Beneficial Effect of Saharan Propolis on Glucose Metabolism in Streptozotocin- induced Diabetic Rats.
Propolis
antidiabetic
antioxidant activity
medicinal plant.
phytochimestry
streptozotocin
Journal
Cardiovascular & hematological disorders drug targets
ISSN: 2212-4063
Titre abrégé: Cardiovasc Hematol Disord Drug Targets
Pays: United Arab Emirates
ID NLM: 101269160
Informations de publication
Date de publication:
2021
2021
Historique:
received:
31
01
2021
revised:
28
07
2021
accepted:
10
08
2021
pubmed:
19
11
2021
medline:
2
2
2022
entrez:
18
11
2021
Statut:
ppublish
Résumé
The aim of the study was to evaluate the antihyperglycemic activity of propolis from Saharan region of Morocco. Propolis is known from ancient times for its beneficial action on health. The study aimed to evaluate the effect of Moroccan propolis aqueous extract from the desert region on glycemia and lipid metabolism. The antihyperglycemic and antidyslipidemic activities of Moroccan propolis aqueous extract were evaluated in streptozotocin-induced diabetic rats. Glycemia was monitored during acute (6h) and subchronic treatments. Histopathological analysis of the liver and the serum lipid profile was also evaluated in addition to the glucose tolerance. This work demonstrated that the aqueous extract of Moroccan propolis exhibited a significant antihyperglycemic effect in diabetic rats. Histopathological data demonstrated that propolis acts positively on the liver of diabetic rats. In addition, the preliminary phytochemical screening revealed that Moroccan propolis contains several phytochemicals. Finally, Moroccan propolis had a potent antioxidant activity which may be due to the richness in polyphenols content (90.91 mg EAG/1 g of extract). The present study shows that Moroccan propolis from the hot desert region possesses a potent antihyperglycemic effect.
Sections du résumé
AIMS
The aim of the study was to evaluate the antihyperglycemic activity of propolis from Saharan region of Morocco.
BACKGROUND
Propolis is known from ancient times for its beneficial action on health.
OBJECTIVE
The study aimed to evaluate the effect of Moroccan propolis aqueous extract from the desert region on glycemia and lipid metabolism.
METHODS
The antihyperglycemic and antidyslipidemic activities of Moroccan propolis aqueous extract were evaluated in streptozotocin-induced diabetic rats. Glycemia was monitored during acute (6h) and subchronic treatments. Histopathological analysis of the liver and the serum lipid profile was also evaluated in addition to the glucose tolerance.
RESULTS
This work demonstrated that the aqueous extract of Moroccan propolis exhibited a significant antihyperglycemic effect in diabetic rats. Histopathological data demonstrated that propolis acts positively on the liver of diabetic rats. In addition, the preliminary phytochemical screening revealed that Moroccan propolis contains several phytochemicals. Finally, Moroccan propolis had a potent antioxidant activity which may be due to the richness in polyphenols content (90.91 mg EAG/1 g of extract).
CONCLUSION
The present study shows that Moroccan propolis from the hot desert region possesses a potent antihyperglycemic effect.
Identifiants
pubmed: 34792007
pii: CHDDT-EPUB-118935
doi: 10.2174/1871529X21666211118141935
doi:
Substances chimiques
Blood Glucose
0
Hypoglycemic Agents
0
Plant Extracts
0
Streptozocin
5W494URQ81
Propolis
9009-62-5
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
243-252Subventions
Organisme : CNRST
ID : PPR/2015/35
Informations de copyright
Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.