentrations. Compared to HFNC alone, vibrating mesh nebulizer via Airvo 2 generated higher 0.3-1.0 μm particles (all
CONCLUSIONS
During aerosol delivery via HFNC, Airvo 2 generated higher inhaled dose and consequently higher fugitive aerosols than Vapotherm. Simple measures, such as placing a surgical mask over nasal cannula during nebulization via HFNC, could effectively reduce fugitive aerosol concentrations.
Identifiants
pubmed: 34789564
pii: respcare.09589
doi: 10.4187/respcare.09589
doi:
Substances chimiques
Aerosols
0
Bronchodilator Agents
0
Albuterol
QF8SVZ843E
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
404-414Informations de copyright
Copyright © 2022 by Daedalus Enterprises.
Déclaration de conflit d'intérêts
Dr Li discloses relationships with Fisher & Paykel Healthcare, Aerogen, The Rice Foundation, the American Associate for Respiratory Care, and Heyer. Dr Li also serves as Section Editor for Respiratory Care. Dr Fink is Chief Science Officer for Aerogen Pharma Corp. Dr Dhand discloses relationships with GSK Pharmaceuticals, Boehringer Ingelheim, Mylan, Teva, and AstraZeneca Pharmaceuticals. The other authors have disclosed no conflicts of interest.