Instrumental variable analysis using offspring BMI in childhood as an indicator of parental BMI in relation to mortality.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
17 11 2021
17 11 2021
Historique:
received:
25
05
2021
accepted:
19
10
2021
entrez:
18
11
2021
pubmed:
19
11
2021
medline:
1
2
2022
Statut:
epublish
Résumé
Childhood BMI shows associations with adult mortality, but these may be influenced by effects of ill health in childhood on BMI and later mortality. To avoid this, we used offspring childhood BMI as an instrumental variable (IV) for own BMI in relation to mortality and compared it with conventional associations of own childhood BMI and own mortality. We included 36,097 parent-offspring pairs with measured heights and weights from the Copenhagen School Health Records Register and register-based information on death. Hazard ratios (HR) were estimated using adjusted Cox regression models. For all-cause mortality, per zBMI at age 7 the conventional HR = 1.07 (95%CI: 1.04-1.09) in women and 1.02 (95%CI: 0.92-1.14) in men, whereas the IV HR = 1.23 (95%CI: 1.15-1.32) in women and 1.05 (95%CI: 0.94-1.17) in men. Per zBMI at age 13, the conventional HR = 1.11 (95%CI: 1.08-1.15) in women and 1.03 (95%CI: 0.99-1.06) in men, whereas the IV HR = 1.30 (95%CI: 1.19-1.42) in women and 1.15 (95%CI: 1.04-1.29) in men. Only conventional models showed indications of J-shaped associations. Our IV analyses suggest that there is a causal relationship between BMI and mortality that is positive at both high and low BMI values.
Identifiants
pubmed: 34789785
doi: 10.1038/s41598-021-01352-w
pii: 10.1038/s41598-021-01352-w
pmc: PMC8599489
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
22408Subventions
Organisme : Medical Research Council
ID : MC_UU_00011/1
Pays : United Kingdom
Organisme : The Novo Nordisk Foundation
ID : NNF17OC0028338
Informations de copyright
© 2021. The Author(s).
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